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Kidney Transplantation in Childhood-Onset Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Long-Term Outcomes and Prognostic Factors

Trivioli, G. ; Mohammad, A.J. LU and Vaglio, Augusto (2026) In Clinical Journal of the American Society of Nephrology 21(3). p.480-493
Abstract
Background: – Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is rare in children, and results in kidney failure in up to one third of cases. There is very limited knowledge on kidney transplantation in childhood-onset AAV. We assessed kidney transplantation outcomes and prognostic factors in a multicentre cohort of patients with childhood-onset AAV.Methods: – Patients diagnosed with AAV during childhood (≤18 years) who received a kidney transplant were included in this retrospective study. We determined patient and graft survival, rates of chronic graft dysfunction (defined as eGFR
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Contribution to journal
publication status
published
subject
keywords
Adolescent, Age of Onset, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Child, Child, Preschool, Female, Glomerular Filtration Rate, Graft Rejection, Graft Survival, Humans, Kidney Transplantation, Male, Prognosis, Recurrence, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, adolescent, adverse event, ANCA associated vasculitis, child, clinical trial, complication, female, glomerulus filtration rate, graft rejection, graft survival, human, kidney transplantation, male, multicenter study, onset age, preschool child, prognosis, recurrent disease, retrospective study, risk factor, surgery, time factor, treatment outcome
in
Clinical Journal of the American Society of Nephrology
volume
21
issue
3
pages
14 pages
publisher
Amer Soc Nephrology
external identifiers
  • scopus:105032562450
  • pmid:41505217
ISSN
1555-9041
DOI
10.2215/CJN.0000000936
language
English
LU publication?
yes
id
d54125b1-9d40-4aa2-b353-ce376257578d
date added to LUP
2026-04-02 08:39:33
date last changed
2026-04-03 03:00:02
@article{d54125b1-9d40-4aa2-b353-ce376257578d,
  abstract     = {{Background: – Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is rare in children, and results in kidney failure in up to one third of cases. There is very limited knowledge on kidney transplantation in childhood-onset AAV. We assessed kidney transplantation outcomes and prognostic factors in a multicentre cohort of patients with childhood-onset AAV.Methods: – Patients diagnosed with AAV during childhood (≤18 years) who received a kidney transplant were included in this retrospective study. We determined patient and graft survival, rates of chronic graft dysfunction (defined as eGFR}},
  author       = {{Trivioli, G. and Mohammad, A.J. and Vaglio, Augusto}},
  issn         = {{1555-9041}},
  keywords     = {{Adolescent; Age of Onset; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Child; Child, Preschool; Female; Glomerular Filtration Rate; Graft Rejection; Graft Survival; Humans; Kidney Transplantation; Male; Prognosis; Recurrence; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; adolescent; adverse event; ANCA associated vasculitis; child; clinical trial; complication; female; glomerulus filtration rate; graft rejection; graft survival; human; kidney transplantation; male; multicenter study; onset age; preschool child; prognosis; recurrent disease; retrospective study; risk factor; surgery; time factor; treatment outcome}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{480--493}},
  publisher    = {{Amer Soc Nephrology}},
  series       = {{Clinical Journal of the American Society of Nephrology}},
  title        = {{Kidney Transplantation in Childhood-Onset Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Long-Term Outcomes and Prognostic Factors}},
  url          = {{http://dx.doi.org/10.2215/CJN.0000000936}},
  doi          = {{10.2215/CJN.0000000936}},
  volume       = {{21}},
  year         = {{2026}},
}