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Postprandial increase in energy expenditure correlates with body weight reduction in patients with type 2 diabetes receiving diet therapy

Sanoyama, Daisuke; Nagao, Mototsugu LU ; Asai, Akira; Nakamura, Yuko; Sato, Kazumi; Nakajima, Yasushi; Oikawa, Shinichi and Sugihara, Hitoshi (2017) In Journal of Atherosclerosis and Thrombosis 24(4). p.422-429
Abstract

Aim: The clinical significance of energy expenditure (EE) in the treatment of type 2 diabetes has not been fully elucidated. Here we analyzed the relationships between EE and clinical measurements in patients with type 2 diabetes receiving diet therapy. Methods: A total of 100 patients (34 women and 66 men) with type 2 diabetes admitted to our hospital for glycemic control were enrolled. The participants received an energy-restricted diet during their hospitalization (median, 15 days). EE was measured in the fasted (FEE) and postprandial (PPEE) states using indirect calorimetry. The postprandial increment of EE (ΔEE) was calculated from the FEE and PPEE (ΔEE=PPEE– FEE). Results: FEE, PPEE, and ΔEE were 0.997±0.203, 1.104±0.213, and... (More)

Aim: The clinical significance of energy expenditure (EE) in the treatment of type 2 diabetes has not been fully elucidated. Here we analyzed the relationships between EE and clinical measurements in patients with type 2 diabetes receiving diet therapy. Methods: A total of 100 patients (34 women and 66 men) with type 2 diabetes admitted to our hospital for glycemic control were enrolled. The participants received an energy-restricted diet during their hospitalization (median, 15 days). EE was measured in the fasted (FEE) and postprandial (PPEE) states using indirect calorimetry. The postprandial increment of EE (ΔEE) was calculated from the FEE and PPEE (ΔEE=PPEE– FEE). Results: FEE, PPEE, and ΔEE were 0.997±0.203, 1.104±0.213, and 0.107±0.134 kcal/min, respectively. Body weight decreased from 68.7±16.6 to 66.8±16.0 kg (p<0.0001) during hospitalization. FEE and PPEE showed positive correlations with height, body weight, body mass index, and abdominal circumference at admission, but ΔEE was not correlated with these anthropometric measurements. On the other hand, ΔEE was inversely correlated with the body weight change. The association between ΔEE and the body weight change was independent of age, sex, and HbA1c. Conclusions: Postprandial increase in energy expenditure may be a determinant of individual differences in weight reduction in patients with type 2 diabetes on diet therapy. As a simple surrogate for diet-induced thermogenesis, ΔEE may serve as a useful predictive marker for the efficacy of diet therapy.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Diet therapy, Energy expenditure, Type 2 diabetes mellitus
in
Journal of Atherosclerosis and Thrombosis
volume
24
issue
4
pages
422 - 429
publisher
Japan Atherosclerosis Society
external identifiers
  • scopus:85016960135
ISSN
1340-3478
DOI
10.5551/jat.35303
language
English
LU publication?
no
id
d76cc3dc-8834-44b2-bfe9-56b693ecbb81
date added to LUP
2017-08-23 19:56:53
date last changed
2017-08-24 15:08:25
@article{d76cc3dc-8834-44b2-bfe9-56b693ecbb81,
  abstract     = {<p>Aim: The clinical significance of energy expenditure (EE) in the treatment of type 2 diabetes has not been fully elucidated. Here we analyzed the relationships between EE and clinical measurements in patients with type 2 diabetes receiving diet therapy. Methods: A total of 100 patients (34 women and 66 men) with type 2 diabetes admitted to our hospital for glycemic control were enrolled. The participants received an energy-restricted diet during their hospitalization (median, 15 days). EE was measured in the fasted (FEE) and postprandial (PPEE) states using indirect calorimetry. The postprandial increment of EE (ΔEE) was calculated from the FEE and PPEE (ΔEE=PPEE– FEE). Results: FEE, PPEE, and ΔEE were 0.997±0.203, 1.104±0.213, and 0.107±0.134 kcal/min, respectively. Body weight decreased from 68.7±16.6 to 66.8±16.0 kg (p&lt;0.0001) during hospitalization. FEE and PPEE showed positive correlations with height, body weight, body mass index, and abdominal circumference at admission, but ΔEE was not correlated with these anthropometric measurements. On the other hand, ΔEE was inversely correlated with the body weight change. The association between ΔEE and the body weight change was independent of age, sex, and HbA1c. Conclusions: Postprandial increase in energy expenditure may be a determinant of individual differences in weight reduction in patients with type 2 diabetes on diet therapy. As a simple surrogate for diet-induced thermogenesis, ΔEE may serve as a useful predictive marker for the efficacy of diet therapy.</p>},
  author       = {Sanoyama, Daisuke and Nagao, Mototsugu and Asai, Akira and Nakamura, Yuko and Sato, Kazumi and Nakajima, Yasushi and Oikawa, Shinichi and Sugihara, Hitoshi},
  issn         = {1340-3478},
  keyword      = {Diet therapy,Energy expenditure,Type 2 diabetes mellitus},
  language     = {eng},
  number       = {4},
  pages        = {422--429},
  publisher    = {Japan Atherosclerosis Society},
  series       = {Journal of Atherosclerosis and Thrombosis},
  title        = {Postprandial increase in energy expenditure correlates with body weight reduction in patients with type 2 diabetes receiving diet therapy},
  url          = {http://dx.doi.org/10.5551/jat.35303},
  volume       = {24},
  year         = {2017},
}