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Heritability of cilioretinal arteries: a twin study

Taarnhøj, Nina Charlotte Bille Brahe; Munch, Inger Christine; Kyvik, Kirsten Ohm; Sander, Birgit; Kessel, Line; Sørensen, Thorkild I A; Hougaard, Jesper Leth LU and Larsen, Michael (2005) In Investigative Ophthalmology & Visual Science 46(10). p.3850-3854
Abstract (Swedish)
Abstract
PURPOSE: To determine whether the presence of one or more cilioretinal arteries, a distinct element of the pattern of fundus vessels, is genetically programmed, influenced by environmental factors, or the result of random mechanisms of vascular development. METHODS: The fundi of 112 pairs of healthy monozygotic and dizygotic twins were examined using digital fundus photography and visual assessment of grayscale fundus photographs and color transparencies to detect the presence of cilioretinal arteries. RESULTS: Cilioretinal arteries were present in 45.1% of participants and 28.8% of eyes. The majority of cilioretinal arteries, 88.2%, were located temporally, and 11.8% were located nasally. Monozygotic twins had higher... (More)
Abstract
PURPOSE: To determine whether the presence of one or more cilioretinal arteries, a distinct element of the pattern of fundus vessels, is genetically programmed, influenced by environmental factors, or the result of random mechanisms of vascular development. METHODS: The fundi of 112 pairs of healthy monozygotic and dizygotic twins were examined using digital fundus photography and visual assessment of grayscale fundus photographs and color transparencies to detect the presence of cilioretinal arteries. RESULTS: Cilioretinal arteries were present in 45.1% of participants and 28.8% of eyes. The majority of cilioretinal arteries, 88.2%, were located temporally, and 11.8% were located nasally. Monozygotic twins had higher concordance rates for cilioretinal arteries than dizygotic twins. Tetrachoric correlations and Mantel-Haenszel odds ratios demonstrated statistically significant evidence of a genetic effect underlying the presence of cilioretinal arteries (P < 0.01). Statistical analysis supported the hypothesis that additive genetic factors influenced the presence of cilioretinal arteries with a heritability of 71.4%, the remaining variance being attributable to nonshared or random environmental factors. CONCLUSIONS:
The presence or absence of one or more cilioretinal arteries in healthy persons is markedly influenced by genetic factors. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Investigative Ophthalmology & Visual Science
volume
46
issue
10
pages
3850 - 3854
publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
external identifiers
  • scopus:32944474173
  • pmid:16186373
ISSN
1552-5783
DOI
10.1167/iovs.05-0177
language
English
LU publication?
no
id
d7a6a68c-35b4-4209-a68d-13bbd96d4d12
date added to LUP
2019-06-13 12:40:18
date last changed
2019-09-17 04:56:18
@article{d7a6a68c-35b4-4209-a68d-13bbd96d4d12,
  abstract     = {Abstract<br>
PURPOSE: To determine whether the presence of one or more cilioretinal arteries, a distinct element of the pattern of fundus vessels, is genetically programmed, influenced by environmental factors, or the result of random mechanisms of vascular development. METHODS: The fundi of 112 pairs of healthy monozygotic and dizygotic twins were examined using digital fundus photography and visual assessment of grayscale fundus photographs and color transparencies to detect the presence of cilioretinal arteries. RESULTS: Cilioretinal arteries were present in 45.1% of participants and 28.8% of eyes. The majority of cilioretinal arteries, 88.2%, were located temporally, and 11.8% were located nasally. Monozygotic twins had higher concordance rates for cilioretinal arteries than dizygotic twins. Tetrachoric correlations and Mantel-Haenszel odds ratios demonstrated statistically significant evidence of a genetic effect underlying the presence of cilioretinal arteries (P &lt; 0.01). Statistical analysis supported the hypothesis that additive genetic factors influenced the presence of cilioretinal arteries with a heritability of 71.4%, the remaining variance being attributable to nonshared or random environmental factors. CONCLUSIONS:<br>
The presence or absence of one or more cilioretinal arteries in healthy persons is markedly influenced by genetic factors.},
  author       = {Taarnhøj, Nina Charlotte Bille Brahe and Munch, Inger Christine and Kyvik, Kirsten Ohm and Sander, Birgit and Kessel, Line and Sørensen, Thorkild I A and Hougaard, Jesper Leth and Larsen, Michael},
  issn         = {1552-5783},
  language     = {eng},
  number       = {10},
  pages        = {3850--3854},
  publisher    = {ASSOC RESEARCH VISION OPHTHALMOLOGY INC},
  series       = {Investigative Ophthalmology & Visual Science},
  title        = {Heritability of cilioretinal arteries: a twin study},
  url          = {http://dx.doi.org/10.1167/iovs.05-0177},
  volume       = {46},
  year         = {2005},
}