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Xolair Is Effective in Allergics with a Low Serum IgE Level.

Ankerst, Jaro LU orcid ; Nopp, A ; Johansson, S G O ; Adédoyin, J and Oman, H (2010) In International Archives of Allergy and Immunology 152(1). p.71-74
Abstract
Background: Two atopic patients suffering from severe allergy difficult to handle by conventional medication were given Xolair despite an IgE level <30 kU/l. Methods: Increasing dosages were given and monitored by clinical evaluation and CD-sens to clinically relevant allergens. The patients' IgE antibody fractions were 11-14%. Results: Xolair dosages extrapolated from a recommended dose for IgE of 30-75 kU/l were adapted to the patients' IgE body pool but had very little effect. The double dose resulted in some clinical improvement and a decrease in CD-sens. However, not until the dose was doubled again did the patients become symptom free, although 1 patient needed some additional drugs but no oral steroids. CD-sens turned negative to... (More)
Background: Two atopic patients suffering from severe allergy difficult to handle by conventional medication were given Xolair despite an IgE level <30 kU/l. Methods: Increasing dosages were given and monitored by clinical evaluation and CD-sens to clinically relevant allergens. The patients' IgE antibody fractions were 11-14%. Results: Xolair dosages extrapolated from a recommended dose for IgE of 30-75 kU/l were adapted to the patients' IgE body pool but had very little effect. The double dose resulted in some clinical improvement and a decrease in CD-sens. However, not until the dose was doubled again did the patients become symptom free, although 1 patient needed some additional drugs but no oral steroids. CD-sens turned negative to 5 of the 7 tested allergens. Conclusions: Xolair is most useful also in atopics with an IgE level <30 kU/l. The dose must be adjusted to the size of the IgE antibody fraction adding all non-cross-reacting, clinically relevant specificities. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Archives of Allergy and Immunology
volume
152
issue
1
pages
71 - 74
publisher
Karger
external identifiers
  • wos:000275350800009
  • pmid:19940508
  • scopus:70450173212
  • pmid:19940508
ISSN
1423-0097
DOI
10.1159/000260086
language
English
LU publication?
yes
id
d7306ee8-8f65-485c-ac73-95a5182e4b7e (old id 1511534)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19940508?dopt=Abstract
date added to LUP
2016-04-04 07:17:27
date last changed
2025-10-14 10:55:04
@article{d7306ee8-8f65-485c-ac73-95a5182e4b7e,
  abstract     = {{Background: Two atopic patients suffering from severe allergy difficult to handle by conventional medication were given Xolair despite an IgE level &lt;30 kU/l. Methods: Increasing dosages were given and monitored by clinical evaluation and CD-sens to clinically relevant allergens. The patients' IgE antibody fractions were 11-14%. Results: Xolair dosages extrapolated from a recommended dose for IgE of 30-75 kU/l were adapted to the patients' IgE body pool but had very little effect. The double dose resulted in some clinical improvement and a decrease in CD-sens. However, not until the dose was doubled again did the patients become symptom free, although 1 patient needed some additional drugs but no oral steroids. CD-sens turned negative to 5 of the 7 tested allergens. Conclusions: Xolair is most useful also in atopics with an IgE level &lt;30 kU/l. The dose must be adjusted to the size of the IgE antibody fraction adding all non-cross-reacting, clinically relevant specificities.}},
  author       = {{Ankerst, Jaro and Nopp, A and Johansson, S G O and Adédoyin, J and Oman, H}},
  issn         = {{1423-0097}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{71--74}},
  publisher    = {{Karger}},
  series       = {{International Archives of Allergy and Immunology}},
  title        = {{Xolair Is Effective in Allergics with a Low Serum IgE Level.}},
  url          = {{http://dx.doi.org/10.1159/000260086}},
  doi          = {{10.1159/000260086}},
  volume       = {{152}},
  year         = {{2010}},
}