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Variation and covariation in patch test reactivity to palladium and nickel salts

Rosholm Comstedt, Lisbeth LU ; Engfeldt, Malin ; Svedman, Cecilia LU ; Åkesson, Anna LU ; Hindsén, Monica LU and Bruze, Magnus LU (2018) In European journal of dermatology : EJD 28(5). p.668-676
Abstract

Concomitant reactions to palladium chloride (PdCl2), sodium tetrachloropalladate (Na2PdCl4), and nickel hexahydrate sulphate (NiSO4·6H2O) are very common during patch testing and have mainly been explained by cross-sensitisation. Whether there is variation in reactivity to palladium or covariation to nickel and palladium is not known. The aim of this study was to investigate the variation in patch test reactivity to PdCl2 and Na2PdCl4 over time and compare this to variation in patch test reactivity to NiSO4·6H2O. Fifteen females known to be sensitised to nickel and palladium were patch tested four times with 12-week intervals using a dilution series of NiSO4·6H2O, PdCl2 or Na2PdCl4. Patch test reactivity to Na2PdCl4 was less variable... (More)

Concomitant reactions to palladium chloride (PdCl2), sodium tetrachloropalladate (Na2PdCl4), and nickel hexahydrate sulphate (NiSO4·6H2O) are very common during patch testing and have mainly been explained by cross-sensitisation. Whether there is variation in reactivity to palladium or covariation to nickel and palladium is not known. The aim of this study was to investigate the variation in patch test reactivity to PdCl2 and Na2PdCl4 over time and compare this to variation in patch test reactivity to NiSO4·6H2O. Fifteen females known to be sensitised to nickel and palladium were patch tested four times with 12-week intervals using a dilution series of NiSO4·6H2O, PdCl2 or Na2PdCl4. Patch test reactivity to Na2PdCl4 was less variable compared to that for NiSO4·6H2O or PdCl2. All test salts showed higher patch test reactivity during wintertime. No significant correlation was observed between the variation in patch test reactivity to Na2PdCl4 and PdCl2 and the variation in patch test reactivity to NiSO4·6H2O during the entire test period. Patch test reactivity to Na2PdCl4 is less variable over time compared to that for PdCl2 or NiSO4·6H2O. No clear covariation was identified between tests for palladium salts and NiSO4·6H2O. The variation in patch test reactivity found in this study could be due to seasonal changes.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
contact allergy, delayed hypersensitivity, equimolar, false-negative, metal salts, seasonal influence
in
European journal of dermatology : EJD
volume
28
issue
5
pages
9 pages
publisher
John Libbey Eurotext
external identifiers
  • scopus:85058551100
  • pmid:30530435
ISSN
1167-1122
DOI
10.1684/ejd.2018.3423
language
English
LU publication?
yes
id
d60de2b2-ce1e-4646-a7db-ce80789f535a
date added to LUP
2019-01-04 14:06:19
date last changed
2021-09-29 03:52:23
@article{d60de2b2-ce1e-4646-a7db-ce80789f535a,
  abstract     = {<p>Concomitant reactions to palladium chloride (PdCl2), sodium tetrachloropalladate (Na2PdCl4), and nickel hexahydrate sulphate (NiSO4·6H2O) are very common during patch testing and have mainly been explained by cross-sensitisation. Whether there is variation in reactivity to palladium or covariation to nickel and palladium is not known. The aim of this study was to investigate the variation in patch test reactivity to PdCl2 and Na2PdCl4 over time and compare this to variation in patch test reactivity to NiSO4·6H2O. Fifteen females known to be sensitised to nickel and palladium were patch tested four times with 12-week intervals using a dilution series of NiSO4·6H2O, PdCl2 or Na2PdCl4. Patch test reactivity to Na2PdCl4 was less variable compared to that for NiSO4·6H2O or PdCl2. All test salts showed higher patch test reactivity during wintertime. No significant correlation was observed between the variation in patch test reactivity to Na2PdCl4 and PdCl2 and the variation in patch test reactivity to NiSO4·6H2O during the entire test period. Patch test reactivity to Na2PdCl4 is less variable over time compared to that for PdCl2 or NiSO4·6H2O. No clear covariation was identified between tests for palladium salts and NiSO4·6H2O. The variation in patch test reactivity found in this study could be due to seasonal changes.</p>},
  author       = {Rosholm Comstedt, Lisbeth and Engfeldt, Malin and Svedman, Cecilia and Åkesson, Anna and Hindsén, Monica and Bruze, Magnus},
  issn         = {1167-1122},
  language     = {eng},
  number       = {5},
  pages        = {668--676},
  publisher    = {John Libbey Eurotext},
  series       = {European journal of dermatology : EJD},
  title        = {Variation and covariation in patch test reactivity to palladium and nickel salts},
  url          = {http://dx.doi.org/10.1684/ejd.2018.3423},
  doi          = {10.1684/ejd.2018.3423},
  volume       = {28},
  year         = {2018},
}