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Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Bentley, Amy R. ; V. Varga, Tibor LU ; Renström, Frida LU ; Franks, Paul LU ; Rotimi, Charles and Cupples, L. Adrienne (2019) In Nature Genetics 51(4). p.636-648
Abstract
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. © 2019, This is a... (More)
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. © 2019, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. (Less)
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type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
51
issue
4
pages
13 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85063914316
  • pmid:30926973
ISSN
1546-1718
DOI
10.1038/s41588-019-0378-y
language
English
LU publication?
yes
additional info
Export Date: 26 April 2019
id
d67f31c3-0f93-4bb0-9f4a-97453a80c48a
date added to LUP
2019-04-26 12:40:42
date last changed
2020-10-07 06:25:30
@article{d67f31c3-0f93-4bb0-9f4a-97453a80c48a,
  abstract     = {The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. © 2019, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.},
  author       = {Bentley, Amy R. and V. Varga, Tibor and Renström, Frida and Franks, Paul and Rotimi, Charles and Cupples, L. Adrienne},
  issn         = {1546-1718},
  language     = {eng},
  number       = {4},
  pages        = {636--648},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids},
  url          = {http://dx.doi.org/10.1038/s41588-019-0378-y},
  doi          = {10.1038/s41588-019-0378-y},
  volume       = {51},
  year         = {2019},
}