DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis
(2024) In Journal of Molecular Medicine 102(2). p.213-229- Abstract
Cancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora of physicochemical properties. Herein, we report that phenobarbital sodium can kill cancer cells by using the DSPE-PEG2000-methotrexate nanoparticle delivery system, which can target folate receptors that are usually overexpressed on a variety of cancer cells. The released phenobarbital then executes cancer cells by inducing... (More)
Cancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora of physicochemical properties. Herein, we report that phenobarbital sodium can kill cancer cells by using the DSPE-PEG2000-methotrexate nanoparticle delivery system, which can target folate receptors that are usually overexpressed on a variety of cancer cells. The released phenobarbital then executes cancer cells by inducing pyroptosis. Results from our animal model further indicate that the nanomedicine of nanoparticle-encapsulated phenobarbital sodium is a promising anticancer therapy.
(Less)
- author
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Folate receptors, Phenobarbital sodium, Pyroptosis
- in
- Journal of Molecular Medicine
- volume
- 102
- issue
- 2
- pages
- 17 pages
- publisher
- Springer
- external identifiers
-
- pmid:38047923
- scopus:85178491487
- ISSN
- 0946-2716
- DOI
- 10.1007/s00109-023-02403-7
- language
- English
- LU publication?
- yes
- id
- d6c33a93-c3fd-49ee-91ea-b05eabf5941f
- date added to LUP
- 2024-01-04 15:23:32
- date last changed
- 2025-05-03 23:12:33
@article{d6c33a93-c3fd-49ee-91ea-b05eabf5941f,
abstract = {{<p>Cancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora of physicochemical properties. Herein, we report that phenobarbital sodium can kill cancer cells by using the DSPE-PEG<sub>2000</sub>-methotrexate nanoparticle delivery system, which can target folate receptors that are usually overexpressed on a variety of cancer cells. The released phenobarbital then executes cancer cells by inducing pyroptosis. Results from our animal model further indicate that the nanomedicine of nanoparticle-encapsulated phenobarbital sodium is a promising anticancer therapy.</p>}},
author = {{Yin, Fengyue and Xu, Xiao and Qi, Julia and Guo, Mengyu and Wang, Yubo and Wang, Yun and Ye, Roumei and Lin, Qian and Yang, Daowei and Zhu, Xuan and Wang, Jinling}},
issn = {{0946-2716}},
keywords = {{Folate receptors; Phenobarbital sodium; Pyroptosis}},
language = {{eng}},
number = {{2}},
pages = {{213--229}},
publisher = {{Springer}},
series = {{Journal of Molecular Medicine}},
title = {{DSPE-PEG<sub>2000</sub>-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis}},
url = {{http://dx.doi.org/10.1007/s00109-023-02403-7}},
doi = {{10.1007/s00109-023-02403-7}},
volume = {{102}},
year = {{2024}},
}