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Analysis of the interleukin-1 and interleukin-6 polymorphisms in patients with chronic periodontitis. A pilot study

Jansson, H; Lyssenko, Valeriya LU ; Gustavsson, A; Hamberg, K; Soderfeldt, B; Groop, Leif LU and Bratthall, G (2006) In Swedish Dental Journal1977-01-01+01:00 30(1). p.17-23
Abstract
The aim of this study was to analyse whether the interleukin-1 (IL-1) and IL-6 gene polymorphisms were associated with the susceptibility of chronic periodontitis. Genomic DNA was obtained from 20 patients with chronic periodontitis and 31 periodontally healthy subjects. All subjects were of North European heritage. The test subjects were kept in a maintenance program after periodontal treatment but yet showing signs of recurrent disease. Genotyping of the IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] polymorphisms was carried out using an allelic discrimination Assay-by-Design method on ABI PRISM 7900 Sequence Detection System. All genotypes were analyzed using the GeneMapper 2.0 software. A similar distribution... (More)
The aim of this study was to analyse whether the interleukin-1 (IL-1) and IL-6 gene polymorphisms were associated with the susceptibility of chronic periodontitis. Genomic DNA was obtained from 20 patients with chronic periodontitis and 31 periodontally healthy subjects. All subjects were of North European heritage. The test subjects were kept in a maintenance program after periodontal treatment but yet showing signs of recurrent disease. Genotyping of the IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] polymorphisms was carried out using an allelic discrimination Assay-by-Design method on ABI PRISM 7900 Sequence Detection System. All genotypes were analyzed using the GeneMapper 2.0 software. A similar distribution of Single Nucleotide Polymorphism (SNP) was seen in both groups. Analysis by logistic regression including gender, IL-1 alpha [+4845C>T], IL-1 beta [-3954C>T], IL-6 [-174G>C] genotypes, the composite IL-1 genotype, the combination of the composite IL-1 genotype and the IL-6 -174G>C genotype and adjusting for smoking did not result in any statistically significant difference. SNPs in IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] do not seem to increase the susceptibility to chronic periodontitis in this group of subjects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
interleukin-7, genotype, periodontal diseases, interleukin-6, polymorphism
in
Swedish Dental Journal1977-01-01+01:00
volume
30
issue
1
pages
17 - 23
publisher
Sveriges Tandläkarförbund
external identifiers
  • pmid:16708852
  • wos:000237318800003
  • scopus:33646374428
ISSN
0347-9994
language
English
LU publication?
yes
id
d64e2454-f7b7-497f-9aec-34c1e8c47712 (old id 410232)
date added to LUP
2007-10-05 14:03:24
date last changed
2019-05-28 02:19:46
@article{d64e2454-f7b7-497f-9aec-34c1e8c47712,
  abstract     = {The aim of this study was to analyse whether the interleukin-1 (IL-1) and IL-6 gene polymorphisms were associated with the susceptibility of chronic periodontitis. Genomic DNA was obtained from 20 patients with chronic periodontitis and 31 periodontally healthy subjects. All subjects were of North European heritage. The test subjects were kept in a maintenance program after periodontal treatment but yet showing signs of recurrent disease. Genotyping of the IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] polymorphisms was carried out using an allelic discrimination Assay-by-Design method on ABI PRISM 7900 Sequence Detection System. All genotypes were analyzed using the GeneMapper 2.0 software. A similar distribution of Single Nucleotide Polymorphism (SNP) was seen in both groups. Analysis by logistic regression including gender, IL-1 alpha [+4845C>T], IL-1 beta [-3954C>T], IL-6 [-174G>C] genotypes, the composite IL-1 genotype, the combination of the composite IL-1 genotype and the IL-6 -174G>C genotype and adjusting for smoking did not result in any statistically significant difference. SNPs in IL-1 alpha[+4845C>T], IL-1 beta [-3954C>T] and IL-6 [-174G>C] do not seem to increase the susceptibility to chronic periodontitis in this group of subjects.},
  author       = {Jansson, H and Lyssenko, Valeriya and Gustavsson, A and Hamberg, K and Soderfeldt, B and Groop, Leif and Bratthall, G},
  issn         = {0347-9994},
  keyword      = {interleukin-7,genotype,periodontal diseases,interleukin-6,polymorphism},
  language     = {eng},
  number       = {1},
  pages        = {17--23},
  publisher    = {Sveriges Tandläkarförbund},
  series       = {Swedish Dental Journal1977-01-01+01:00},
  title        = {Analysis of the interleukin-1 and interleukin-6 polymorphisms in patients with chronic periodontitis. A pilot study},
  volume       = {30},
  year         = {2006},
}