Membrane applications for bulk fermentation processes: From antibiotics to biochemicals
Lipnizki, Frank LU
(2016)
Membranes in bioprocessing
- Abstract
- 1. Introduction
The third wave of biotechnology – white biotechnology – started with the end of the 20th century with the goal to replace conventional chemical processes based on C2/C3 chemistry by biotechnological processes. In biotechnology fermentation is used as standard conversion process for the production of bulk fermentation products such as antibiotics, enzymes, bioethanol and organic acids. Since the 1970ies cross-flow membrane processes have established themselves in the downstream processing of fermentation processes for the recovery and purification of fermentation products. The first part of presentation will provide an overview on the current status of membrane processes in the bulk fermentation industry focusing on the... (More) - 1. Introduction
The third wave of biotechnology – white biotechnology – started with the end of the 20th century with the goal to replace conventional chemical processes based on C2/C3 chemistry by biotechnological processes. In biotechnology fermentation is used as standard conversion process for the production of bulk fermentation products such as antibiotics, enzymes, bioethanol and organic acids. Since the 1970ies cross-flow membrane processes have established themselves in the downstream processing of fermentation processes for the recovery and purification of fermentation products. The first part of presentation will provide an overview on the current status of membrane processes in the bulk fermentation industry focusing on the established applications such as antibiotics, enzymes and organic acids, while the second part of the presentation will focus on biorefineries.
2. Current status
In the production of bulk fermentation products such as antibiotics, enzymes and organic acids cross-flow membrane processes are widely established. Starting at the front-end of the production, the combination of microfiltration/ultrafiltration with diafiltration can be used for separation of the active ingredients from the fermentation broth. Later in the downstream processing ultrafiltration, nanofiltration, and reverse osmosis are used for concentration and purification of the active ingredients. Furthermore, membrane processes can be in the water loop of fermentation plants to prepare in-take water to match the required purities and in the treatment of wastewater, e.g. evaporator condensate by reverse osmosis or end-of-pipe by membrane bioreactors.
3. Biorefineries
The concept of biorefineries aims on full utilization of the feedstock for the simultaneous production of e.g. food, biofuels and biochemicals. Raw materials are mainly sugars and starch but to avoid any competition with the food chain, the focus is moving towards alternative sources of raw materials, e.g. lignocellulosic biomass. In concept of biorefineries membranes can play a significant role as highly selective and low-energy separation processes. The production steps in particular at the front-end of a biorefinery vary with the raw material. If e.g. lignocellulosic biomass is used often a pre-treatment is required while using starch a saccarification step converting the starch to sugars might be necessary. In these initial steps in particular microfiltration/ultrafiltration can be used for the polishing of the substrate before fermentation, while reverse osmosis can be used for the concentration of the substrate. During the fermentation step, the biofuels/biochemicals are produced and continuously removed by membrane processes such as microfiltration and ultrafiltration to prevent product inhibitions stopping the fermentation process. In analogy to the conventional fermentation industry membrane processes like microfiltration, ultrafiltration, nanofiltration and reverse osmosis can be used in the downstream processes after fermentation for concentration and polishing of the biochemicals.
4. Outlook
Overall, this presentation will demonstrate that cross-flow membrane processes have established themselves in the bulk fermentation industry and further have a great potential in future biorefineries.
(Less)
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https://lup.lub.lu.se/record/d4b6b777-7279-4b04-b004-4928c7694992
- author
- Lipnizki, Frank
LU
- organization
- publishing date
- 2016
- type
- Contribution to conference
- publication status
- published
- subject
- keywords
- Membranes, Biotech industry
- conference name
- Membranes in bioprocessing
- conference location
- Bologna, Italy
- conference dates
- 2016-05-08 - 2016-05-10
- language
- English
- LU publication?
- yes
- id
- d4b6b777-7279-4b04-b004-4928c7694992
- date added to LUP
- 2018-10-05 13:11:59
- date last changed
- 2019-03-08 02:29:44
@misc{d4b6b777-7279-4b04-b004-4928c7694992,
abstract = {{1. Introduction<br/>The third wave of biotechnology – white biotechnology – started with the end of the 20th century with the goal to replace conventional chemical processes based on C2/C3 chemistry by biotechnological processes. In biotechnology fermentation is used as standard conversion process for the production of bulk fermentation products such as antibiotics, enzymes, bioethanol and organic acids. Since the 1970ies cross-flow membrane processes have established themselves in the downstream processing of fermentation processes for the recovery and purification of fermentation products. The first part of presentation will provide an overview on the current status of membrane processes in the bulk fermentation industry focusing on the established applications such as antibiotics, enzymes and organic acids, while the second part of the presentation will focus on biorefineries. <br/><br/>2. Current status<br/>In the production of bulk fermentation products such as antibiotics, enzymes and organic acids cross-flow membrane processes are widely established. Starting at the front-end of the production, the combination of microfiltration/ultrafiltration with diafiltration can be used for separation of the active ingredients from the fermentation broth. Later in the downstream processing ultrafiltration, nanofiltration, and reverse osmosis are used for concentration and purification of the active ingredients. Furthermore, membrane processes can be in the water loop of fermentation plants to prepare in-take water to match the required purities and in the treatment of wastewater, e.g. evaporator condensate by reverse osmosis or end-of-pipe by membrane bioreactors. <br/><br/><br/><br/>3. Biorefineries<br/>The concept of biorefineries aims on full utilization of the feedstock for the simultaneous production of e.g. food, biofuels and biochemicals. Raw materials are mainly sugars and starch but to avoid any competition with the food chain, the focus is moving towards alternative sources of raw materials, e.g. lignocellulosic biomass. In concept of biorefineries membranes can play a significant role as highly selective and low-energy separation processes. The production steps in particular at the front-end of a biorefinery vary with the raw material. If e.g. lignocellulosic biomass is used often a pre-treatment is required while using starch a saccarification step converting the starch to sugars might be necessary. In these initial steps in particular microfiltration/ultrafiltration can be used for the polishing of the substrate before fermentation, while reverse osmosis can be used for the concentration of the substrate. During the fermentation step, the biofuels/biochemicals are produced and continuously removed by membrane processes such as microfiltration and ultrafiltration to prevent product inhibitions stopping the fermentation process. In analogy to the conventional fermentation industry membrane processes like microfiltration, ultrafiltration, nanofiltration and reverse osmosis can be used in the downstream processes after fermentation for concentration and polishing of the biochemicals. <br/><br/>4. Outlook<br/>Overall, this presentation will demonstrate that cross-flow membrane processes have established themselves in the bulk fermentation industry and further have a great potential in future biorefineries. <br/>}},
author = {{Lipnizki, Frank}},
keywords = {{Membranes; Biotech industry}},
language = {{eng}},
title = {{Membrane applications for bulk fermentation processes: From antibiotics to biochemicals}},
year = {{2016}},
}