Mammographic calcifications undergoing percutaneous biopsy : outcome in women with and without a personal history of breast cancer
(2023) In Radiologia Medica 128(2). p.149-159- Abstract
Purpose: To compare the positive predictive values (PPVs) of BI-RADS categories used to assess pure mammographic calcifications in women with and without a previous history of breast cancer (PHBC). Materials and methods: In this retrospective study, all consecutive pure mammographic calcifications (n = 320) undergoing a stereotactic biopsy between 2016 and 2018 were identified. Mammograms were evaluated in consensus by two radiologists according to BI-RADS and blinded to patient history and pathology results. Final pathologic results were used as the standard of reference. PPV of BI-RADS categories were compared between the two groups. Data were evaluated using standard statistics, Mann–Whitney U tests and Chi-square tests. Results: Two... (More)
Purpose: To compare the positive predictive values (PPVs) of BI-RADS categories used to assess pure mammographic calcifications in women with and without a previous history of breast cancer (PHBC). Materials and methods: In this retrospective study, all consecutive pure mammographic calcifications (n = 320) undergoing a stereotactic biopsy between 2016 and 2018 were identified. Mammograms were evaluated in consensus by two radiologists according to BI-RADS and blinded to patient history and pathology results. Final pathologic results were used as the standard of reference. PPV of BI-RADS categories were compared between the two groups. Data were evaluated using standard statistics, Mann–Whitney U tests and Chi-square tests. Results: Two hundred sixty-eight patients (274 lesions, median age 54 years, inter-quartile range, 50–65 years) with a PHBC (n = 46) and without a PHBC (n = 222) were included. Overall PPVs were the following: BI-RADS 2, 0% (0 of 56); BI-RADS 3, 9.1% (1 of 11); BI-RADS 4a, 16.2% (6 of 37); BI-RADS 4b, 37.5% (48 of 128); BI-RADS 4c, 47.3% (18 of 38) and BI-RADS 5, 100% (4 of 4). The PPV of BI-RADS categories was similar in patients with and without a PHBC (P =.715). Calcifications were more often malignant in patients with a PHBC older than 10 years (47.3%, 9 of 19) compared to 1–2 years (25%, 1 of 4), 2–5 years (20%, 2 of 10) and 5–10 years (0%, of 13) from the first breast cancer (P =.005). Conclusion: PPV of mammographic calcifications is similar in women with or without PHBC when BI-RADS classification is strictly applied. A higher risk of malignancy was observed in patients with a PHBC longer than 10 years.
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- author
- Bertani, Valeria ; Berger, Nicole ; Eberhard, Matthias ; Lång, Kristina LU ; Urbani, Martina ; La Grassa, Manuela ; Balestreri, Luca ; Boss, Andreas ; Frauenfelder, Thomas and Marcon, Magda
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Breast cancer, Digital mammography, Microcalcifications
- in
- Radiologia Medica
- volume
- 128
- issue
- 2
- pages
- 11 pages
- publisher
- Edizioni Minerva Medica
- external identifiers
-
- pmid:36598734
- scopus:85145598874
- ISSN
- 0033-8362
- DOI
- 10.1007/s11547-022-01583-5
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2023, The Author(s).
- id
- d4eeb2b6-f7df-4ca5-8765-8309387535a3
- date added to LUP
- 2023-01-19 07:40:39
- date last changed
- 2024-07-12 01:45:18
@article{d4eeb2b6-f7df-4ca5-8765-8309387535a3,
abstract = {{<p>Purpose: To compare the positive predictive values (PPVs) of BI-RADS categories used to assess pure mammographic calcifications in women with and without a previous history of breast cancer (PHBC). Materials and methods: In this retrospective study, all consecutive pure mammographic calcifications (n = 320) undergoing a stereotactic biopsy between 2016 and 2018 were identified. Mammograms were evaluated in consensus by two radiologists according to BI-RADS and blinded to patient history and pathology results. Final pathologic results were used as the standard of reference. PPV of BI-RADS categories were compared between the two groups. Data were evaluated using standard statistics, Mann–Whitney U tests and Chi-square tests. Results: Two hundred sixty-eight patients (274 lesions, median age 54 years, inter-quartile range, 50–65 years) with a PHBC (n = 46) and without a PHBC (n = 222) were included. Overall PPVs were the following: BI-RADS 2, 0% (0 of 56); BI-RADS 3, 9.1% (1 of 11); BI-RADS 4a, 16.2% (6 of 37); BI-RADS 4b, 37.5% (48 of 128); BI-RADS 4c, 47.3% (18 of 38) and BI-RADS 5, 100% (4 of 4). The PPV of BI-RADS categories was similar in patients with and without a PHBC (P =.715). Calcifications were more often malignant in patients with a PHBC older than 10 years (47.3%, 9 of 19) compared to 1–2 years (25%, 1 of 4), 2–5 years (20%, 2 of 10) and 5–10 years (0%, of 13) from the first breast cancer (P =.005). Conclusion: PPV of mammographic calcifications is similar in women with or without PHBC when BI-RADS classification is strictly applied. A higher risk of malignancy was observed in patients with a PHBC longer than 10 years.</p>}},
author = {{Bertani, Valeria and Berger, Nicole and Eberhard, Matthias and Lång, Kristina and Urbani, Martina and La Grassa, Manuela and Balestreri, Luca and Boss, Andreas and Frauenfelder, Thomas and Marcon, Magda}},
issn = {{0033-8362}},
keywords = {{Breast cancer; Digital mammography; Microcalcifications}},
language = {{eng}},
number = {{2}},
pages = {{149--159}},
publisher = {{Edizioni Minerva Medica}},
series = {{Radiologia Medica}},
title = {{Mammographic calcifications undergoing percutaneous biopsy : outcome in women with and without a personal history of breast cancer}},
url = {{http://dx.doi.org/10.1007/s11547-022-01583-5}},
doi = {{10.1007/s11547-022-01583-5}},
volume = {{128}},
year = {{2023}},
}