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Measures of bronchodilator response of FEV1, FVC and SVC in a Swedish general population sample aged 50–64 years, the SCAPIS pilot study

Torén, K; Bake, B; Olin, A. C. LU ; Engström, G. LU ; Blomberg, A. LU ; Vikgren, J; Hedner, J; Brandberg, J; Persson, H L and Sköld, Carl Magnus, et al. (2017) In International Journal of COPD 12. p.973-980
Abstract

Background: Data are lacking from general population studies on how to define changes in lung function after bronchodilation. This study aimed to analyze different measures of bronchodilator response of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and slow vital capacity (SVC). Materials and methods: Data were derived from the Swedish Cardiopulmonary Bioimage Study (SCAPIS) Pilot study. This analysis comprised 1,050 participants aged 50–64 years from the general population. Participants were investigated using a questionnaire, and FEV1, FVC and SVC were recorded before and 15 minutes after inhalation of 400 µg of salbutamol. A bronchodilator response was defined as the relative change... (More)

Background: Data are lacking from general population studies on how to define changes in lung function after bronchodilation. This study aimed to analyze different measures of bronchodilator response of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and slow vital capacity (SVC). Materials and methods: Data were derived from the Swedish Cardiopulmonary Bioimage Study (SCAPIS) Pilot study. This analysis comprised 1,050 participants aged 50–64 years from the general population. Participants were investigated using a questionnaire, and FEV1, FVC and SVC were recorded before and 15 minutes after inhalation of 400 µg of salbutamol. A bronchodilator response was defined as the relative change from baseline value expressed as the difference in units of percent predicted normal. Predictors of bronchodilator responses were assessed using multiple linear regression models. Airway obstruction was defined as FEV1/FVC ratio below lower limit of normal (LLN) before bronchodilation, and COPD was defined as an FEV1/FVC ratio below LLN after bronchodilation. Physician-diagnosed asthma was defined as an affirmative answer to “Have you ever had asthma diagnosed by a physician?”. Asymptomatic never-smokers were defined as those not reporting physician-diagnosed asthma, physician-diagnosed COPD or emphysema, current wheeze or chronic bronchitis and being a lifelong never-smoker. Results: Among all subjects, the greatest bronchodilator responses (FEV1, FVC and SVC) were found in subjects with asthma or COPD. The upper 95th percentile of bronchodilator responses in asymptomatic never-smokers was 8.7% for FEV1, 4.2% for FVC and 5.0% for SVC. The bronchodilator responses were similar between men and women. In a multiple linear regression model comprising all asymptomatic never-smokers, the bronchodilator response of FEV1 was significantly associated with airway obstruction and height. Conclusion: When the bronchodilator response in asymptomatic never-smokers is reported as the difference in units of predicted normal, significant reversibility of FEV1, FVC and SVC to bronchodilators is ~9%, 4% and 5%, respectively.

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published
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keywords
COPD, Epidemiology, Reversibility, Spirometry
in
International Journal of COPD
volume
12
pages
8 pages
publisher
Dove Press
external identifiers
  • scopus:85016157741
  • pmid:28356729
  • wos:000397423200025
ISSN
1176-9106
DOI
10.2147/COPD.S127336
language
English
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yes
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d78a9247-6d27-461c-9a06-2e5e1a940b12
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2017-04-21 14:06:04
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2017-09-18 13:32:53
@article{d78a9247-6d27-461c-9a06-2e5e1a940b12,
  abstract     = {<p>Background: Data are lacking from general population studies on how to define changes in lung function after bronchodilation. This study aimed to analyze different measures of bronchodilator response of forced expiratory volume in 1 second (FEV<sub>1</sub>), forced vital capacity (FVC) and slow vital capacity (SVC). Materials and methods: Data were derived from the Swedish Cardiopulmonary Bioimage Study (SCAPIS) Pilot study. This analysis comprised 1,050 participants aged 50–64 years from the general population. Participants were investigated using a questionnaire, and FEV<sub>1</sub>, FVC and SVC were recorded before and 15 minutes after inhalation of 400 µg of salbutamol. A bronchodilator response was defined as the relative change from baseline value expressed as the difference in units of percent predicted normal. Predictors of bronchodilator responses were assessed using multiple linear regression models. Airway obstruction was defined as FEV<sub>1</sub>/FVC ratio below lower limit of normal (LLN) before bronchodilation, and COPD was defined as an FEV<sub>1</sub>/FVC ratio below LLN after bronchodilation. Physician-diagnosed asthma was defined as an affirmative answer to “Have you ever had asthma diagnosed by a physician?”. Asymptomatic never-smokers were defined as those not reporting physician-diagnosed asthma, physician-diagnosed COPD or emphysema, current wheeze or chronic bronchitis and being a lifelong never-smoker. Results: Among all subjects, the greatest bronchodilator responses (FEV<sub>1</sub>, FVC and SVC) were found in subjects with asthma or COPD. The upper 95th percentile of bronchodilator responses in asymptomatic never-smokers was 8.7% for FEV<sub>1</sub>, 4.2% for FVC and 5.0% for SVC. The bronchodilator responses were similar between men and women. In a multiple linear regression model comprising all asymptomatic never-smokers, the bronchodilator response of FEV<sub>1</sub> was significantly associated with airway obstruction and height. Conclusion: When the bronchodilator response in asymptomatic never-smokers is reported as the difference in units of predicted normal, significant reversibility of FEV<sub>1</sub>, FVC and SVC to bronchodilators is ~9%, 4% and 5%, respectively.</p>},
  author       = {Torén, K and Bake, B and Olin, A. C. and Engström, G. and Blomberg, A. and Vikgren, J and Hedner, J and Brandberg, J and Persson, H L and Sköld, Carl Magnus and Rosengren, A. and Bergström, G and Janson, C},
  issn         = {1176-9106},
  keyword      = {COPD,Epidemiology,Reversibility,Spirometry},
  language     = {eng},
  month        = {03},
  pages        = {973--980},
  publisher    = {Dove Press},
  series       = {International Journal of COPD},
  title        = {Measures of bronchodilator response of FEV<sub>1</sub>, FVC and SVC in a Swedish general population sample aged 50–64 years, the SCAPIS pilot study},
  url          = {http://dx.doi.org/10.2147/COPD.S127336},
  volume       = {12},
  year         = {2017},
}