Characterization of molecularly imprinted polymer nanoparticles by photon correlation spectroscopy
Malm, Bjoern ; Yoshimatsu, Keiichi LU ; Ye, Lei LU
and Krozer, Anatol
(2014)
In Journal of Molecular Recognition
27(12).
p.714-721
- Abstract
- We follow template-binding induced aggregation of nanoparticles enantioselectively imprinted against (S)-propranolol, and the non-imprinted ones, using photon correlation spectroscopy (dynamic light scattering). The method requires no separation steps. We have characterized binding of (R,S)-propranolol to the imprinted polymers and determined the degree of non-specificity by comparing the specific binding with the results obtained using non-imprinted nanoparticles. Using (S)-propranolol as a template for binding to (S)-imprinted nanoparticle, and (R)-propranolol as a non-specific control, we have determined range of concentrations where chiral recognition can be observed. By studying aggregation induced by three analytes related to... (More)
- We follow template-binding induced aggregation of nanoparticles enantioselectively imprinted against (S)-propranolol, and the non-imprinted ones, using photon correlation spectroscopy (dynamic light scattering). The method requires no separation steps. We have characterized binding of (R,S)-propranolol to the imprinted polymers and determined the degree of non-specificity by comparing the specific binding with the results obtained using non-imprinted nanoparticles. Using (S)-propranolol as a template for binding to (S)-imprinted nanoparticle, and (R)-propranolol as a non-specific control, we have determined range of concentrations where chiral recognition can be observed. By studying aggregation induced by three analytes related to propranolol, atenolol, betaxolol, and 1-amino-3-(naphthalen-1-yloxy)propan-2-ol, we were able to determine which parts of the template are involved in the specific binding, discuss several details of specific adsorption, and the structure of the imprinted site. Copyright (c) 2014 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4874895
- author
- Malm, Bjoern
; Yoshimatsu, Keiichi
LU
; Ye, Lei
LU
and Krozer, Anatol
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- molecularly imprinted polymers, Brownian motion, chiral selectivity, aggregation kinetics, colloidal suspension
- in
- Journal of Molecular Recognition
- volume
- 27
- issue
- 12
- pages
- 714 - 721
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000343997400004
- scopus:84927138481
- pmid:25319619
- ISSN
- 1099-1352
- DOI
- 10.1002/jmr.2397
- language
- English
- LU publication?
- yes
- id
- d517e5d9-d28c-4d2a-8197-4b16fc364963 (old id 4874895)
- date added to LUP
- 2016-04-01 10:38:48
- date last changed
- 2025-01-14 19:47:25
@article{d517e5d9-d28c-4d2a-8197-4b16fc364963,
abstract = {{We follow template-binding induced aggregation of nanoparticles enantioselectively imprinted against (S)-propranolol, and the non-imprinted ones, using photon correlation spectroscopy (dynamic light scattering). The method requires no separation steps. We have characterized binding of (R,S)-propranolol to the imprinted polymers and determined the degree of non-specificity by comparing the specific binding with the results obtained using non-imprinted nanoparticles. Using (S)-propranolol as a template for binding to (S)-imprinted nanoparticle, and (R)-propranolol as a non-specific control, we have determined range of concentrations where chiral recognition can be observed. By studying aggregation induced by three analytes related to propranolol, atenolol, betaxolol, and 1-amino-3-(naphthalen-1-yloxy)propan-2-ol, we were able to determine which parts of the template are involved in the specific binding, discuss several details of specific adsorption, and the structure of the imprinted site. Copyright (c) 2014 John Wiley & Sons, Ltd.}},
author = {{Malm, Bjoern and Yoshimatsu, Keiichi and Ye, Lei and Krozer, Anatol}},
issn = {{1099-1352}},
keywords = {{molecularly imprinted polymers; Brownian motion; chiral selectivity; aggregation kinetics; colloidal suspension}},
language = {{eng}},
number = {{12}},
pages = {{714--721}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Molecular Recognition}},
title = {{Characterization of molecularly imprinted polymer nanoparticles by photon correlation spectroscopy}},
url = {{http://dx.doi.org/10.1002/jmr.2397}},
doi = {{10.1002/jmr.2397}},
volume = {{27}},
year = {{2014}},
}