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The minor collagens in articular cartilage

Luo, Yunyun; Sinkeviciute, Dovile LU ; He, Yi; Karsdal, Morten A; Henrotin, Yves; Mobasheri, Ali; Önnerfjord, Patrik LU and Bay-Jensen, Anne (2017) In Protein and Cell 8(8). p.560-572
Abstract

Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective... (More)

Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including these minor collagens. The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arthritis, biomarker, collagen
in
Protein and Cell
volume
8
issue
8
pages
560 - 572
publisher
Springer-Verlag GmbH and Co. KG
external identifiers
  • scopus:85013130516
  • wos:000407002200003
ISSN
1674-800X
DOI
10.1007/s13238-017-0377-7
language
English
LU publication?
yes
id
d563f3a4-b996-4f2a-9ce7-fec5aa1ad655
date added to LUP
2017-03-01 09:47:21
date last changed
2018-01-07 11:53:26
@article{d563f3a4-b996-4f2a-9ce7-fec5aa1ad655,
  abstract     = {<p>Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including these minor collagens. The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials.</p>},
  author       = {Luo, Yunyun and Sinkeviciute, Dovile and He, Yi and Karsdal, Morten A and Henrotin, Yves and Mobasheri, Ali and Önnerfjord, Patrik and Bay-Jensen, Anne},
  issn         = {1674-800X},
  keyword      = {arthritis,biomarker,collagen},
  language     = {eng},
  month        = {02},
  number       = {8},
  pages        = {560--572},
  publisher    = {Springer-Verlag GmbH and Co. KG},
  series       = {Protein and Cell},
  title        = {The minor collagens in articular cartilage},
  url          = {http://dx.doi.org/10.1007/s13238-017-0377-7},
  volume       = {8},
  year         = {2017},
}