A Systems View of the Heparan Sulfate Interactome
Gómez Toledo, Alejandro LU ; Sorrentino, James T ; Sandoval, Daniel R ; Malmström, Johan LU
; Lewis, Nathan E
and Esko, Jeffrey D
(2021)
In The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
69(2).
p.105-119
- Abstract
Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate-binding proteins, including extracellular matrix proteins, growth factors and morphogens, cytokines and chemokines, apolipoproteins and lipases, adhesion and growth factor receptors, and components of the complement and coagulation system. This review highlights recent progress in the characterization of the so-called "heparan sulfate interactome," with a major focus on systems-wide strategies as... (More)
Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate-binding proteins, including extracellular matrix proteins, growth factors and morphogens, cytokines and chemokines, apolipoproteins and lipases, adhesion and growth factor receptors, and components of the complement and coagulation system. This review highlights recent progress in the characterization of the so-called "heparan sulfate interactome," with a major focus on systems-wide strategies as a tool for discovery and characterization of this subproteome. In addition, we compiled all heparan sulfate-binding proteins reported in the literature to date and grouped them into a few major functional classes by applying a networking approach.
(Less)
- author
- Gómez Toledo, Alejandro
LU
; Sorrentino, James T
; Sandoval, Daniel R
; Malmström, Johan
LU
; Lewis, Nathan E
and Esko, Jeffrey D
- organization
- publishing date
- 2021-02
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
- volume
- 69
- issue
- 2
- pages
- 105 - 119
- publisher
- Histochemical Society
- external identifiers
-
- pmid:33494649
- scopus:85099809486
- ISSN
- 0022-1554
- DOI
- 10.1369/0022155420988661
- language
- English
- LU publication?
- yes
- id
- d49f1227-b2ad-4659-bc74-48e926fea3f6
- date added to LUP
- 2021-01-31 23:14:11
- date last changed
- 2024-06-13 06:21:19
@article{d49f1227-b2ad-4659-bc74-48e926fea3f6,
abstract = {{<p>Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate-binding proteins, including extracellular matrix proteins, growth factors and morphogens, cytokines and chemokines, apolipoproteins and lipases, adhesion and growth factor receptors, and components of the complement and coagulation system. This review highlights recent progress in the characterization of the so-called "heparan sulfate interactome," with a major focus on systems-wide strategies as a tool for discovery and characterization of this subproteome. In addition, we compiled all heparan sulfate-binding proteins reported in the literature to date and grouped them into a few major functional classes by applying a networking approach.</p>}},
author = {{Gómez Toledo, Alejandro and Sorrentino, James T and Sandoval, Daniel R and Malmström, Johan and Lewis, Nathan E and Esko, Jeffrey D}},
issn = {{0022-1554}},
language = {{eng}},
number = {{2}},
pages = {{105--119}},
publisher = {{Histochemical Society}},
series = {{The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society}},
title = {{A Systems View of the Heparan Sulfate Interactome}},
url = {{http://dx.doi.org/10.1369/0022155420988661}},
doi = {{10.1369/0022155420988661}},
volume = {{69}},
year = {{2021}},
}