Preoperative platelet-rich plasmapheresis and hemodilution with an autotransfusion device in total hip replacement surgery.
(2000) In Journal of Clinical Apheresis 15(4). p.256-261- Abstract
- The effectiveness of both preoperative autologous donation (PAD) and intraoperative autotransfusion (IAT) with an autotransfusion device has recently been questioned. Preoperative apheresis, with separation of concentrated platelet rich-plasma (c-PRP) and erythrocyte concentrate (ERC), represents an aggressive use of the autotransfusion device. Can such a procedure replace PAD in total hip replacement surgery (THR)? Eighty patients undergoing THR were investigated in a prospective and randomized study. Forty patients underwent PAD, and 2 units of ERC + plasma were retrieved within 4 weeks preoperatively. Another 40 patients underwent an immediately preoperative apheresis with a concomitant hemodilution with 4% albumin, retrieving c-PRP... (More)
- The effectiveness of both preoperative autologous donation (PAD) and intraoperative autotransfusion (IAT) with an autotransfusion device has recently been questioned. Preoperative apheresis, with separation of concentrated platelet rich-plasma (c-PRP) and erythrocyte concentrate (ERC), represents an aggressive use of the autotransfusion device. Can such a procedure replace PAD in total hip replacement surgery (THR)? Eighty patients undergoing THR were investigated in a prospective and randomized study. Forty patients underwent PAD, and 2 units of ERC + plasma were retrieved within 4 weeks preoperatively. Another 40 patients underwent an immediately preoperative apheresis with a concomitant hemodilution with 4% albumin, retrieving c-PRP (30% of the platelet pool) and 2 units of ERC. Both groups used IAT up to 2 hours postoperatively, with 3% dextran-60 as a plasma substitute according to our standard of care. There were no differences in blood loss, B-hemoglobin or allogeneic transfusions between the groups: 85% of the patients did not receive allogeneic blood. Both apheresis and reinfusion of c-PRP had minor impact on the coagulation parameters. Platelet count increased slightly but significantly (P<0.05) from 154 to 179 x 10(9)/L after the c-PRP at wound closure. Preoperative apheresis with an autotransfusion device, separating platelet-rich plasma and erythrocyte concentrate, is a useful alternative for patients who are unable to utilize the PAD technique for either religious or practical reasons. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3634352
- author
- Ekbäck, G ; Ryttberg, L ; Axelsson, K ; Christianssen, F ; Kjellberg, J ; Carlsson, P ; Carlsson, O and Schött, Ulf LU
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Blood Transfusion, Autologous: instrumentation
- in
- Journal of Clinical Apheresis
- volume
- 15
- issue
- 4
- pages
- 256 - 261
- publisher
- Wiley
- external identifiers
-
- pmid:11124694
- scopus:0034525338
- ISSN
- 0733-2459
- project
- Koagulation vid kirurgi och kritisk sjukdom
- language
- English
- LU publication?
- no
- id
- d5b13181-97b2-43f9-a5b7-a6098905cd02 (old id 3634352)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/11124694?dopt=Abstract
- date added to LUP
- 2016-04-04 07:23:25
- date last changed
- 2022-03-07 20:14:10
@article{d5b13181-97b2-43f9-a5b7-a6098905cd02,
abstract = {{The effectiveness of both preoperative autologous donation (PAD) and intraoperative autotransfusion (IAT) with an autotransfusion device has recently been questioned. Preoperative apheresis, with separation of concentrated platelet rich-plasma (c-PRP) and erythrocyte concentrate (ERC), represents an aggressive use of the autotransfusion device. Can such a procedure replace PAD in total hip replacement surgery (THR)? Eighty patients undergoing THR were investigated in a prospective and randomized study. Forty patients underwent PAD, and 2 units of ERC + plasma were retrieved within 4 weeks preoperatively. Another 40 patients underwent an immediately preoperative apheresis with a concomitant hemodilution with 4% albumin, retrieving c-PRP (30% of the platelet pool) and 2 units of ERC. Both groups used IAT up to 2 hours postoperatively, with 3% dextran-60 as a plasma substitute according to our standard of care. There were no differences in blood loss, B-hemoglobin or allogeneic transfusions between the groups: 85% of the patients did not receive allogeneic blood. Both apheresis and reinfusion of c-PRP had minor impact on the coagulation parameters. Platelet count increased slightly but significantly (P<0.05) from 154 to 179 x 10(9)/L after the c-PRP at wound closure. Preoperative apheresis with an autotransfusion device, separating platelet-rich plasma and erythrocyte concentrate, is a useful alternative for patients who are unable to utilize the PAD technique for either religious or practical reasons.}},
author = {{Ekbäck, G and Ryttberg, L and Axelsson, K and Christianssen, F and Kjellberg, J and Carlsson, P and Carlsson, O and Schött, Ulf}},
issn = {{0733-2459}},
keywords = {{Blood Transfusion; Autologous: instrumentation}},
language = {{eng}},
number = {{4}},
pages = {{256--261}},
publisher = {{Wiley}},
series = {{Journal of Clinical Apheresis}},
title = {{Preoperative platelet-rich plasmapheresis and hemodilution with an autotransfusion device in total hip replacement surgery.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/11124694?dopt=Abstract}},
volume = {{15}},
year = {{2000}},
}