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Pulmonary nocardiosis with brain abscess in a sensitized kidney transplant recipient with a history of repeated graft loss and HLA-antibody depletion treatment--a case report

Biglarnia, Ali-Reza LU orcid ; Wadström, Jonas ; Tufveson, Gunnar and Eriksson, Britt-Marie (2008) In Upsala Journal of Medical Sciences 113(1). p.6-111
Abstract

Nocardiosis is an opportunistic infection with unfavourable prognosis and is predominantly seen in immunocompromised patients. We here present a kidney transplant recipient with a history of two early graft losses who subsequently developed Human Leukocyte Antigen (HLA)-antibodies and underwent a desensitization treatment with plasmapheresis and monoclonal anti-CD20 antibody application. However, 3 months after a third HLA-identical kidney transplantation he developed Nocardiosis with pulmonary and asymptomatic brain manifestation. The present case report exemplifies this opportunistic infection and gives an overview of the literature.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoantibodies/immunology, Brain Abscess/complications, Cyclophosphamide/administration & dosage, Cyclosporine/administration & dosage, Graft Rejection, HLA Antigens/immunology, Humans, Immunosuppressive Agents/administration & dosage, Kidney Transplantation, Lung Diseases/complications, Male, Middle Aged, Nocardia Infections/complications, Treatment Outcome
in
Upsala Journal of Medical Sciences
volume
113
issue
1
pages
6 - 111
publisher
Upsala Medical Society
external identifiers
  • pmid:18521805
  • scopus:48949105090
ISSN
0300-9734
DOI
10.3109/2000-1967-212
language
English
LU publication?
no
id
d72a8199-69d1-4d9f-9632-685dfe10c1a3
date added to LUP
2025-12-17 14:23:13
date last changed
2025-12-19 02:25:41
@article{d72a8199-69d1-4d9f-9632-685dfe10c1a3,
  abstract     = {{<p>Nocardiosis is an opportunistic infection with unfavourable prognosis and is predominantly seen in immunocompromised patients. We here present a kidney transplant recipient with a history of two early graft losses who subsequently developed Human Leukocyte Antigen (HLA)-antibodies and underwent a desensitization treatment with plasmapheresis and monoclonal anti-CD20 antibody application. However, 3 months after a third HLA-identical kidney transplantation he developed Nocardiosis with pulmonary and asymptomatic brain manifestation. The present case report exemplifies this opportunistic infection and gives an overview of the literature.</p>}},
  author       = {{Biglarnia, Ali-Reza and Wadström, Jonas and Tufveson, Gunnar and Eriksson, Britt-Marie}},
  issn         = {{0300-9734}},
  keywords     = {{Autoantibodies/immunology; Brain Abscess/complications; Cyclophosphamide/administration & dosage; Cyclosporine/administration & dosage; Graft Rejection; HLA Antigens/immunology; Humans; Immunosuppressive Agents/administration & dosage; Kidney Transplantation; Lung Diseases/complications; Male; Middle Aged; Nocardia Infections/complications; Treatment Outcome}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{6--111}},
  publisher    = {{Upsala Medical Society}},
  series       = {{Upsala Journal of Medical Sciences}},
  title        = {{Pulmonary nocardiosis with brain abscess in a sensitized kidney transplant recipient with a history of repeated graft loss and HLA-antibody depletion treatment--a case report}},
  url          = {{http://dx.doi.org/10.3109/2000-1967-212}},
  doi          = {{10.3109/2000-1967-212}},
  volume       = {{113}},
  year         = {{2008}},
}