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Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.

Danielsen, Stine A ; Lind, Guro E ; Kolberg, Matthias ; Høland, Maren ; Bjerkehagen, Bodil ; Sundby Hall, Kirsten ; van den Berg, Eva ; Mertens, Fredrik LU ; Smeland, Sigbjørn and Picci, Piero , et al. (2015) In Neuro-Oncology 17(1). p.63-69
Abstract
Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuro-Oncology
volume
17
issue
1
pages
63 - 69
publisher
Oxford University Press
external identifiers
  • pmid:25038505
  • wos:000350138000008
  • scopus:84922572928
  • pmid:25038505
ISSN
1523-5866
DOI
10.1093/neuonc/nou140
language
English
LU publication?
yes
id
d55f9678-30ec-4c72-8c5a-e0cd07230499 (old id 4581914)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25038505?dopt=Abstract
date added to LUP
2016-04-01 11:12:30
date last changed
2022-04-12 21:11:52
@article{d55f9678-30ec-4c72-8c5a-e0cd07230499,
  abstract     = {{Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled.}},
  author       = {{Danielsen, Stine A and Lind, Guro E and Kolberg, Matthias and Høland, Maren and Bjerkehagen, Bodil and Sundby Hall, Kirsten and van den Berg, Eva and Mertens, Fredrik and Smeland, Sigbjørn and Picci, Piero and Lothe, Ragnhild A}},
  issn         = {{1523-5866}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{63--69}},
  publisher    = {{Oxford University Press}},
  series       = {{Neuro-Oncology}},
  title        = {{Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.}},
  url          = {{https://lup.lub.lu.se/search/files/2470145/8310865.pdf}},
  doi          = {{10.1093/neuonc/nou140}},
  volume       = {{17}},
  year         = {{2015}},
}