Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors.
(2001)- Abstract
- The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber... (More)
- The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber degeneration. The findings have implications for the development of effective neuroprotective and restorative therapeutic interventions for Parkinson’s disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/41285
- author
- Kirik, Deniz LU
- supervisor
- opponent
-
- Prof Dunnett, Stephen B.
- organization
- publishing date
- 2001
- type
- Thesis
- publication status
- published
- subject
- keywords
- adeno-associated virus, regeneration, neuroprotection, glial-cell-line-derived-neurotrophic factor, cell death, substantia nigra, dopamine, neurofysiologi, neuropsykologi, Neurologi, neurophysiology, neuropsychology, Neurology, tyrosine hydroxylase, sensorimotor behavior, transplantation, gene therapy
- pages
- 172 pages
- publisher
- Department of Physiological Sciences, Lund University
- defense location
- Segerfalksalen, Wallenberg Neurocentrum, Lund
- defense date
- 2001-03-16 10:15:00
- ISBN
- 91-628-4679-5
- language
- English
- LU publication?
- yes
- id
- d7f62e21-99fa-4c2e-81d4-2c045f6e41fb (old id 41285)
- date added to LUP
- 2016-04-04 11:32:54
- date last changed
- 2018-11-21 21:05:34
@phdthesis{d7f62e21-99fa-4c2e-81d4-2c045f6e41fb,
abstract = {{The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber degeneration. The findings have implications for the development of effective neuroprotective and restorative therapeutic interventions for Parkinson’s disease.}},
author = {{Kirik, Deniz}},
isbn = {{91-628-4679-5}},
keywords = {{adeno-associated virus; regeneration; neuroprotection; glial-cell-line-derived-neurotrophic factor; cell death; substantia nigra; dopamine; neurofysiologi; neuropsykologi; Neurologi; neurophysiology; neuropsychology; Neurology; tyrosine hydroxylase; sensorimotor behavior; transplantation; gene therapy}},
language = {{eng}},
publisher = {{Department of Physiological Sciences, Lund University}},
school = {{Lund University}},
title = {{Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors.}},
year = {{2001}},
}