Stem cell aging and wound healing
(2021) p.53-60- Abstract
Aging is a natural process that promotes different pathologies and progressive functional losses of cells and tissues. Aging impacts stem cell reserve and function negatively, resulting in compromising tissue regeneration. Stem cell aging significantly impairs wound healing properties of different tissues due to the age-related aberrant changes like increased proinflammatory cytokines, accumulation of toxic metabolites, and senescence-associated molecules in the systemic milieu. The cascade of improper structural alterations leading to fibrosis is a serious concern in aged tissues upon injury due to the increased thickness/stiffness of extracellular matrix intermediated by matrix metalloproteinases. The aged-associated defects in the... (More)
Aging is a natural process that promotes different pathologies and progressive functional losses of cells and tissues. Aging impacts stem cell reserve and function negatively, resulting in compromising tissue regeneration. Stem cell aging significantly impairs wound healing properties of different tissues due to the age-related aberrant changes like increased proinflammatory cytokines, accumulation of toxic metabolites, and senescence-associated molecules in the systemic milieu. The cascade of improper structural alterations leading to fibrosis is a serious concern in aged tissues upon injury due to the increased thickness/stiffness of extracellular matrix intermediated by matrix metalloproteinases. The aged-associated defects in the stem cell function can be revived by applying various exogenous interventions aiming at upregulating optimal reparative conditions for aged tissues. Thus, this chapter briefly covers the factors linked to impaired wound healing due to stem cell aging and enlists alternative treatment strategies to regulate tissue regeneration in aging.
(Less)
- author
- Rajendran, Vijayalakshmi LU ; Jain, Mayur Vilas LU and Sharma, Sumit
- organization
- publishing date
- 2021-01-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Extracellular matrix, Fibrosis, Matrix metalloproteinases, Senescence, Stem cell aging, Tissue regeneration
- host publication
- Stem Cells and Aging
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85128530101
- ISBN
- 9780128200711
- DOI
- 10.1016/B978-0-12-820071-1.00019-0
- language
- English
- LU publication?
- yes
- id
- d595d6ff-35c7-45bb-8f52-278689808ea7
- date added to LUP
- 2022-06-15 14:12:58
- date last changed
- 2024-09-17 11:07:35
@inbook{d595d6ff-35c7-45bb-8f52-278689808ea7,
abstract = {{<p>Aging is a natural process that promotes different pathologies and progressive functional losses of cells and tissues. Aging impacts stem cell reserve and function negatively, resulting in compromising tissue regeneration. Stem cell aging significantly impairs wound healing properties of different tissues due to the age-related aberrant changes like increased proinflammatory cytokines, accumulation of toxic metabolites, and senescence-associated molecules in the systemic milieu. The cascade of improper structural alterations leading to fibrosis is a serious concern in aged tissues upon injury due to the increased thickness/stiffness of extracellular matrix intermediated by matrix metalloproteinases. The aged-associated defects in the stem cell function can be revived by applying various exogenous interventions aiming at upregulating optimal reparative conditions for aged tissues. Thus, this chapter briefly covers the factors linked to impaired wound healing due to stem cell aging and enlists alternative treatment strategies to regulate tissue regeneration in aging.</p>}},
author = {{Rajendran, Vijayalakshmi and Jain, Mayur Vilas and Sharma, Sumit}},
booktitle = {{Stem Cells and Aging}},
isbn = {{9780128200711}},
keywords = {{Extracellular matrix; Fibrosis; Matrix metalloproteinases; Senescence; Stem cell aging; Tissue regeneration}},
language = {{eng}},
month = {{01}},
pages = {{53--60}},
publisher = {{Elsevier}},
title = {{Stem cell aging and wound healing}},
url = {{http://dx.doi.org/10.1016/B978-0-12-820071-1.00019-0}},
doi = {{10.1016/B978-0-12-820071-1.00019-0}},
year = {{2021}},
}