A practical guide to microfabrication and patterning of hydrogels for biomimetic cell culture scaffolds
(2020) In Organs-on-a-Chip 2.- Abstract
- This review article describes microfabrication techniques to define chemical, mechanical and structural patterns in hydrogels and how these can be used to prepare in vivo like, i.e. biomimetic, cell culture scaffolds. Hydrogels are attractive materials for 3D cell cultures as they provide ideal culture conditions and they are becoming more prominently used. Single material gels without any modifications do however have their limitation in use and much can be gained by in improving the in vivo resemblance of simple hydrogel cell culture scaffolds. This review article discusses the most commonly used cross-linking strategies used for hydrogel-based culture scaffolds and gives a brief introduction to microfabrication methods that can be used... (More)
- This review article describes microfabrication techniques to define chemical, mechanical and structural patterns in hydrogels and how these can be used to prepare in vivo like, i.e. biomimetic, cell culture scaffolds. Hydrogels are attractive materials for 3D cell cultures as they provide ideal culture conditions and they are becoming more prominently used. Single material gels without any modifications do however have their limitation in use and much can be gained by in improving the in vivo resemblance of simple hydrogel cell culture scaffolds. This review article discusses the most commonly used cross-linking strategies used for hydrogel-based culture scaffolds and gives a brief introduction to microfabrication methods that can be used to define chemical, mechanical and structural patterns in hydrogels with micrometre resolution. The review article also describes a selection of literature references using these microfabrication techniques to prepare organ and disease models with controlled cell adhesion, proliferation and migration. It is intended to serve as an introduction to microfabrication of hydrogels and an inspiration for novel interdisciplinary research projects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/d6a959a0-9ea8-4cc7-8c7f-946ed50199bb
- author
- Tenje, Maria LU ; Cantoni, Federico ; Porras Hernández, Ana María ; Searle, Sean S. ; Johansson, Sofia LU ; Barbe, Laurent ; Antfolk, Maria LU and Pohlit, Hannah
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Organs-on-a-Chip
- volume
- 2
- article number
- 100003
- publisher
- Elsevier
- ISSN
- 2666-1020
- DOI
- 10.1016/j.ooc.2020.100003
- language
- English
- LU publication?
- no
- id
- d6a959a0-9ea8-4cc7-8c7f-946ed50199bb
- date added to LUP
- 2024-04-04 19:28:16
- date last changed
- 2024-04-05 13:06:05
@article{d6a959a0-9ea8-4cc7-8c7f-946ed50199bb, abstract = {{This review article describes microfabrication techniques to define chemical, mechanical and structural patterns in hydrogels and how these can be used to prepare in vivo like, i.e. biomimetic, cell culture scaffolds. Hydrogels are attractive materials for 3D cell cultures as they provide ideal culture conditions and they are becoming more prominently used. Single material gels without any modifications do however have their limitation in use and much can be gained by in improving the in vivo resemblance of simple hydrogel cell culture scaffolds. This review article discusses the most commonly used cross-linking strategies used for hydrogel-based culture scaffolds and gives a brief introduction to microfabrication methods that can be used to define chemical, mechanical and structural patterns in hydrogels with micrometre resolution. The review article also describes a selection of literature references using these microfabrication techniques to prepare organ and disease models with controlled cell adhesion, proliferation and migration. It is intended to serve as an introduction to microfabrication of hydrogels and an inspiration for novel interdisciplinary research projects.}}, author = {{Tenje, Maria and Cantoni, Federico and Porras Hernández, Ana María and Searle, Sean S. and Johansson, Sofia and Barbe, Laurent and Antfolk, Maria and Pohlit, Hannah}}, issn = {{2666-1020}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Organs-on-a-Chip}}, title = {{A practical guide to microfabrication and patterning of hydrogels for biomimetic cell culture scaffolds}}, url = {{http://dx.doi.org/10.1016/j.ooc.2020.100003}}, doi = {{10.1016/j.ooc.2020.100003}}, volume = {{2}}, year = {{2020}}, }