Advanced

Caffeine has no effect on eyeblink conditioning in mice

Rasmussen, Anders LU ; Ijpelaar, Anna C H G; De Zeeuw, Chris I. and Boele, Henk-Jan LU (2017) In Behavioural Brain Research
Abstract

Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine... (More)

Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine neither improves nor worsens performance on eyeblink conditioning.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
epub
keywords
Journal Article
in
Behavioural Brain Research
publisher
Elsevier
external identifiers
  • scopus:85029513052
ISSN
0166-4328
DOI
10.1016/j.bbr.2017.09.013
language
English
LU publication?
no
id
d72bd96a-12ec-4b19-bc62-99b29aec258d
date added to LUP
2017-09-27 10:40:28
date last changed
2018-11-21 21:34:48
@article{d72bd96a-12ec-4b19-bc62-99b29aec258d,
  abstract     = {<p>Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine neither improves nor worsens performance on eyeblink conditioning.</p>},
  author       = {Rasmussen, Anders and Ijpelaar, Anna C H G and De Zeeuw, Chris I. and Boele, Henk-Jan},
  issn         = {0166-4328},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {09},
  publisher    = {Elsevier},
  series       = {Behavioural Brain Research},
  title        = {Caffeine has no effect on eyeblink conditioning in mice},
  url          = {http://dx.doi.org/10.1016/j.bbr.2017.09.013},
  year         = {2017},
}