Lower Frequency of Comorbidities Prior to Onset of Giant Cell Arteritis : A Population-Based Study
(2023) In The Journal of rheumatology 50(4). p.526-531- Abstract
OBJECTIVE: To assess the frequency of comorbidities and metabolic risk factors at and prior to giant cell arteritis (GCA) diagnosis. METHODS: This is a retrospective case control study of patients with incident GCA between January 1, 2000, and December 31, 2019, in Olmsted County, Minnesota. Two age- and sex-matched controls were identified, and each assigned an index date corresponding to an incidence date of GCA. Medical records were manually abstracted for comorbidities and laboratory data at incidence date, 5 years, and 10 years prior to incidence date. Twenty-five chronic conditions using International Classification of Diseases, 9th revision, diagnosis codes were also studied at incidence date and 5 years prior to incidence date.... (More)
OBJECTIVE: To assess the frequency of comorbidities and metabolic risk factors at and prior to giant cell arteritis (GCA) diagnosis. METHODS: This is a retrospective case control study of patients with incident GCA between January 1, 2000, and December 31, 2019, in Olmsted County, Minnesota. Two age- and sex-matched controls were identified, and each assigned an index date corresponding to an incidence date of GCA. Medical records were manually abstracted for comorbidities and laboratory data at incidence date, 5 years, and 10 years prior to incidence date. Twenty-five chronic conditions using International Classification of Diseases, 9th revision, diagnosis codes were also studied at incidence date and 5 years prior to incidence date. RESULTS: One hundred and twenty-nine patients with GCA (74% female) and 253 controls were identified. At incidence date, the prevalence of diabetes mellitus (DM) was lower among patients with GCA (5% vs 17%; P = 0.001). At 5 years prior to incidence date, patients were less likely to have DM (2% vs 13%; P < 0.001) and hypertension (27% vs 45%; P = 0.002) and had a lower mean number (SD) of comorbidities (0.7 [1.0] vs 1.3 [1.4]; P < 0.001) compared to controls. Moreover, patients had significantly lower median fasting blood glucose (FBG; 96 mg/dL vs 104 mg/dL; P < 0.001) and BMI (25.8 vs 27.7; P = 0.02) compared to controls. Multivariable logistic regression analysis revealed negative associations for FBG with GCA at 5 and 10 years prior to diagnosis/index date. CONCLUSION: DM prevalence and median FBG and BMI were lower in patients with GCA up to 5 years prior to diagnosis, suggesting that metabolic factors influence the risk of GCA.
(Less)
- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- comorbidity, diabetes mellitus, epidemiology, giant cell arteritis, incidence, vasculitis
- in
- The Journal of rheumatology
- volume
- 50
- issue
- 4
- pages
- 6 pages
- publisher
- Journal of Rheumatology Publishing Company Limited
- external identifiers
-
- pmid:36521923
- scopus:85151574480
- ISSN
- 0315-162X
- DOI
- 10.3899/jrheum.220610
- language
- English
- LU publication?
- yes
- id
- d72f0c5c-db7d-4877-9c22-df48bd328d86
- date added to LUP
- 2023-05-22 12:30:56
- date last changed
- 2024-06-15 03:06:36
@article{d72f0c5c-db7d-4877-9c22-df48bd328d86,
abstract = {{<p>OBJECTIVE: To assess the frequency of comorbidities and metabolic risk factors at and prior to giant cell arteritis (GCA) diagnosis. METHODS: This is a retrospective case control study of patients with incident GCA between January 1, 2000, and December 31, 2019, in Olmsted County, Minnesota. Two age- and sex-matched controls were identified, and each assigned an index date corresponding to an incidence date of GCA. Medical records were manually abstracted for comorbidities and laboratory data at incidence date, 5 years, and 10 years prior to incidence date. Twenty-five chronic conditions using International Classification of Diseases, 9th revision, diagnosis codes were also studied at incidence date and 5 years prior to incidence date. RESULTS: One hundred and twenty-nine patients with GCA (74% female) and 253 controls were identified. At incidence date, the prevalence of diabetes mellitus (DM) was lower among patients with GCA (5% vs 17%; P = 0.001). At 5 years prior to incidence date, patients were less likely to have DM (2% vs 13%; P < 0.001) and hypertension (27% vs 45%; P = 0.002) and had a lower mean number (SD) of comorbidities (0.7 [1.0] vs 1.3 [1.4]; P < 0.001) compared to controls. Moreover, patients had significantly lower median fasting blood glucose (FBG; 96 mg/dL vs 104 mg/dL; P < 0.001) and BMI (25.8 vs 27.7; P = 0.02) compared to controls. Multivariable logistic regression analysis revealed negative associations for FBG with GCA at 5 and 10 years prior to diagnosis/index date. CONCLUSION: DM prevalence and median FBG and BMI were lower in patients with GCA up to 5 years prior to diagnosis, suggesting that metabolic factors influence the risk of GCA.</p>}},
author = {{Elfishawi, Mohanad and Rakholiya, Jigisha and Gunderson, Tina M. and Achenbach, Sara J. and Crowson, Cynthia S. and Matteson, Eric L. and Turesson, Carl and Wadström, Karin and Weyand, Cornelia and Koster, Matthew J. and Warrington, Kenneth J.}},
issn = {{0315-162X}},
keywords = {{comorbidity; diabetes mellitus; epidemiology; giant cell arteritis; incidence; vasculitis}},
language = {{eng}},
number = {{4}},
pages = {{526--531}},
publisher = {{Journal of Rheumatology Publishing Company Limited}},
series = {{The Journal of rheumatology}},
title = {{Lower Frequency of Comorbidities Prior to Onset of Giant Cell Arteritis : A Population-Based Study}},
url = {{http://dx.doi.org/10.3899/jrheum.220610}},
doi = {{10.3899/jrheum.220610}},
volume = {{50}},
year = {{2023}},
}