Caffeine has no effect on eyeblink conditioning in mice
(2018) In Behavioural Brain Research 337. p.252-255- Abstract
Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine... (More)
Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine neither improves nor worsens performance on eyeblink conditioning.
(Less)
- author
- Rasmussen, Anders LU ; Ijpelaar, Anna C H G ; De Zeeuw, Chris I. and Boele, Henk-Jan LU
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- keywords
- Journal Article
- in
- Behavioural Brain Research
- volume
- 337
- pages
- 252 - 255
- publisher
- Elsevier
- external identifiers
-
- scopus:85029513052
- pmid:28893553
- ISSN
- 0166-4328
- DOI
- 10.1016/j.bbr.2017.09.013
- language
- English
- LU publication?
- no
- id
- d72bd96a-12ec-4b19-bc62-99b29aec258d
- date added to LUP
- 2017-09-27 10:40:28
- date last changed
- 2024-07-08 01:31:08
@article{d72bd96a-12ec-4b19-bc62-99b29aec258d, abstract = {{<p>Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine neither improves nor worsens performance on eyeblink conditioning.</p>}}, author = {{Rasmussen, Anders and Ijpelaar, Anna C H G and De Zeeuw, Chris I. and Boele, Henk-Jan}}, issn = {{0166-4328}}, keywords = {{Journal Article}}, language = {{eng}}, pages = {{252--255}}, publisher = {{Elsevier}}, series = {{Behavioural Brain Research}}, title = {{Caffeine has no effect on eyeblink conditioning in mice}}, url = {{http://dx.doi.org/10.1016/j.bbr.2017.09.013}}, doi = {{10.1016/j.bbr.2017.09.013}}, volume = {{337}}, year = {{2018}}, }