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Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization

Wang, Peng Chao ; Liu, Jie ; Liu, Yue Fang ; Wu, Yang ; Xue, Lin Li and Yang, Zhen Shan LU orcid (2025) In BMC Veterinary Research 21(1).
Abstract

Background: Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear. Results: This study showed that mPGES1 was highly expressed in the mouse uterus’s subluminal stromal cells at the implantation site. COX2-specific inhibitor Valdecoxib and mPGES1 selective inhibitor MK886 were used to analyze the roles of mPGES1 and COX2 during mouse and human decidualization. During mouse in vitro decidualization, decidua/trophoblast prolactin-related protein (Dtprp) expression was significantly suppressed by Valdecoxib and MK886. Under human in vitro decidualization, mPGES1 significantly increases, while both cPGES and mPGES2 remain... (More)

Background: Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear. Results: This study showed that mPGES1 was highly expressed in the mouse uterus’s subluminal stromal cells at the implantation site. COX2-specific inhibitor Valdecoxib and mPGES1 selective inhibitor MK886 were used to analyze the roles of mPGES1 and COX2 during mouse and human decidualization. During mouse in vitro decidualization, decidua/trophoblast prolactin-related protein (Dtprp) expression was significantly suppressed by Valdecoxib and MK886. Under human in vitro decidualization, mPGES1 significantly increases, while both cPGES and mPGES2 remain unchanged. PGE2-mediated upregulation of insulin growth factor binding protein 1 (IGFBP1) was significantly inhibited by Valdecoxib and MK886. Conclusions: Our findings suggest the involvement of COX2/mPGES1/PGE2 pathway in both mouse and human decidualization.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
COX2, Decidualization, Endometrial stromal cell, mPGES1, PGE2
in
BMC Veterinary Research
volume
21
issue
1
article number
43
publisher
BioMed Central (BMC)
external identifiers
  • pmid:39885565
  • scopus:85217357902
ISSN
1746-6148
DOI
10.1186/s12917-025-04505-5
language
English
LU publication?
yes
id
d5de3fd5-6b0e-4f69-bca8-1a35ef538bdb
date added to LUP
2025-03-20 13:51:20
date last changed
2025-07-10 22:34:23
@article{d5de3fd5-6b0e-4f69-bca8-1a35ef538bdb,
  abstract     = {{<p>Background: Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear. Results: This study showed that mPGES1 was highly expressed in the mouse uterus’s subluminal stromal cells at the implantation site. COX2-specific inhibitor Valdecoxib and mPGES1 selective inhibitor MK886 were used to analyze the roles of mPGES1 and COX2 during mouse and human decidualization. During mouse in vitro decidualization, decidua/trophoblast prolactin-related protein (Dtprp) expression was significantly suppressed by Valdecoxib and MK886. Under human in vitro decidualization, mPGES1 significantly increases, while both cPGES and mPGES2 remain unchanged. PGE2-mediated upregulation of insulin growth factor binding protein 1 (IGFBP1) was significantly inhibited by Valdecoxib and MK886. Conclusions: Our findings suggest the involvement of COX2/mPGES1/PGE2 pathway in both mouse and human decidualization.</p>}},
  author       = {{Wang, Peng Chao and Liu, Jie and Liu, Yue Fang and Wu, Yang and Xue, Lin Li and Yang, Zhen Shan}},
  issn         = {{1746-6148}},
  keywords     = {{COX2; Decidualization; Endometrial stromal cell; mPGES1; PGE2}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Veterinary Research}},
  title        = {{Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization}},
  url          = {{http://dx.doi.org/10.1186/s12917-025-04505-5}},
  doi          = {{10.1186/s12917-025-04505-5}},
  volume       = {{21}},
  year         = {{2025}},
}