Prediction of local fixed charge density loss in cartilage following ACL injury and reconstruction : A computational proof-of-concept study with MRI follow-up
(2021) In Journal of Orthopaedic Research 39(5). p.1064-1081- Abstract
The purpose of this proof-of-concept study was to develop three-dimensional patient-specific mechanobiological knee joint models to simulate alterations in the fixed charged density (FCD) around cartilage lesions during the stance phase of the walking gait. Two patients with anterior cruciate ligament (ACL) reconstructed knees were imaged at 1 and 3 years after surgery. The magnetic resonance imaging (MRI) data were used for segmenting the knee geometries, including the cartilage lesions. Based on these geometries, finite element (FE) models were developed. The gait of the patients was obtained using a motion capture system. Musculoskeletal modeling was utilized to calculate knee joint contact and lower extremity muscle forces for the... (More)
The purpose of this proof-of-concept study was to develop three-dimensional patient-specific mechanobiological knee joint models to simulate alterations in the fixed charged density (FCD) around cartilage lesions during the stance phase of the walking gait. Two patients with anterior cruciate ligament (ACL) reconstructed knees were imaged at 1 and 3 years after surgery. The magnetic resonance imaging (MRI) data were used for segmenting the knee geometries, including the cartilage lesions. Based on these geometries, finite element (FE) models were developed. The gait of the patients was obtained using a motion capture system. Musculoskeletal modeling was utilized to calculate knee joint contact and lower extremity muscle forces for the FE models. Finally, a cartilage adaptation algorithm was implemented in both FE models. In the algorithm, it was assumed that excessive maximum shear and deviatoric strains (calculated as the combination of principal strains), and fluid velocity, are responsible for the FCD loss. Changes in the longitudinal T1ρ and T2 relaxation times were postulated to be related to changes in the cartilage composition and were compared with the numerical predictions. In patient 1 model, both the excessive fluid velocity and strain caused the FCD loss primarily near the cartilage lesion. T1ρ and T2 relaxation times increased during the follow-up in the same location. In contrast, in patient 2 model, only the excessive fluid velocity led to a slight FCD loss near the lesion, where MRI parameters did not show evidence of alterations. Significance: This novel proof-of-concept study suggests mechanisms through which a local FCD loss might occur near cartilage lesions. In order to obtain statistical evidence for these findings, the method should be investigated with a larger cohort of subjects.
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- author
- Orozco, Gustavo A LU ; Bolcos, Paul ; Mohammadi, Ali ; Tanaka, Matthew S ; Yang, Mingrui ; Link, Thomas M ; Ma, Benjamin ; Li, Xiaojuan ; Tanska, Petri and Korhonen, Rami K
- publishing date
- 2021-05
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Anterior Cruciate Ligament Injuries/diagnostic imaging, Anterior Cruciate Ligament Reconstruction/adverse effects, Biomechanical Phenomena, Cartilage, Articular/diagnostic imaging, Finite Element Analysis, Follow-Up Studies, Humans, Knee Joint/diagnostic imaging, Magnetic Resonance Imaging/methods
- in
- Journal of Orthopaedic Research
- volume
- 39
- issue
- 5
- pages
- 18 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:32639603
- scopus:85088143108
- ISSN
- 1554-527X
- DOI
- 10.1002/jor.24797
- language
- English
- LU publication?
- no
- additional info
- © 2020 The Authors. Journal of Orthopaedic Research ® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.
- id
- d7421529-a84e-4b07-93bf-1d701c99ae68
- date added to LUP
- 2022-04-25 08:27:02
- date last changed
- 2024-06-28 16:02:23
@article{d7421529-a84e-4b07-93bf-1d701c99ae68,
abstract = {{<p>The purpose of this proof-of-concept study was to develop three-dimensional patient-specific mechanobiological knee joint models to simulate alterations in the fixed charged density (FCD) around cartilage lesions during the stance phase of the walking gait. Two patients with anterior cruciate ligament (ACL) reconstructed knees were imaged at 1 and 3 years after surgery. The magnetic resonance imaging (MRI) data were used for segmenting the knee geometries, including the cartilage lesions. Based on these geometries, finite element (FE) models were developed. The gait of the patients was obtained using a motion capture system. Musculoskeletal modeling was utilized to calculate knee joint contact and lower extremity muscle forces for the FE models. Finally, a cartilage adaptation algorithm was implemented in both FE models. In the algorithm, it was assumed that excessive maximum shear and deviatoric strains (calculated as the combination of principal strains), and fluid velocity, are responsible for the FCD loss. Changes in the longitudinal T1ρ and T2 relaxation times were postulated to be related to changes in the cartilage composition and were compared with the numerical predictions. In patient 1 model, both the excessive fluid velocity and strain caused the FCD loss primarily near the cartilage lesion. T1ρ and T2 relaxation times increased during the follow-up in the same location. In contrast, in patient 2 model, only the excessive fluid velocity led to a slight FCD loss near the lesion, where MRI parameters did not show evidence of alterations. Significance: This novel proof-of-concept study suggests mechanisms through which a local FCD loss might occur near cartilage lesions. In order to obtain statistical evidence for these findings, the method should be investigated with a larger cohort of subjects.</p>}},
author = {{Orozco, Gustavo A and Bolcos, Paul and Mohammadi, Ali and Tanaka, Matthew S and Yang, Mingrui and Link, Thomas M and Ma, Benjamin and Li, Xiaojuan and Tanska, Petri and Korhonen, Rami K}},
issn = {{1554-527X}},
keywords = {{Adult; Anterior Cruciate Ligament Injuries/diagnostic imaging; Anterior Cruciate Ligament Reconstruction/adverse effects; Biomechanical Phenomena; Cartilage, Articular/diagnostic imaging; Finite Element Analysis; Follow-Up Studies; Humans; Knee Joint/diagnostic imaging; Magnetic Resonance Imaging/methods}},
language = {{eng}},
number = {{5}},
pages = {{1064--1081}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Orthopaedic Research}},
title = {{Prediction of local fixed charge density loss in cartilage following ACL injury and reconstruction : A computational proof-of-concept study with MRI follow-up}},
url = {{http://dx.doi.org/10.1002/jor.24797}},
doi = {{10.1002/jor.24797}},
volume = {{39}},
year = {{2021}},
}