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Can mechanical imaging increase the specificity of mammography screening?

Dustler, Magnus LU ; Förnvik, Daniel LU ; Timberg, Pontus LU ; Andersson, Ingvar LU ; Petersson, Hannie LU ; Brorson, Håkan LU ; Tingberg, Anders LU and Zackrisson, Sophia LU (2017) In European Radiology 27(8). p.3217-3225
Abstract

Objectives: This study aimed to investigate the effects of adding adjunct mechanical imaging to mammography breast screening. We hypothesized that mechanical imaging could detect increased local pressure caused by both malignant and benign breast lesions and that a pressure threshold for malignancy could be established. The impact of this on breast screening was investigated with regard to reductions in recall and biopsy rates. Methods: 155 women recalled from breast screening were included in the study, which was approved by the regional ethical review board (dnr 2013/620). Mechanical imaging readings were acquired of the symptomatic breast. The relative mean pressure on the suspicious area (RMPA) was defined and a threshold for... (More)

Objectives: This study aimed to investigate the effects of adding adjunct mechanical imaging to mammography breast screening. We hypothesized that mechanical imaging could detect increased local pressure caused by both malignant and benign breast lesions and that a pressure threshold for malignancy could be established. The impact of this on breast screening was investigated with regard to reductions in recall and biopsy rates. Methods: 155 women recalled from breast screening were included in the study, which was approved by the regional ethical review board (dnr 2013/620). Mechanical imaging readings were acquired of the symptomatic breast. The relative mean pressure on the suspicious area (RMPA) was defined and a threshold for malignancy was established. Results: Biopsy-proven invasive cancers had a median RMPA of 3.0 (interquartile range (IQR) = 3.7), significantly different from biopsy-proven benign at 1.3 (IQR = 1.0) and non-biopsied cases at 1.0 (IQR = 1.3) (P < 0.001). The lowest RMPA for invasive cancer was 1.4, with 23 biopsy-proven benign and 33 non-biopsied cases being below this limit. Had these women not been recalled, recall rates would have been reduced by 36% and biopsy rates by 32%. Conclusions: If implemented in a screening situation, this may substantially lower the number of false positives. Key Points: • Mechanical imaging is used as an adjunct to mammography in breast screening.• A threshold pressure can be established for malignant breast cancer.• Recalls and biopsies can be substantially reduced.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biopsy rate, Breast screening, Mammography, Mechanical imaging, Recall rates
in
European Radiology
volume
27
issue
8
pages
9 pages
publisher
Springer
external identifiers
  • scopus:85009892081
  • wos:000404655200012
ISSN
0938-7994
DOI
10.1007/s00330-016-4723-6
language
English
LU publication?
yes
id
d8277dec-955d-4396-a233-7ce0c1f78c4a
date added to LUP
2017-02-06 08:41:59
date last changed
2018-01-07 11:48:32
@article{d8277dec-955d-4396-a233-7ce0c1f78c4a,
  abstract     = {<p>Objectives: This study aimed to investigate the effects of adding adjunct mechanical imaging to mammography breast screening. We hypothesized that mechanical imaging could detect increased local pressure caused by both malignant and benign breast lesions and that a pressure threshold for malignancy could be established. The impact of this on breast screening was investigated with regard to reductions in recall and biopsy rates. Methods: 155 women recalled from breast screening were included in the study, which was approved by the regional ethical review board (dnr 2013/620). Mechanical imaging readings were acquired of the symptomatic breast. The relative mean pressure on the suspicious area (RMPA) was defined and a threshold for malignancy was established. Results: Biopsy-proven invasive cancers had a median RMPA of 3.0 (interquartile range (IQR) = 3.7), significantly different from biopsy-proven benign at 1.3 (IQR = 1.0) and non-biopsied cases at 1.0 (IQR = 1.3) (P &lt; 0.001). The lowest RMPA for invasive cancer was 1.4, with 23 biopsy-proven benign and 33 non-biopsied cases being below this limit. Had these women not been recalled, recall rates would have been reduced by 36% and biopsy rates by 32%. Conclusions: If implemented in a screening situation, this may substantially lower the number of false positives. Key Points: • Mechanical imaging is used as an adjunct to mammography in breast screening.• A threshold pressure can be established for malignant breast cancer.• Recalls and biopsies can be substantially reduced.</p>},
  author       = {Dustler, Magnus and Förnvik, Daniel and Timberg, Pontus and Andersson, Ingvar and Petersson, Hannie and Brorson, Håkan and Tingberg, Anders and Zackrisson, Sophia},
  issn         = {0938-7994},
  keyword      = {Biopsy rate,Breast screening,Mammography,Mechanical imaging,Recall rates},
  language     = {eng},
  month        = {01},
  number       = {8},
  pages        = {3217--3225},
  publisher    = {Springer},
  series       = {European Radiology},
  title        = {Can mechanical imaging increase the specificity of mammography screening?},
  url          = {http://dx.doi.org/10.1007/s00330-016-4723-6},
  volume       = {27},
  year         = {2017},
}