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An unusual enterovirus outbreak in Denmark : clinical characteristics and molecular epidemiology

Vestergaard, Hanne T; Johnsen, Christina K and Böttiger, Blenda LU (2004) In Scandinavian Journal of Infectious Diseases 36(11-12). p.7-840
Abstract

In 2000, a large enterovirus (EV) outbreak was seen in Denmark; the number of patients with a verified EV infection was 3-fold higher compared to previous y. Echovirus 30 (E30) was the dominant EV type and was detected in 31% of all 306 EV positive patients and in 61% of the 155 patients in whom typing was successful. The outbreak started in February and peaked in June, which is unusually early in a temperate climate and not registered before in Denmark. The age distribution of the patients also differed from previous y with a significantly higher proportion of older children and adults being affected. The patients had mainly symptoms consistent with aseptic meningitis. A phylogenetic analysis based upon a part of the VP1 structural... (More)

In 2000, a large enterovirus (EV) outbreak was seen in Denmark; the number of patients with a verified EV infection was 3-fold higher compared to previous y. Echovirus 30 (E30) was the dominant EV type and was detected in 31% of all 306 EV positive patients and in 61% of the 155 patients in whom typing was successful. The outbreak started in February and peaked in June, which is unusually early in a temperate climate and not registered before in Denmark. The age distribution of the patients also differed from previous y with a significantly higher proportion of older children and adults being affected. The patients had mainly symptoms consistent with aseptic meningitis. A phylogenetic analysis based upon a part of the VP1 structural gene of 21 E30 isolates showed that the Danish isolates belonged to the E30 genotype which has prevailed in Europe during the last few years. However, they constituted a separated cluster compared with 2 other outbreaks in other parts of Europe in 2000.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adolescent, Adult, Age Distribution, Child, Child, Preschool, Denmark/epidemiology, Disease Outbreaks, Enterovirus/genetics, Enterovirus Infections/epidemiology, Female, Humans, Infant, Infant, Newborn, Male, Meningitis, Aseptic/epidemiology, Molecular Epidemiology, Phylogeny, Seasons
in
Scandinavian Journal of Infectious Diseases
volume
36
issue
11-12
pages
7 - 840
publisher
Informa Healthcare
external identifiers
  • scopus:11344287218
ISSN
0036-5548
DOI
10.1080/00365540410021153
language
English
LU publication?
no
id
d49e9dfe-9c59-4b77-8704-3c82129f31b8
date added to LUP
2019-05-02 14:26:38
date last changed
2019-05-06 16:01:48
@article{d49e9dfe-9c59-4b77-8704-3c82129f31b8,
  abstract     = {<p>In 2000, a large enterovirus (EV) outbreak was seen in Denmark; the number of patients with a verified EV infection was 3-fold higher compared to previous y. Echovirus 30 (E30) was the dominant EV type and was detected in 31% of all 306 EV positive patients and in 61% of the 155 patients in whom typing was successful. The outbreak started in February and peaked in June, which is unusually early in a temperate climate and not registered before in Denmark. The age distribution of the patients also differed from previous y with a significantly higher proportion of older children and adults being affected. The patients had mainly symptoms consistent with aseptic meningitis. A phylogenetic analysis based upon a part of the VP1 structural gene of 21 E30 isolates showed that the Danish isolates belonged to the E30 genotype which has prevailed in Europe during the last few years. However, they constituted a separated cluster compared with 2 other outbreaks in other parts of Europe in 2000.</p>},
  author       = {Vestergaard, Hanne T and Johnsen, Christina K and Böttiger, Blenda},
  issn         = {0036-5548},
  keyword      = {Adolescent,Adult,Age Distribution,Child,Child, Preschool,Denmark/epidemiology,Disease Outbreaks,Enterovirus/genetics,Enterovirus Infections/epidemiology,Female,Humans,Infant,Infant, Newborn,Male,Meningitis, Aseptic/epidemiology,Molecular Epidemiology,Phylogeny,Seasons},
  language     = {eng},
  number       = {11-12},
  pages        = {7--840},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {An unusual enterovirus outbreak in Denmark : clinical characteristics and molecular epidemiology},
  url          = {http://dx.doi.org/10.1080/00365540410021153},
  volume       = {36},
  year         = {2004},
}