Functional role of central muscarinic receptors for micturition in normal conscious rats
(2002) In Journal of Urology 168(5). p.2258-2262- Abstract
- Purpose: Antimuscarinic agents, which are used in to treat urgency and urge incontinence, have well-known effects on peripheral muscarinic receptors. However, some currently used drugs may have effects on muscarinic receptors in the brain and/or spinal cord involved in voiding control. We tested if muscarinic receptors within the central nervous system mediate a tonic excitatory influence on voiding in rats and if these receptors can be differently influenced by antimuscarinic drugs. Materials and Methods: The effects on cystometrography of intracerebroventricular atropine, oxybutynin, tolterodine and darifenacin were investigated in normal conscious rats. Results: Atropine (0.2 to 2 nmol.) dose dependently affected urodynamic parameters.... (More)
- Purpose: Antimuscarinic agents, which are used in to treat urgency and urge incontinence, have well-known effects on peripheral muscarinic receptors. However, some currently used drugs may have effects on muscarinic receptors in the brain and/or spinal cord involved in voiding control. We tested if muscarinic receptors within the central nervous system mediate a tonic excitatory influence on voiding in rats and if these receptors can be differently influenced by antimuscarinic drugs. Materials and Methods: The effects on cystometrography of intracerebroventricular atropine, oxybutynin, tolterodine and darifenacin were investigated in normal conscious rats. Results: Atropine (0.2 to 2 nmol.) dose dependently affected urodynamic parameters. At 2 nmol. in 6 rats the drug decreased voiding pressure (p <0.01), and increased bladder capacity (p <0.001), voided volume (p <0.05) and post-void residual volume (p <0.05). In 6 rats oxybutynin (6 to 40 nmol.) given at a dose of 6 nmol. caused no change in cystometric parameters, while at 20 nmol. the drug decreased voiding pressure (p <0.01). Tolterodine (2 to 20 nmol.) dose dependently changed urodynamic parameters, while at 20 nmol. in 6 rats the drug decreased voiding pressure (p <0.01) and increased bladder capacity (p <0.05) and voided volume (p <0.05). Darifenacin given at a dose of 20 nmol. in 6 rats caused no change in cystometric parameters. Conclusions: Muscarinic receptor mechanisms in the central nervous system mediate a tonic excitatory influence on voiding in rats, while nonsubtype selective antimuscarinic drugs may have an inhibitory effect on these mechanisms. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/325562
- author
- Ishizuka, O ; Gu, BJ ; Yang, ZX ; Nishizawa, O and Andersson, Kenneth LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- central nervous, Sprague-Dawley, rats, muscarinic, urination, receptors, system
- in
- Journal of Urology
- volume
- 168
- issue
- 5
- pages
- 2258 - 2262
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000178562100127
- pmid:12394771
- scopus:0036837459
- ISSN
- 1527-3792
- DOI
- 10.1016/S0022-5347(05)64367-4
- language
- English
- LU publication?
- yes
- id
- d4caacac-36cc-43a4-82c4-5be92dc86bfd (old id 325562)
- date added to LUP
- 2016-04-01 16:57:20
- date last changed
- 2022-01-28 23:17:33
@article{d4caacac-36cc-43a4-82c4-5be92dc86bfd,
abstract = {{Purpose: Antimuscarinic agents, which are used in to treat urgency and urge incontinence, have well-known effects on peripheral muscarinic receptors. However, some currently used drugs may have effects on muscarinic receptors in the brain and/or spinal cord involved in voiding control. We tested if muscarinic receptors within the central nervous system mediate a tonic excitatory influence on voiding in rats and if these receptors can be differently influenced by antimuscarinic drugs. Materials and Methods: The effects on cystometrography of intracerebroventricular atropine, oxybutynin, tolterodine and darifenacin were investigated in normal conscious rats. Results: Atropine (0.2 to 2 nmol.) dose dependently affected urodynamic parameters. At 2 nmol. in 6 rats the drug decreased voiding pressure (p <0.01), and increased bladder capacity (p <0.001), voided volume (p <0.05) and post-void residual volume (p <0.05). In 6 rats oxybutynin (6 to 40 nmol.) given at a dose of 6 nmol. caused no change in cystometric parameters, while at 20 nmol. the drug decreased voiding pressure (p <0.01). Tolterodine (2 to 20 nmol.) dose dependently changed urodynamic parameters, while at 20 nmol. in 6 rats the drug decreased voiding pressure (p <0.01) and increased bladder capacity (p <0.05) and voided volume (p <0.05). Darifenacin given at a dose of 20 nmol. in 6 rats caused no change in cystometric parameters. Conclusions: Muscarinic receptor mechanisms in the central nervous system mediate a tonic excitatory influence on voiding in rats, while nonsubtype selective antimuscarinic drugs may have an inhibitory effect on these mechanisms.}},
author = {{Ishizuka, O and Gu, BJ and Yang, ZX and Nishizawa, O and Andersson, Kenneth}},
issn = {{1527-3792}},
keywords = {{central nervous; Sprague-Dawley; rats; muscarinic; urination; receptors; system}},
language = {{eng}},
number = {{5}},
pages = {{2258--2262}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Urology}},
title = {{Functional role of central muscarinic receptors for micturition in normal conscious rats}},
url = {{http://dx.doi.org/10.1016/S0022-5347(05)64367-4}},
doi = {{10.1016/S0022-5347(05)64367-4}},
volume = {{168}},
year = {{2002}},
}