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Prevalence of high-risk HPV in postmenopausal women with benign cervical cytology - A population-based cohort study

Asciutto, Katrin Christine LU ; Forslund, Ola LU and Borgfeldt, Christer LU (2018) In Anticancer research 38(7). p.4221-4228
Abstract

Aim: To compare the clinical performance of human papillomavirus (HPV) mRNA and DNA assays in postmenopausal women. Materials and Methods: A total of 5,925 postmenopausal women were tested with cytology and the Luminex HPV DNA assay. High risk-HPV-positive women with benign cytology underwent a complimentary HPV mRNA assay (APTIMA). Both assays and the cytological testing were repeated after 12 months. Results: A total of 334 women were found to be high-risk HPV-positive; 272 out of these women met the inclusion criteria. At follow-up, 25 (9.2%) out of the 272 included women had cytological abnormalities. HPV mRNA assay at follow-up had a sensitivity of 84% (95% confidence interval=63.9-95.4%) and a specificity of 60.2% (95% confidence... (More)

Aim: To compare the clinical performance of human papillomavirus (HPV) mRNA and DNA assays in postmenopausal women. Materials and Methods: A total of 5,925 postmenopausal women were tested with cytology and the Luminex HPV DNA assay. High risk-HPV-positive women with benign cytology underwent a complimentary HPV mRNA assay (APTIMA). Both assays and the cytological testing were repeated after 12 months. Results: A total of 334 women were found to be high-risk HPV-positive; 272 out of these women met the inclusion criteria. At follow-up, 25 (9.2%) out of the 272 included women had cytological abnormalities. HPV mRNA assay at follow-up had a sensitivity of 84% (95% confidence interval=63.9-95.4%) and a specificity of 60.2% (95% confidence interval=53.7-66.3%; p=0.0003) to detect these lesions. Corresponding values for the HPV DNA assay were 88% (95% confidence interval=68.8-97.4%) and 43.5% (95% confidence interval=37.2-49.4%). Conclusion: The HPV mRNA assay offers a comparable sensitivity but a higher specificity than the HPV DNA assay in detecting precancerous cervical lesions.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
High-risk HPV, HPV DNA, mRNA testing, Postmenopausal women
in
Anticancer research
volume
38
issue
7
pages
8 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85049798970
ISSN
0250-7005
DOI
10.21873/anticanres.12718
language
English
LU publication?
yes
id
d72a21cc-2bfb-47d6-90af-cb10f8cb20a0
date added to LUP
2018-09-07 12:33:29
date last changed
2019-04-23 04:38:07
@article{d72a21cc-2bfb-47d6-90af-cb10f8cb20a0,
  abstract     = {<p>Aim: To compare the clinical performance of human papillomavirus (HPV) mRNA and DNA assays in postmenopausal women. Materials and Methods: A total of 5,925 postmenopausal women were tested with cytology and the Luminex HPV DNA assay. High risk-HPV-positive women with benign cytology underwent a complimentary HPV mRNA assay (APTIMA). Both assays and the cytological testing were repeated after 12 months. Results: A total of 334 women were found to be high-risk HPV-positive; 272 out of these women met the inclusion criteria. At follow-up, 25 (9.2%) out of the 272 included women had cytological abnormalities. HPV mRNA assay at follow-up had a sensitivity of 84% (95% confidence interval=63.9-95.4%) and a specificity of 60.2% (95% confidence interval=53.7-66.3%; p=0.0003) to detect these lesions. Corresponding values for the HPV DNA assay were 88% (95% confidence interval=68.8-97.4%) and 43.5% (95% confidence interval=37.2-49.4%). Conclusion: The HPV mRNA assay offers a comparable sensitivity but a higher specificity than the HPV DNA assay in detecting precancerous cervical lesions.</p>},
  author       = {Asciutto, Katrin Christine and Forslund, Ola and Borgfeldt, Christer},
  issn         = {0250-7005},
  keyword      = {High-risk HPV,HPV DNA,mRNA testing,Postmenopausal women},
  language     = {eng},
  month        = {07},
  number       = {7},
  pages        = {4221--4228},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer research},
  title        = {Prevalence of high-risk HPV in postmenopausal women with benign cervical cytology - A population-based cohort study},
  url          = {http://dx.doi.org/10.21873/anticanres.12718},
  volume       = {38},
  year         = {2018},
}