STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Pena, Cristina ; Virtudes Cespedes, Maria ; Lindh, Maja Bradic ; Kiflemariam, Sara ; Mezheyeuski, Artur ; Edqvist, Per-Henrik ; Hagglof, Christina ; Birgisson, Helgi ; Bojmar, Linda and Jirström, Karin LU
, et al.
(2013)
In Cancer Research
74(4).
p.1287-1297
- Abstract
- Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic... (More)
- Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. Our results reveal a mechanistic basis for understanding the contribution of PDGF-activated CAFs to cancer metastasis. Cancer Res; 73(4); 1287-97. (C) 2012 AACR. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3577884
- author
- Pena, Cristina
; Virtudes Cespedes, Maria
; Lindh, Maja Bradic
; Kiflemariam, Sara
; Mezheyeuski, Artur
; Edqvist, Per-Henrik
; Hagglof, Christina
; Birgisson, Helgi
; Bojmar, Linda
and Jirström, Karin
LU
, et al. (More)
- Pena, Cristina
; Virtudes Cespedes, Maria
; Lindh, Maja Bradic
; Kiflemariam, Sara
; Mezheyeuski, Artur
; Edqvist, Per-Henrik
; Hagglof, Christina
; Birgisson, Helgi
; Bojmar, Linda
; Jirström, Karin
LU
; Sandstrom, Per
; Olsson, Eleonor
LU
; Veerla, Srinivas
LU
; Gallardo, Alberto
; Sjoblom, Tobias
; Chang, Andy C. -M.
; Reddel, Roger R.
; Mangues, Ramon
; Augsten, Martin
and Ostman, Arne
(Less)
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Research
- volume
- 74
- issue
- 4
- pages
- 1287 - 1297
- publisher
- American Association for Cancer Research Inc.
- external identifiers
-
- wos:000315029800004
- scopus:84874336387
- pmid:23243022
- ISSN
- 1538-7445
- DOI
- 10.1158/0008-5472.CAN-12-1875
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)
- id
- d5d4f188-5eae-447b-8c5e-0520b9e878b6 (old id 3577884)
- date added to LUP
- 2016-04-01 14:20:19
- date last changed
- 2024-02-08 14:53:41
@article{d5d4f188-5eae-447b-8c5e-0520b9e878b6,
abstract = {{Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. Our results reveal a mechanistic basis for understanding the contribution of PDGF-activated CAFs to cancer metastasis. Cancer Res; 73(4); 1287-97. (C) 2012 AACR.}},
author = {{Pena, Cristina and Virtudes Cespedes, Maria and Lindh, Maja Bradic and Kiflemariam, Sara and Mezheyeuski, Artur and Edqvist, Per-Henrik and Hagglof, Christina and Birgisson, Helgi and Bojmar, Linda and Jirström, Karin and Sandstrom, Per and Olsson, Eleonor and Veerla, Srinivas and Gallardo, Alberto and Sjoblom, Tobias and Chang, Andy C. -M. and Reddel, Roger R. and Mangues, Ramon and Augsten, Martin and Ostman, Arne}},
issn = {{1538-7445}},
language = {{eng}},
number = {{4}},
pages = {{1287--1297}},
publisher = {{American Association for Cancer Research Inc.}},
series = {{Cancer Research}},
title = {{STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer}},
url = {{http://dx.doi.org/10.1158/0008-5472.CAN-12-1875}},
doi = {{10.1158/0008-5472.CAN-12-1875}},
volume = {{74}},
year = {{2013}},
}