The minor collagens in articular cartilage
Luo, Yunyun ; Sinkeviciute, Dovile LU ; He, Yi ; Karsdal, Morten A ; Henrotin, Yves ; Mobasheri, Ali ; Önnerfjord, Patrik LU
and Bay-Jensen, Anne
(2017)
In Protein and Cell
8(8).
p.560-572
- Abstract
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective... (More)
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including these minor collagens. The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials.
(Less)
- author
- Luo, Yunyun
; Sinkeviciute, Dovile
LU
; He, Yi
; Karsdal, Morten A
; Henrotin, Yves
; Mobasheri, Ali
; Önnerfjord, Patrik
LU
and Bay-Jensen, Anne
- organization
- publishing date
- 2017-02-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- arthritis, biomarker, collagen
- in
- Protein and Cell
- volume
- 8
- issue
- 8
- pages
- 560 - 572
- publisher
- Springer
- external identifiers
-
- pmid:28213717
- wos:000407002200003
- scopus:85013130516
- ISSN
- 1674-800X
- DOI
- 10.1007/s13238-017-0377-7
- project
- Joint disease biomarkers – discovery and application
- language
- English
- LU publication?
- yes
- id
- d563f3a4-b996-4f2a-9ce7-fec5aa1ad655
- date added to LUP
- 2017-03-01 09:47:21
- date last changed
- 2024-06-10 14:35:40
@article{d563f3a4-b996-4f2a-9ce7-fec5aa1ad655,
abstract = {{<p>Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including these minor collagens. The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials.</p>}},
author = {{Luo, Yunyun and Sinkeviciute, Dovile and He, Yi and Karsdal, Morten A and Henrotin, Yves and Mobasheri, Ali and Önnerfjord, Patrik and Bay-Jensen, Anne}},
issn = {{1674-800X}},
keywords = {{arthritis; biomarker; collagen}},
language = {{eng}},
month = {{02}},
number = {{8}},
pages = {{560--572}},
publisher = {{Springer}},
series = {{Protein and Cell}},
title = {{The minor collagens in articular cartilage}},
url = {{http://dx.doi.org/10.1007/s13238-017-0377-7}},
doi = {{10.1007/s13238-017-0377-7}},
volume = {{8}},
year = {{2017}},
}