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Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individuals

Groot, Colin ; Doré, Vincent ; Robertson, Joanne ; Burnham, Samantha C. ; Savage, Greg ; Ossenkoppele, Rik LU ; Rowe, Christopher C. and Villemagne, Victor L. (2021) In Neurobiology of Aging 97. p.41-48
Abstract

We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [18F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [18F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts... (More)

We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [18F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [18F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts (categorical). In addition, we assessed the effect of age and Aβ burden on Me-tau. Both continuous and categorical Me-tau was associated with worse cognitive performance across all tests and with higher lateral temporal and parietal [18F]flortaucipir signal. Furthermore, we observed a marginal association between Me-tau and age, whereas there was no association with Aβ burden. Our findings indicate that Me-tau in Aβ-negative cognitively normal individuals, which is likely age-related (i.e., primary age-related tauopathy), might not be as benign as commonly thought.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Mesial temporal lobe, PART, PET, Tau
in
Neurobiology of Aging
volume
97
pages
8 pages
publisher
Elsevier
external identifiers
  • pmid:33130455
  • scopus:85094187018
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2020.09.017
language
English
LU publication?
yes
id
d6d94626-512d-44fe-9b9b-64fe5ad8cc6a
date added to LUP
2020-11-04 11:05:49
date last changed
2024-06-12 22:54:12
@article{d6d94626-512d-44fe-9b9b-64fe5ad8cc6a,
  abstract     = {{<p>We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (&gt;60 years old). Me-tau was measured using [<sup>18</sup>F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [<sup>18</sup>F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts (categorical). In addition, we assessed the effect of age and Aβ burden on Me-tau. Both continuous and categorical Me-tau was associated with worse cognitive performance across all tests and with higher lateral temporal and parietal [<sup>18</sup>F]flortaucipir signal. Furthermore, we observed a marginal association between Me-tau and age, whereas there was no association with Aβ burden. Our findings indicate that Me-tau in Aβ-negative cognitively normal individuals, which is likely age-related (i.e., primary age-related tauopathy), might not be as benign as commonly thought.</p>}},
  author       = {{Groot, Colin and Doré, Vincent and Robertson, Joanne and Burnham, Samantha C. and Savage, Greg and Ossenkoppele, Rik and Rowe, Christopher C. and Villemagne, Victor L.}},
  issn         = {{0197-4580}},
  keywords     = {{Mesial temporal lobe; PART; PET; Tau}},
  language     = {{eng}},
  pages        = {{41--48}},
  publisher    = {{Elsevier}},
  series       = {{Neurobiology of Aging}},
  title        = {{Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individuals}},
  url          = {{http://dx.doi.org/10.1016/j.neurobiolaging.2020.09.017}},
  doi          = {{10.1016/j.neurobiolaging.2020.09.017}},
  volume       = {{97}},
  year         = {{2021}},
}