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Serum and nasal lavage fluid eosinophil-derived neurotoxin levels and their determinants in adults

Özuygur Ermis, Saliha Selin ; Malmhäll, Carina ; Borres, Magnus P. ; Movérare, Robert ; Lisik, Daniil ; Abohalaka, Reshed ; Ercan, Selin ; Schmeisser, Susanne ; Basna, Rani LU orcid and Mincheva, Roxana , et al. (2025) In Journal of Allergy and Clinical Immunology: Global 4(3). p.1-14
Abstract

Background: Eosinophil-derived neurotoxin (EDN), an eosinophil granule protein, is a candidate biomarker in asthma to reflect eosinophilic activation. Objective: We sought to characterize the distribution of serum and nasal lavage fluid (NLF) EDN levels in different adult population subgroups and assess the determinants of high EDN levels. Methods: Serum and NLF samples were collected from a population-based adult cohort study, the West Sweden Asthma Study. In total, serum EDN was measured in 2939 subjects and NLF EDN in 878 subjects, both using ImmunoCAP (Phadia AB/Thermo Fisher Scientific, Uppsala, Sweden). High EDN levels were defined as values higher than the third quartile, derived from randomly selected general adult population.... (More)

Background: Eosinophil-derived neurotoxin (EDN), an eosinophil granule protein, is a candidate biomarker in asthma to reflect eosinophilic activation. Objective: We sought to characterize the distribution of serum and nasal lavage fluid (NLF) EDN levels in different adult population subgroups and assess the determinants of high EDN levels. Methods: Serum and NLF samples were collected from a population-based adult cohort study, the West Sweden Asthma Study. In total, serum EDN was measured in 2939 subjects and NLF EDN in 878 subjects, both using ImmunoCAP (Phadia AB/Thermo Fisher Scientific, Uppsala, Sweden). High EDN levels were defined as values higher than the third quartile, derived from randomly selected general adult population. Background and clinical determinants of high EDN levels were assessed in serum and NLF samples. Results: Males had higher EDN levels than females, regardless of presence of asthma or atopy. EDN levels differed by obesity and atopy, but not by age, in the random adult population. Obesity was associated with high serum EDN levels in females (adjusted odds ratio [AOR], 1.81; 95% CI, 1.08-3.04) but not in males (AOR, 1.20; 95% CI, 0.63-2.29) in the random adult population. Subjects with current asthma were more likely to have higher serum EDN levels (AOR, 1.83; 95% CI, 1.55-2.17) than those without current asthma, but not higher NLF EDN levels. Conclusions: Adults with current asthma were more likely to have higher serum, but not NLF, EDN levels than those without asthma. Although serum EDN could be a promising marker in asthma, background determinants—such as sex, obesity, and atopy—should be considered when interpreting EDN levels.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adult, allergy, Asthma, biomarker, EDN, eosinophil, eosinophil-derived neurotoxin, phenotype
in
Journal of Allergy and Clinical Immunology: Global
volume
4
issue
3
article number
100510
pages
1 - 14
external identifiers
  • pmid:40677614
  • scopus:105009341706
DOI
10.1016/j.jacig.2025.100510
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Authors
id
d73f8332-e4f6-46ff-81ea-f5d0ce5bc2cd
date added to LUP
2025-08-21 09:50:05
date last changed
2025-08-22 03:00:02
@article{d73f8332-e4f6-46ff-81ea-f5d0ce5bc2cd,
  abstract     = {{<p>Background: Eosinophil-derived neurotoxin (EDN), an eosinophil granule protein, is a candidate biomarker in asthma to reflect eosinophilic activation. Objective: We sought to characterize the distribution of serum and nasal lavage fluid (NLF) EDN levels in different adult population subgroups and assess the determinants of high EDN levels. Methods: Serum and NLF samples were collected from a population-based adult cohort study, the West Sweden Asthma Study. In total, serum EDN was measured in 2939 subjects and NLF EDN in 878 subjects, both using ImmunoCAP (Phadia AB/Thermo Fisher Scientific, Uppsala, Sweden). High EDN levels were defined as values higher than the third quartile, derived from randomly selected general adult population. Background and clinical determinants of high EDN levels were assessed in serum and NLF samples. Results: Males had higher EDN levels than females, regardless of presence of asthma or atopy. EDN levels differed by obesity and atopy, but not by age, in the random adult population. Obesity was associated with high serum EDN levels in females (adjusted odds ratio [AOR], 1.81; 95% CI, 1.08-3.04) but not in males (AOR, 1.20; 95% CI, 0.63-2.29) in the random adult population. Subjects with current asthma were more likely to have higher serum EDN levels (AOR, 1.83; 95% CI, 1.55-2.17) than those without current asthma, but not higher NLF EDN levels. Conclusions: Adults with current asthma were more likely to have higher serum, but not NLF, EDN levels than those without asthma. Although serum EDN could be a promising marker in asthma, background determinants—such as sex, obesity, and atopy—should be considered when interpreting EDN levels.</p>}},
  author       = {{Özuygur Ermis, Saliha Selin and Malmhäll, Carina and Borres, Magnus P. and Movérare, Robert and Lisik, Daniil and Abohalaka, Reshed and Ercan, Selin and Schmeisser, Susanne and Basna, Rani and Mincheva, Roxana and Wennergren, Göran and Lötvall, Jan and Ekerljung, Linda and Rådinger, Madeleine and Kankaanranta, Hannu and Nwaru, Bright I.}},
  keywords     = {{adult; allergy; Asthma; biomarker; EDN; eosinophil; eosinophil-derived neurotoxin; phenotype}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1--14}},
  series       = {{Journal of Allergy and Clinical Immunology: Global}},
  title        = {{Serum and nasal lavage fluid eosinophil-derived neurotoxin levels and their determinants in adults}},
  url          = {{http://dx.doi.org/10.1016/j.jacig.2025.100510}},
  doi          = {{10.1016/j.jacig.2025.100510}},
  volume       = {{4}},
  year         = {{2025}},
}