Advanced

Striatal changes in Parkinson disease : An investigation of morphology, functional connectivity and their relationship to clinical symptoms

Owens-Walton, Conor; Jakabek, David; Li, Xiaozhen LU ; Wilkes, Fiona A.; Walterfang, Mark; Velakoulis, Dennis; van Westen, Danielle LU ; Looi, Jeffrey C.L. and Hansson, Oskar LU (2018) In Psychiatry Research - Neuroimaging 275. p.5-13
Abstract

We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional connectivity using functional MRI data. Bilateral caudate nuclei and putamen volumes were significantly reduced in the PD cohort compared to controls. When looking at left and right hemispheres, the PD cohort had significantly smaller left caudate nucleus and right putamen volumes compared to controls. A significant correlation was found between... (More)

We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional connectivity using functional MRI data. Bilateral caudate nuclei and putamen volumes were significantly reduced in the PD cohort compared to controls. When looking at left and right hemispheres, the PD cohort had significantly smaller left caudate nucleus and right putamen volumes compared to controls. A significant correlation was found between greater atrophy of the caudate nucleus and poorer cognitive function, and between greater atrophy of the putamen and more severe motor symptoms. Resting-state functional MRI analysis revealed altered functional connectivity of the striatal structures in the PD group. This research demonstrates that PD involves atrophic changes to the caudate nucleus and putamen that are linked to clinical dysfunction. Our work reveals important information about a key structure-function relationship in the brain and provides support for caudate nucleus and putamen atrophy as neuroimaging biomeasures in PD.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Functional magnetic resonance imaging, Magnetic resonance imaging, Neostriatum, Neuroimaging
in
Psychiatry Research - Neuroimaging
volume
275
pages
5 - 13
publisher
Elsevier
external identifiers
  • scopus:85044000414
ISSN
0925-4927
DOI
10.1016/j.pscychresns.2018.03.004
language
English
LU publication?
yes
id
d5489646-6f2e-48dd-877e-16f8ec89475f
date added to LUP
2018-04-09 13:12:19
date last changed
2019-01-14 16:14:12
@article{d5489646-6f2e-48dd-877e-16f8ec89475f,
  abstract     = {<p>We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional connectivity using functional MRI data. Bilateral caudate nuclei and putamen volumes were significantly reduced in the PD cohort compared to controls. When looking at left and right hemispheres, the PD cohort had significantly smaller left caudate nucleus and right putamen volumes compared to controls. A significant correlation was found between greater atrophy of the caudate nucleus and poorer cognitive function, and between greater atrophy of the putamen and more severe motor symptoms. Resting-state functional MRI analysis revealed altered functional connectivity of the striatal structures in the PD group. This research demonstrates that PD involves atrophic changes to the caudate nucleus and putamen that are linked to clinical dysfunction. Our work reveals important information about a key structure-function relationship in the brain and provides support for caudate nucleus and putamen atrophy as neuroimaging biomeasures in PD.</p>},
  author       = {Owens-Walton, Conor and Jakabek, David and Li, Xiaozhen and Wilkes, Fiona A. and Walterfang, Mark and Velakoulis, Dennis and van Westen, Danielle and Looi, Jeffrey C.L. and Hansson, Oskar},
  issn         = {0925-4927},
  keyword      = {Functional magnetic resonance imaging,Magnetic resonance imaging,Neostriatum,Neuroimaging},
  language     = {eng},
  month        = {03},
  pages        = {5--13},
  publisher    = {Elsevier},
  series       = {Psychiatry Research - Neuroimaging},
  title        = {Striatal changes in Parkinson disease : An investigation of morphology, functional connectivity and their relationship to clinical symptoms},
  url          = {http://dx.doi.org/10.1016/j.pscychresns.2018.03.004},
  volume       = {275},
  year         = {2018},
}