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Unleashing Ascl1 : Exploring Cross-Lineage Potential in Reprogramming and Regenerative Frontiers

Echegaray, Camila Vazquez LU orcid (2023) In Cellular Reprogramming 25(4). p.139-141
Abstract

In the era of stem cell research and regenerative medicine, understanding the regulatory networks that drive cellular reprogramming is fundamental. The study entitled ‘‘Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes’’ published in Stem Cell Reports sheds light on the remarkable versatility of Ascl1, a transcription factor known for its pivotal role in neurogenesis. By comparing regulatomes across multiple cell lineages, the authors have elucidated the potential of Ascl1 to facilitate the conversion of non-neural cells into various lineages beyond its canonical neural fate, suggesting its potential as a master regulator for lineage reprogramming. These observations challenge our current... (More)

In the era of stem cell research and regenerative medicine, understanding the regulatory networks that drive cellular reprogramming is fundamental. The study entitled ‘‘Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes’’ published in Stem Cell Reports sheds light on the remarkable versatility of Ascl1, a transcription factor known for its pivotal role in neurogenesis. By comparing regulatomes across multiple cell lineages, the authors have elucidated the potential of Ascl1 to facilitate the conversion of non-neural cells into various lineages beyond its canonical neural fate, suggesting its potential as a master regulator for lineage reprogramming. These observations challenge our current understanding of cell fate determination and open exciting avenues for regenerative medicine.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ascl1, direct reprogramming, epigenetics, Mef2c, regulator
in
Cellular Reprogramming
volume
25
issue
4
pages
3 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:37590007
  • scopus:85168246176
ISSN
2152-4971
DOI
10.1089/cell.2023.0080
language
English
LU publication?
yes
id
d5451cd8-fbad-40f9-bebc-96fb5e65cc24
date added to LUP
2023-10-31 14:04:00
date last changed
2024-04-19 03:10:00
@article{d5451cd8-fbad-40f9-bebc-96fb5e65cc24,
  abstract     = {{<p>In the era of stem cell research and regenerative medicine, understanding the regulatory networks that drive cellular reprogramming is fundamental. The study entitled ‘‘Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes’’ published in Stem Cell Reports sheds light on the remarkable versatility of Ascl1, a transcription factor known for its pivotal role in neurogenesis. By comparing regulatomes across multiple cell lineages, the authors have elucidated the potential of Ascl1 to facilitate the conversion of non-neural cells into various lineages beyond its canonical neural fate, suggesting its potential as a master regulator for lineage reprogramming. These observations challenge our current understanding of cell fate determination and open exciting avenues for regenerative medicine.</p>}},
  author       = {{Echegaray, Camila Vazquez}},
  issn         = {{2152-4971}},
  keywords     = {{Ascl1; direct reprogramming; epigenetics; Mef2c; regulator}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{139--141}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Cellular Reprogramming}},
  title        = {{Unleashing Ascl1 : Exploring Cross-Lineage Potential in Reprogramming and Regenerative Frontiers}},
  url          = {{http://dx.doi.org/10.1089/cell.2023.0080}},
  doi          = {{10.1089/cell.2023.0080}},
  volume       = {{25}},
  year         = {{2023}},
}