Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individuals
(2021) In Neurobiology of Aging 97. p.41-48- Abstract
We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [18F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [18F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts... (More)
We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [18F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [18F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts (categorical). In addition, we assessed the effect of age and Aβ burden on Me-tau. Both continuous and categorical Me-tau was associated with worse cognitive performance across all tests and with higher lateral temporal and parietal [18F]flortaucipir signal. Furthermore, we observed a marginal association between Me-tau and age, whereas there was no association with Aβ burden. Our findings indicate that Me-tau in Aβ-negative cognitively normal individuals, which is likely age-related (i.e., primary age-related tauopathy), might not be as benign as commonly thought.
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- author
- Groot, Colin ; Doré, Vincent ; Robertson, Joanne ; Burnham, Samantha C. ; Savage, Greg ; Ossenkoppele, Rik LU ; Rowe, Christopher C. and Villemagne, Victor L.
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Mesial temporal lobe, PART, PET, Tau
- in
- Neurobiology of Aging
- volume
- 97
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:33130455
- scopus:85094187018
- ISSN
- 0197-4580
- DOI
- 10.1016/j.neurobiolaging.2020.09.017
- language
- English
- LU publication?
- yes
- id
- d6d94626-512d-44fe-9b9b-64fe5ad8cc6a
- date added to LUP
- 2020-11-04 11:05:49
- date last changed
- 2024-09-19 08:08:51
@article{d6d94626-512d-44fe-9b9b-64fe5ad8cc6a, abstract = {{<p>We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [<sup>18</sup>F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [<sup>18</sup>F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts (categorical). In addition, we assessed the effect of age and Aβ burden on Me-tau. Both continuous and categorical Me-tau was associated with worse cognitive performance across all tests and with higher lateral temporal and parietal [<sup>18</sup>F]flortaucipir signal. Furthermore, we observed a marginal association between Me-tau and age, whereas there was no association with Aβ burden. Our findings indicate that Me-tau in Aβ-negative cognitively normal individuals, which is likely age-related (i.e., primary age-related tauopathy), might not be as benign as commonly thought.</p>}}, author = {{Groot, Colin and Doré, Vincent and Robertson, Joanne and Burnham, Samantha C. and Savage, Greg and Ossenkoppele, Rik and Rowe, Christopher C. and Villemagne, Victor L.}}, issn = {{0197-4580}}, keywords = {{Mesial temporal lobe; PART; PET; Tau}}, language = {{eng}}, pages = {{41--48}}, publisher = {{Elsevier}}, series = {{Neurobiology of Aging}}, title = {{Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individuals}}, url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2020.09.017}}, doi = {{10.1016/j.neurobiolaging.2020.09.017}}, volume = {{97}}, year = {{2021}}, }