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α-Synuclein: The Long Distance Runner.

George, Sonia LU ; Rey, Nolwen LU ; Reichenbach, Nicole LU ; Steiner, Jennifer LU and Brundin, Patrik LU (2013) In Brain Pathology 23(3). p.350-357
Abstract
Parkinson's disease is characterized by α-synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α-synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α-synuclein can transfer from cell to cell. In this review, we highlight the involvement of α-synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of α-synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Brain Pathology
volume
23
issue
3
pages
350 - 357
publisher
Wiley-Blackwell
external identifiers
  • wos:000317865800014
  • pmid:23587141
  • scopus:84876240395
ISSN
1750-3639
DOI
10.1111/bpa.12046
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
d7471c28-be24-42f2-8759-ec5970bf5c25 (old id 3733777)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23587141?dopt=Abstract
date added to LUP
2016-04-01 10:35:08
date last changed
2022-04-27 23:26:32
@article{d7471c28-be24-42f2-8759-ec5970bf5c25,
  abstract     = {{Parkinson's disease is characterized by α-synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α-synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α-synuclein can transfer from cell to cell. In this review, we highlight the involvement of α-synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of α-synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons.}},
  author       = {{George, Sonia and Rey, Nolwen and Reichenbach, Nicole and Steiner, Jennifer and Brundin, Patrik}},
  issn         = {{1750-3639}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{350--357}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Brain Pathology}},
  title        = {{α-Synuclein: The Long Distance Runner.}},
  url          = {{http://dx.doi.org/10.1111/bpa.12046}},
  doi          = {{10.1111/bpa.12046}},
  volume       = {{23}},
  year         = {{2013}},
}