Modelling and optimisation of preparative chromatographic purification of europium.
(2012) In Journal of chromatography. A 1220. p.21-25- Abstract
- A model commonly used to describe the separation of biomolecules was used to simulate the harsh environment when eluting neodymium, samarium, europium and gadolinium with a hot acid. After calibration, the model was used to optimise the preparative separation of europium, as this is the most valuable of the four elements. A kinetic dispersive model with a Langmuir mobile phase modulator isotherm was used to describe the process. The equilibration constant, the stoichiometric coefficient and the column capacity for the components were calibrated. The model fitted the experimental observations well. Optimisation was achieved using a differential evolution method. As the two objective functions used in optimising the process, productivity and... (More)
- A model commonly used to describe the separation of biomolecules was used to simulate the harsh environment when eluting neodymium, samarium, europium and gadolinium with a hot acid. After calibration, the model was used to optimise the preparative separation of europium, as this is the most valuable of the four elements. A kinetic dispersive model with a Langmuir mobile phase modulator isotherm was used to describe the process. The equilibration constant, the stoichiometric coefficient and the column capacity for the components were calibrated. The model fitted the experimental observations well. Optimisation was achieved using a differential evolution method. As the two objective functions used in optimising the process, productivity and yield, are competing objectives, the result was not a single set point but a Pareto front. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2273724
- author
- Ojala, Frida LU ; Max-Hansen, Mark LU ; Kifle, Dejene ; Borg, Niklas LU and Nilsson, Bernt LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of chromatography. A
- volume
- 1220
- pages
- 21 - 25
- publisher
- Elsevier
- external identifiers
-
- wos:000299586000004
- pmid:22189296
- scopus:84855346585
- pmid:22189296
- ISSN
- 1873-3778
- DOI
- 10.1016/j.chroma.2011.11.028
- language
- English
- LU publication?
- yes
- id
- d68a7a61-ba2d-4738-9fe4-50f3eab0d7ec (old id 2273724)
- date added to LUP
- 2016-04-01 13:51:59
- date last changed
- 2023-10-01 07:55:24
@article{d68a7a61-ba2d-4738-9fe4-50f3eab0d7ec,
abstract = {{A model commonly used to describe the separation of biomolecules was used to simulate the harsh environment when eluting neodymium, samarium, europium and gadolinium with a hot acid. After calibration, the model was used to optimise the preparative separation of europium, as this is the most valuable of the four elements. A kinetic dispersive model with a Langmuir mobile phase modulator isotherm was used to describe the process. The equilibration constant, the stoichiometric coefficient and the column capacity for the components were calibrated. The model fitted the experimental observations well. Optimisation was achieved using a differential evolution method. As the two objective functions used in optimising the process, productivity and yield, are competing objectives, the result was not a single set point but a Pareto front.}},
author = {{Ojala, Frida and Max-Hansen, Mark and Kifle, Dejene and Borg, Niklas and Nilsson, Bernt}},
issn = {{1873-3778}},
language = {{eng}},
pages = {{21--25}},
publisher = {{Elsevier}},
series = {{Journal of chromatography. A}},
title = {{Modelling and optimisation of preparative chromatographic purification of europium.}},
url = {{http://dx.doi.org/10.1016/j.chroma.2011.11.028}},
doi = {{10.1016/j.chroma.2011.11.028}},
volume = {{1220}},
year = {{2012}},
}