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Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome

Bloch, M H ; Peterson, B S ; Scahill, L ; Otka, J ; Katsovich, L ; Zhang, H and Leckman, J F (2006) In Archives of Pediatrics & Adolescent Medicine 160(1). p.65-69
Abstract
BACKGROUND: Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder that is characterized by both motor and phonic tics. One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD). OBJECTIVES: To clarify the clinical course of tic and OCD symptoms in children with TS and determine if baseline clinical measurements in childhood are associated with future symptom severity in late adolescence and early adulthood. DESIGN: Prospective cohort study. SETTING: Yale Child Study Center tic and OCD outpatient specialty clinic. PARTICIPANTS: Forty-six children with TS who received a... (More)
BACKGROUND: Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder that is characterized by both motor and phonic tics. One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD). OBJECTIVES: To clarify the clinical course of tic and OCD symptoms in children with TS and determine if baseline clinical measurements in childhood are associated with future symptom severity in late adolescence and early adulthood. DESIGN: Prospective cohort study. SETTING: Yale Child Study Center tic and OCD outpatient specialty clinic. PARTICIPANTS: Forty-six children with TS who received a structured clinical evaluation prior to age 14 years. MAIN OUTCOME MEASURES: Expert-rated tic and OCD symptom severity at follow-up interview an average of 7.6 years later (range, 3.8-12.8 years). RESULTS: Eighty-five percent of subjects reported a reduction in tic symptoms during adolescence. Only increased tic severity in childhood was associated with increased tic severity at follow-up. The average age at worst-ever tic severity was 10.6 years. Forty-one percent of patients with TS reported at one time experiencing at least moderate OCD symptoms. Worst-ever OCD symptoms occurred approximately 2 years later than worst-ever tic symptoms. Increased childhood IQ was strongly associated with increased OCD severity at follow-up. CONCLUSION: Obsessive-compulsive disorder symptoms in children with TS became more severe at a later age and were more likely to persist than tic symptoms. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Pediatrics & Adolescent Medicine
volume
160
issue
1
pages
65 - 69
publisher
American Medical Association
external identifiers
  • scopus:29944432148
  • pmid:16389213
ISSN
1072-4710
DOI
10.1001/archpedi.160.1.65
language
English
LU publication?
no
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Faculty office (013100001)
id
d5c3e664-1ac5-4b07-8abc-30f1e497fe06 (old id 1136699)
date added to LUP
2016-04-01 16:43:02
date last changed
2022-04-15 06:32:57
@article{d5c3e664-1ac5-4b07-8abc-30f1e497fe06,
  abstract     = {{BACKGROUND: Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder that is characterized by both motor and phonic tics. One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD). OBJECTIVES: To clarify the clinical course of tic and OCD symptoms in children with TS and determine if baseline clinical measurements in childhood are associated with future symptom severity in late adolescence and early adulthood. DESIGN: Prospective cohort study. SETTING: Yale Child Study Center tic and OCD outpatient specialty clinic. PARTICIPANTS: Forty-six children with TS who received a structured clinical evaluation prior to age 14 years. MAIN OUTCOME MEASURES: Expert-rated tic and OCD symptom severity at follow-up interview an average of 7.6 years later (range, 3.8-12.8 years). RESULTS: Eighty-five percent of subjects reported a reduction in tic symptoms during adolescence. Only increased tic severity in childhood was associated with increased tic severity at follow-up. The average age at worst-ever tic severity was 10.6 years. Forty-one percent of patients with TS reported at one time experiencing at least moderate OCD symptoms. Worst-ever OCD symptoms occurred approximately 2 years later than worst-ever tic symptoms. Increased childhood IQ was strongly associated with increased OCD severity at follow-up. CONCLUSION: Obsessive-compulsive disorder symptoms in children with TS became more severe at a later age and were more likely to persist than tic symptoms.}},
  author       = {{Bloch, M H and Peterson, B S and Scahill, L and Otka, J and Katsovich, L and Zhang, H and Leckman, J F}},
  issn         = {{1072-4710}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{65--69}},
  publisher    = {{American Medical Association}},
  series       = {{Archives of Pediatrics & Adolescent Medicine}},
  title        = {{Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome}},
  url          = {{http://dx.doi.org/10.1001/archpedi.160.1.65}},
  doi          = {{10.1001/archpedi.160.1.65}},
  volume       = {{160}},
  year         = {{2006}},
}