α-Synuclein: The Long Distance Runner.
(2013) In Brain Pathology 23(3). p.350-357- Abstract
- Parkinson's disease is characterized by α-synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α-synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α-synuclein can transfer from cell to cell. In this review, we highlight the involvement of α-synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of α-synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3733777
- author
- George, Sonia LU ; Rey, Nolwen LU ; Reichenbach, Nicole LU ; Steiner, Jennifer LU and Brundin, Patrik LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Brain Pathology
- volume
- 23
- issue
- 3
- pages
- 350 - 357
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000317865800014
- pmid:23587141
- scopus:84876240395
- ISSN
- 1750-3639
- DOI
- 10.1111/bpa.12046
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- d7471c28-be24-42f2-8759-ec5970bf5c25 (old id 3733777)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23587141?dopt=Abstract
- date added to LUP
- 2016-04-01 10:35:08
- date last changed
- 2022-04-27 23:26:32
@article{d7471c28-be24-42f2-8759-ec5970bf5c25, abstract = {{Parkinson's disease is characterized by α-synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α-synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α-synuclein can transfer from cell to cell. In this review, we highlight the involvement of α-synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of α-synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons.}}, author = {{George, Sonia and Rey, Nolwen and Reichenbach, Nicole and Steiner, Jennifer and Brundin, Patrik}}, issn = {{1750-3639}}, language = {{eng}}, number = {{3}}, pages = {{350--357}}, publisher = {{Wiley-Blackwell}}, series = {{Brain Pathology}}, title = {{α-Synuclein: The Long Distance Runner.}}, url = {{http://dx.doi.org/10.1111/bpa.12046}}, doi = {{10.1111/bpa.12046}}, volume = {{23}}, year = {{2013}}, }