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Detailed analysis of health-related quality of life after out-of-hospital cardiac arrest

Bohm, Mattias; Lilja, Gisela LU ; Finnbogadóttir, Hafrún LU ; Cronberg, Tobias LU ; Undén, Johan LU ; Friberg, Hans LU ; Kjærgaard, Jesper; Nielsen, Niklas LU ; Wise, Matt P. and Åkerman, Eva (2018) In Resuscitation
Abstract

Aim: To describe the detailed health-related quality of life (HRQoL) in survivors from the TTM-trial and to investigate potential differences related to sex and age. Methods: This is a cross-sectional study originating from a large prospective international, multicentre trial, including 442 respondents who answered the Short Form-36 item Questionnaire Health Survey version 2® (SF-36v2®) at a structured follow-up 6 months after out-of-hospital cardiac arrest (OHCA). Statistical analysis between independent groups were performed with Mann-Whitney U or Chi-square. Age was analysed primarily as a dichotomised variable. Results: Although overall physical and mental health were within the normal range, a substantial... (More)

Aim: To describe the detailed health-related quality of life (HRQoL) in survivors from the TTM-trial and to investigate potential differences related to sex and age. Methods: This is a cross-sectional study originating from a large prospective international, multicentre trial, including 442 respondents who answered the Short Form-36 item Questionnaire Health Survey version 2® (SF-36v2®) at a structured follow-up 6 months after out-of-hospital cardiac arrest (OHCA). Statistical analysis between independent groups were performed with Mann-Whitney U or Chi-square. Age was analysed primarily as a dichotomised variable. Results: Although overall physical and mental health were within the normal range, a substantial proportion of respondents had impaired function at domain-specific levels, particularly in Role-Physical (50%) and Role-Emotional (35%). Females scored significantly lower than males in; Physical Functioning (41.7 vs. 47.9, p < 0.001), Role-Physical (40.4 vs. 44.3, p = 0.02), General Health (47.0 vs. 50.5, p = 0.02), Vitality (47.2 vs. 52.7, p < 0.001), and Role-Emotional (41.5 vs. 46.2, p = 0.009). Those ≤65 years scored significantly better in Physical Functioning (47.9 vs. 44.1 p < 0.001), while those >65 years scored significantly better in Vitality (50.8 vs. 53.7, p = 0.006) and Mental Health (50.3 vs. 52.6, p = 0.04). Conclusions: Many OHCA survivors demonstrated impaired function in HRQoL at a domain level, despite most patients reporting an acceptable general HRQoL. Females reported worse HRQoL than males. Older age was associated with a worse Physical Functioning but better Vitality and Mental Health. Role-Physical and Role-Emotional aspects of health were especially affected, even when effects of age and sex where accounted for.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Cardiac arrest, Cross-sectional studies, Outcome, Quality of life, SF-36v2
in
Resuscitation
publisher
Elsevier
external identifiers
  • scopus:85060137305
ISSN
0300-9572
DOI
10.1016/j.resuscitation.2018.10.028
language
English
LU publication?
yes
id
d55889c9-d67f-4a27-8724-7275067ecb7d
date added to LUP
2019-01-30 08:57:46
date last changed
2019-03-19 04:04:41
@article{d55889c9-d67f-4a27-8724-7275067ecb7d,
  abstract     = {<p>Aim: To describe the detailed health-related quality of life (HRQoL) in survivors from the TTM-trial and to investigate potential differences related to sex and age. Methods: This is a cross-sectional study originating from a large prospective international, multicentre trial, including 442 respondents who answered the Short Form-36 item Questionnaire Health Survey version 2<sup>®</sup> (SF-36v2<sup>®</sup>) at a structured follow-up 6 months after out-of-hospital cardiac arrest (OHCA). Statistical analysis between independent groups were performed with Mann-Whitney U or Chi-square. Age was analysed primarily as a dichotomised variable. Results: Although overall physical and mental health were within the normal range, a substantial proportion of respondents had impaired function at domain-specific levels, particularly in Role-Physical (50%) and Role-Emotional (35%). Females scored significantly lower than males in; Physical Functioning (41.7 vs. 47.9, p &lt; 0.001), Role-Physical (40.4 vs. 44.3, p = 0.02), General Health (47.0 vs. 50.5, p = 0.02), Vitality (47.2 vs. 52.7, p &lt; 0.001), and Role-Emotional (41.5 vs. 46.2, p = 0.009). Those ≤65 years scored significantly better in Physical Functioning (47.9 vs. 44.1 p &lt; 0.001), while those &gt;65 years scored significantly better in Vitality (50.8 vs. 53.7, p = 0.006) and Mental Health (50.3 vs. 52.6, p = 0.04). Conclusions: Many OHCA survivors demonstrated impaired function in HRQoL at a domain level, despite most patients reporting an acceptable general HRQoL. Females reported worse HRQoL than males. Older age was associated with a worse Physical Functioning but better Vitality and Mental Health. Role-Physical and Role-Emotional aspects of health were especially affected, even when effects of age and sex where accounted for.</p>},
  author       = {Bohm, Mattias and Lilja, Gisela and Finnbogadóttir, Hafrún and Cronberg, Tobias and Undén, Johan and Friberg, Hans and Kjærgaard, Jesper and Nielsen, Niklas and Wise, Matt P. and Åkerman, Eva},
  issn         = {0300-9572},
  keyword      = {Cardiac arrest,Cross-sectional studies,Outcome,Quality of life,SF-36v2},
  language     = {eng},
  month        = {10},
  publisher    = {Elsevier},
  series       = {Resuscitation},
  title        = {Detailed analysis of health-related quality of life after out-of-hospital cardiac arrest},
  url          = {http://dx.doi.org/10.1016/j.resuscitation.2018.10.028},
  year         = {2018},
}