The association between smoking and knee osteoarthritis in a cohort of Danish patients undergoing knee arthroscopy
Johnsen, Marianne Bakke ; Pihl, Kenneth ; Nissen, Nis ; Sørensen, Rasmus Reinholdt ; Jørgensen, Uffe ; Englund, Martin LU
and Thorlund, Jonas Bloch
(2019)
In BMC Musculoskeletal Disorders
20(1).
- Abstract
Background: It has been suggested that smoking is associated with reduced risk of knee osteoarthritis (OA). However, supplementary studies are needed to further investigate any such potential association. Thus, our aim was to examine the relationship between smoking and early or more established knee OA in a cohort of relatively young patients with meniscal tears. Methods: This cross-sectional study included 620 participants from the Knee Arthroscopy Cohort Southern Denmark (KACS) undergoing knee arthroscopy for a meniscal tear (mean age 49.2 (18.0-76.8) years). Recruitment of patients was performed between February 1, 2013, and January 31, 2015, at four different hospitals in Denmark. We defined early or more established knee OA as the... (More)
Background: It has been suggested that smoking is associated with reduced risk of knee osteoarthritis (OA). However, supplementary studies are needed to further investigate any such potential association. Thus, our aim was to examine the relationship between smoking and early or more established knee OA in a cohort of relatively young patients with meniscal tears. Methods: This cross-sectional study included 620 participants from the Knee Arthroscopy Cohort Southern Denmark (KACS) undergoing knee arthroscopy for a meniscal tear (mean age 49.2 (18.0-76.8) years). Recruitment of patients was performed between February 1, 2013, and January 31, 2015, at four different hospitals in Denmark. We defined early or more established knee OA as the combination of patient-reported frequent knee pain, degenerative meniscal tissue and presence of cartilage defects assessed by the operating surgeons. The relationship between smoking status and knee OA was examined by risk ratio (RR) with a 95% confidence interval (CI), estimated from logistic regression adjusted for age, sex, BMI, education, work status and level of physical activity. Results: The prevalence of early or more established knee OA was 37.7% in current smokers and 45.0% in non-smokers. We found no statistically significant association between current smoking and knee OA (adjusted RR 1.09, 95% CI 0.91-1.30). Conclusions: This study found no relationship between current smoking and early or more established knee OA in a cohort of patients undergoing arthroscopic meniscal surgery. Thus, the inverse association between smoking and knee OA that has been suggested by previous studies was not confirmed.
(Less)
- author
- Johnsen, Marianne Bakke
; Pihl, Kenneth
; Nissen, Nis
; Sørensen, Rasmus Reinholdt
; Jørgensen, Uffe
; Englund, Martin
LU
and Thorlund, Jonas Bloch
- organization
- publishing date
- 2019-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Knee arthroscopy, Knee osteoarthritis, Meniscal tear, Risk factor, Smoking
- in
- BMC Musculoskeletal Disorders
- volume
- 20
- issue
- 1
- article number
- 141
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85063814997
- pmid:30935365
- ISSN
- 1471-2474
- DOI
- 10.1186/s12891-019-2518-z
- language
- English
- LU publication?
- yes
- id
- d5b47409-6cf8-4260-affe-c2ff8edaee93
- date added to LUP
- 2019-04-23 13:15:01
- date last changed
- 2024-04-30 05:09:36
@article{d5b47409-6cf8-4260-affe-c2ff8edaee93,
abstract = {{<p>Background: It has been suggested that smoking is associated with reduced risk of knee osteoarthritis (OA). However, supplementary studies are needed to further investigate any such potential association. Thus, our aim was to examine the relationship between smoking and early or more established knee OA in a cohort of relatively young patients with meniscal tears. Methods: This cross-sectional study included 620 participants from the Knee Arthroscopy Cohort Southern Denmark (KACS) undergoing knee arthroscopy for a meniscal tear (mean age 49.2 (18.0-76.8) years). Recruitment of patients was performed between February 1, 2013, and January 31, 2015, at four different hospitals in Denmark. We defined early or more established knee OA as the combination of patient-reported frequent knee pain, degenerative meniscal tissue and presence of cartilage defects assessed by the operating surgeons. The relationship between smoking status and knee OA was examined by risk ratio (RR) with a 95% confidence interval (CI), estimated from logistic regression adjusted for age, sex, BMI, education, work status and level of physical activity. Results: The prevalence of early or more established knee OA was 37.7% in current smokers and 45.0% in non-smokers. We found no statistically significant association between current smoking and knee OA (adjusted RR 1.09, 95% CI 0.91-1.30). Conclusions: This study found no relationship between current smoking and early or more established knee OA in a cohort of patients undergoing arthroscopic meniscal surgery. Thus, the inverse association between smoking and knee OA that has been suggested by previous studies was not confirmed.</p>}},
author = {{Johnsen, Marianne Bakke and Pihl, Kenneth and Nissen, Nis and Sørensen, Rasmus Reinholdt and Jørgensen, Uffe and Englund, Martin and Thorlund, Jonas Bloch}},
issn = {{1471-2474}},
keywords = {{Knee arthroscopy; Knee osteoarthritis; Meniscal tear; Risk factor; Smoking}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Musculoskeletal Disorders}},
title = {{The association between smoking and knee osteoarthritis in a cohort of Danish patients undergoing knee arthroscopy}},
url = {{http://dx.doi.org/10.1186/s12891-019-2518-z}},
doi = {{10.1186/s12891-019-2518-z}},
volume = {{20}},
year = {{2019}},
}