Biomechanical factors associated with the development of tibiofemoral knee osteoarthritis : Protocol for a systematic review and meta-analysis
(2016) In BMJ Open 6.- Abstract
Introduction: Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of ) KOA and (2) to identify the impact of other... (More)
Introduction: Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of ) KOA and (2) to identify the impact of other relevant risk factors on this association. Methods and analysis: Cohort, cross-sectional and case-control studies investigating the association of a biomechanical factor with (the development of ) KOA will be included. MEDLINE, EMBASE, CINAHL and SPORTDiscus will be searched from their inception until August 2015. 2 reviewers will independently screen articles obtained by the search for eligibility, extract data and score risk of bias. Quality of evidence will be evaluated. Meta-analysis using random effects model will be applied in each of the biomechanical factors, if possible. Ethics and dissemination: This systematic review and meta-analysis does not require ethical approval. The results of this systematic review and meta-analysis will be disseminated through publications in peerreviewed journals and presentations at (inter)national conferences.
(Less)
- author
- Tunen, Joyce A.C.Van ; Dell'isola, Andrea LU ; Juhl, Carsten ; Dekker, Joost ; Steultjens, Martijn and Lund, Hans
- publishing date
- 2016-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMJ Open
- volume
- 6
- article number
- e011066
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:27311908
- scopus:84975267250
- ISSN
- 2044-6055
- DOI
- 10.1136/bmjopen-2016-011066
- language
- English
- LU publication?
- no
- id
- d80571a8-e286-4ef7-8d23-d1c9c2ed00ad
- date added to LUP
- 2024-09-15 17:06:04
- date last changed
- 2025-04-14 13:08:50
@article{d80571a8-e286-4ef7-8d23-d1c9c2ed00ad,
abstract = {{<p>Introduction: Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of ) KOA and (2) to identify the impact of other relevant risk factors on this association. Methods and analysis: Cohort, cross-sectional and case-control studies investigating the association of a biomechanical factor with (the development of ) KOA will be included. MEDLINE, EMBASE, CINAHL and SPORTDiscus will be searched from their inception until August 2015. 2 reviewers will independently screen articles obtained by the search for eligibility, extract data and score risk of bias. Quality of evidence will be evaluated. Meta-analysis using random effects model will be applied in each of the biomechanical factors, if possible. Ethics and dissemination: This systematic review and meta-analysis does not require ethical approval. The results of this systematic review and meta-analysis will be disseminated through publications in peerreviewed journals and presentations at (inter)national conferences.</p>}},
author = {{Tunen, Joyce A.C.Van and Dell'isola, Andrea and Juhl, Carsten and Dekker, Joost and Steultjens, Martijn and Lund, Hans}},
issn = {{2044-6055}},
language = {{eng}},
month = {{06}},
publisher = {{BMJ Publishing Group}},
series = {{BMJ Open}},
title = {{Biomechanical factors associated with the development of tibiofemoral knee osteoarthritis : Protocol for a systematic review and meta-analysis}},
url = {{http://dx.doi.org/10.1136/bmjopen-2016-011066}},
doi = {{10.1136/bmjopen-2016-011066}},
volume = {{6}},
year = {{2016}},
}