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Exposure to pesticides as risk factor for Non-Hodgkin's lymphoma and hairy cell leukemia : Pooled analysis of two Swedish case-control studies

Hardell, Lennart ; Eriksson, Mikael LU and Nordström, Marie (2002) In Leukemia and Lymphoma 43(5). p.1043-1049
Abstract

Increased risk for non-Hodgkin's lymphoma (NHL) following exposure to certain pesticides has previously been reported. To further elucidate the importance of phenoxyacetic acids and other pesticides in the etiology of NHL a pooled analysis was performed on two case-control studies, one on NHL and another on hairy cell leukemia (HCL), a rare subtype of NHL. The studies were population based with cases identified from cancer registry and controls from population registry. Data assessment was ascertained by questionnaires supplemented over the telephone by specially trained interviewers. The pooled analysis of NHL and HCL was based on 515 cases and 1141 controls. Increased risks in univariate analysis were found for subjects exposed to... (More)

Increased risk for non-Hodgkin's lymphoma (NHL) following exposure to certain pesticides has previously been reported. To further elucidate the importance of phenoxyacetic acids and other pesticides in the etiology of NHL a pooled analysis was performed on two case-control studies, one on NHL and another on hairy cell leukemia (HCL), a rare subtype of NHL. The studies were population based with cases identified from cancer registry and controls from population registry. Data assessment was ascertained by questionnaires supplemented over the telephone by specially trained interviewers. The pooled analysis of NHL and HCL was based on 515 cases and 1141 controls. Increased risks in univariate analysis were found for subjects exposed to herbicides (OR 1.75, CI 95% 1.26-2.42), insecticides (OR 1.43, CI95% 1.08-1.87), fungicides (OR 3.11, CI 95% 1.56-6.27) and impregnating agents (OR 1.48, CI 95% 1.11-1.96). Among herbicides, significant associations were found for glyphosate (OR 3.04, CI 95% 1.08-8.52) and 4-chloro-2-methyl phenoxyacetic acid (MCPA) (OR 2.62, CI 95% 1.40-4.88). For several categories of pesticides the highest risk was found for exposure during the latest decades before diagnosis. However, in multivariate analyses the only significantly increased risk was for a heterogeneous category of other herbicides than above.

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Contribution to journal
publication status
published
subject
keywords
Glyphosate, Hairy cell leukemia, Impregnating agents, Non-Hodgkin's lymphoma, Pesticides, Phenoxyacetic acids
in
Leukemia and Lymphoma
volume
43
issue
5
pages
1043 - 1049
publisher
Taylor & Francis
external identifiers
  • scopus:0036241213
  • pmid:12148884
ISSN
1042-8194
DOI
10.1080/10428190290021560
language
English
LU publication?
yes
id
d533a781-2563-46d0-92af-c9c1c438dcff
date added to LUP
2020-02-24 10:47:02
date last changed
2021-07-21 04:31:04
@article{d533a781-2563-46d0-92af-c9c1c438dcff,
  abstract     = {<p>Increased risk for non-Hodgkin's lymphoma (NHL) following exposure to certain pesticides has previously been reported. To further elucidate the importance of phenoxyacetic acids and other pesticides in the etiology of NHL a pooled analysis was performed on two case-control studies, one on NHL and another on hairy cell leukemia (HCL), a rare subtype of NHL. The studies were population based with cases identified from cancer registry and controls from population registry. Data assessment was ascertained by questionnaires supplemented over the telephone by specially trained interviewers. The pooled analysis of NHL and HCL was based on 515 cases and 1141 controls. Increased risks in univariate analysis were found for subjects exposed to herbicides (OR 1.75, CI 95% 1.26-2.42), insecticides (OR 1.43, CI95% 1.08-1.87), fungicides (OR 3.11, CI 95% 1.56-6.27) and impregnating agents (OR 1.48, CI 95% 1.11-1.96). Among herbicides, significant associations were found for glyphosate (OR 3.04, CI 95% 1.08-8.52) and 4-chloro-2-methyl phenoxyacetic acid (MCPA) (OR 2.62, CI 95% 1.40-4.88). For several categories of pesticides the highest risk was found for exposure during the latest decades before diagnosis. However, in multivariate analyses the only significantly increased risk was for a heterogeneous category of other herbicides than above.</p>},
  author       = {Hardell, Lennart and Eriksson, Mikael and Nordström, Marie},
  issn         = {1042-8194},
  language     = {eng},
  number       = {5},
  pages        = {1043--1049},
  publisher    = {Taylor & Francis},
  series       = {Leukemia and Lymphoma},
  title        = {Exposure to pesticides as risk factor for Non-Hodgkin's lymphoma and hairy cell leukemia : Pooled analysis of two Swedish case-control studies},
  url          = {http://dx.doi.org/10.1080/10428190290021560},
  doi          = {10.1080/10428190290021560},
  volume       = {43},
  year         = {2002},
}