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Interplay between amphiphilic peptides and nanoparticles for selective membrane destabilization and antimicrobial effects

Malekkhaiat Häffner, Sara and Malmsten, Martin LU (2019) In Current Opinion in Colloid and Interface Science 44. p.59-71
Abstract

As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are attracting significant interest, particularly in relation to identification of peptides displaying potent but selective effects. Much less focus has been placed on delivery systems for AMPs, despite AMPs suffering from delivery challenges related to their size, cationicity, and amphiphilicity. Inorganic nanoparticles may provide opportunities for controlling peptide release, reducing infection-related AMP degradation, or increasing bioavailability. Numerous such nanomaterials display potent and triggerable antimicrobial effects on their own. When combined with AMPs, combinatorial and synergistic effects in... (More)

As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are attracting significant interest, particularly in relation to identification of peptides displaying potent but selective effects. Much less focus has been placed on delivery systems for AMPs, despite AMPs suffering from delivery challenges related to their size, cationicity, and amphiphilicity. Inorganic nanoparticles may provide opportunities for controlling peptide release, reducing infection-related AMP degradation, or increasing bioavailability. Numerous such nanomaterials display potent and triggerable antimicrobial effects on their own. When combined with AMPs, combinatorial and synergistic effects in relation to the behavior of such mixed systems as antimicrobials have been observed. The mechanistic origin of these effects are poorly understood that at present, however, precluding rational design of mixed nanoparticle antimicrobials/AMPs and nanoparticulate delivery systems for AMPs. Here, the area of membrane interactions and antimicrobial effects of inorganic nanomaterials are briefly outlined, in combination with AMPs.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antimicrobial peptide, Bilayer, Drug delivery, Membrane, Nanoparticle
in
Current Opinion in Colloid and Interface Science
volume
44
pages
13 pages
publisher
Elsevier
external identifiers
  • scopus:85074405101
ISSN
1359-0294
DOI
10.1016/j.cocis.2019.09.004
language
English
LU publication?
yes
id
d7ec52bb-a750-4cc1-b923-5514c356de73
date added to LUP
2019-11-15 13:39:09
date last changed
2020-01-13 02:31:38
@article{d7ec52bb-a750-4cc1-b923-5514c356de73,
  abstract     = {<p>As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are attracting significant interest, particularly in relation to identification of peptides displaying potent but selective effects. Much less focus has been placed on delivery systems for AMPs, despite AMPs suffering from delivery challenges related to their size, cationicity, and amphiphilicity. Inorganic nanoparticles may provide opportunities for controlling peptide release, reducing infection-related AMP degradation, or increasing bioavailability. Numerous such nanomaterials display potent and triggerable antimicrobial effects on their own. When combined with AMPs, combinatorial and synergistic effects in relation to the behavior of such mixed systems as antimicrobials have been observed. The mechanistic origin of these effects are poorly understood that at present, however, precluding rational design of mixed nanoparticle antimicrobials/AMPs and nanoparticulate delivery systems for AMPs. Here, the area of membrane interactions and antimicrobial effects of inorganic nanomaterials are briefly outlined, in combination with AMPs.</p>},
  author       = {Malekkhaiat Häffner, Sara and Malmsten, Martin},
  issn         = {1359-0294},
  language     = {eng},
  pages        = {59--71},
  publisher    = {Elsevier},
  series       = {Current Opinion in Colloid and Interface Science},
  title        = {Interplay between amphiphilic peptides and nanoparticles for selective membrane destabilization and antimicrobial effects},
  url          = {http://dx.doi.org/10.1016/j.cocis.2019.09.004},
  doi          = {10.1016/j.cocis.2019.09.004},
  volume       = {44},
  year         = {2019},
}