Functional imaging for assessing regional lung ventilation in preclinical and clinical research
(2023) In Frontiers in Medicine 10.- Abstract
Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function and may be characteristic of early pulmonary disease. While standard indices like spirometry, body plethysmography, and blood gases have been utilized to assess lung function, they do not provide adequate information on regional ventilatory distribution nor function assessments of ventilation during the respiratory cycle. Emerging technologies such as xenon CT, volumetric CT, functional MRI and X-ray velocimetry can assess regional ventilation using non-invasive radiographic methods that may complement current methods of assessing lung function. As a supplement to current modalities of pulmonary function assessment, functional lung imaging has the... (More)
Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function and may be characteristic of early pulmonary disease. While standard indices like spirometry, body plethysmography, and blood gases have been utilized to assess lung function, they do not provide adequate information on regional ventilatory distribution nor function assessments of ventilation during the respiratory cycle. Emerging technologies such as xenon CT, volumetric CT, functional MRI and X-ray velocimetry can assess regional ventilation using non-invasive radiographic methods that may complement current methods of assessing lung function. As a supplement to current modalities of pulmonary function assessment, functional lung imaging has the potential to identify respiratory disease phenotypes with distinct natural histories. Moreover, these novel technologies may offer an optimal strategy to evaluate the effectiveness of novel therapies and therapies targeting localized small airways disease in preclinical and clinical research. In this review, we aim to discuss the features of functional lung imaging, as well as its potential application and limitations to adoption in research.
(Less)
- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 4DCT, functional lung imaging, functional MRI, velocimetery, ventilation heterogeneity
- in
- Frontiers in Medicine
- volume
- 10
- article number
- 1160292
- publisher
- Frontiers Media S. A.
- external identifiers
-
- pmid:37261124
- scopus:85161029713
- ISSN
- 2296-858X
- DOI
- 10.3389/fmed.2023.1160292
- language
- English
- LU publication?
- yes
- id
- d80ba3d6-300e-4719-a6af-3489a06670b0
- date added to LUP
- 2023-08-31 15:38:05
- date last changed
- 2024-04-20 03:22:03
@article{d80ba3d6-300e-4719-a6af-3489a06670b0,
abstract = {{<p>Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function and may be characteristic of early pulmonary disease. While standard indices like spirometry, body plethysmography, and blood gases have been utilized to assess lung function, they do not provide adequate information on regional ventilatory distribution nor function assessments of ventilation during the respiratory cycle. Emerging technologies such as xenon CT, volumetric CT, functional MRI and X-ray velocimetry can assess regional ventilation using non-invasive radiographic methods that may complement current methods of assessing lung function. As a supplement to current modalities of pulmonary function assessment, functional lung imaging has the potential to identify respiratory disease phenotypes with distinct natural histories. Moreover, these novel technologies may offer an optimal strategy to evaluate the effectiveness of novel therapies and therapies targeting localized small airways disease in preclinical and clinical research. In this review, we aim to discuss the features of functional lung imaging, as well as its potential application and limitations to adoption in research.</p>}},
author = {{Karmali, Dipan and Sowho, Mudiaga and Bose, Sonali and Pearce, Jackson and Tejwani, Vickram and Diamant, Zuzana and Yarlagadda, Keerthi and Ponce, Erick and Eikelis, Nina and Otvos, Tamas and Khan, Akram and Lester, Michael and Fouras, Andreas and Kirkness, Jason and Siddharthan, Trishul}},
issn = {{2296-858X}},
keywords = {{4DCT; functional lung imaging; functional MRI; velocimetery; ventilation heterogeneity}},
language = {{eng}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Medicine}},
title = {{Functional imaging for assessing regional lung ventilation in preclinical and clinical research}},
url = {{http://dx.doi.org/10.3389/fmed.2023.1160292}},
doi = {{10.3389/fmed.2023.1160292}},
volume = {{10}},
year = {{2023}},
}