Peritoneal metastases from small bowel cancer : Results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in The Netherlands
(2015) In Surgery 157(6). p.7-1023- Abstract
INTRODUCTION: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) is currently considered the standard of care for pseudomyxoma peritonei, mesothelioma and peritoneal metastases (PM) from colorectal cancer. CRS + HIPEC has also been suggested as a potential treatment option in PM of the much rarer small bowel cancer. Therefore, the current study was undertaken to investigate the results of CRS + HIPEC in all HIPEC centers in The Netherlands.
METHODS: From the 4 tertiary referral centers for peritoneal surface malignancies in The Netherlands, data from all patients with peritoneally metastasized small bowel carcinoma intended to undergo CRS and HIPEC were collected between January 2005 and July 2014.... (More)
INTRODUCTION: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) is currently considered the standard of care for pseudomyxoma peritonei, mesothelioma and peritoneal metastases (PM) from colorectal cancer. CRS + HIPEC has also been suggested as a potential treatment option in PM of the much rarer small bowel cancer. Therefore, the current study was undertaken to investigate the results of CRS + HIPEC in all HIPEC centers in The Netherlands.
METHODS: From the 4 tertiary referral centers for peritoneal surface malignancies in The Netherlands, data from all patients with peritoneally metastasized small bowel carcinoma intended to undergo CRS and HIPEC were collected between January 2005 and July 2014. Primary tumor characteristics, operative details, and survival outcomes were collected.
RESULTS: Sixteen of 19 patients (84.2%) who underwent explorative laparotomy underwent CRS + HIPEC. Of these patients, 81.3% were female, and primary tumors were mainly located in the ileum (50%). A complete macroscopic resection was achieved in 93.8%. Serious adverse events requiring re-intervention occurred in 25%, and no in-hospital mortality was observed. Recurrent disease was observed in 50% of patients and median survival after CRS and HIPEC was 31 months.
CONCLUSION: In a select group of patients in whom a complete macroscopic resection can be achieved, survival rates comparable with those in colorectal PM are attainable with acceptable morbidity. The role of adjuvant chemotherapy needs further research.
(Less)
- author
- van Oudheusden, Thijs R ; Lemmens, Valery E ; Braam, Hidde J ; van Ramshorst, Bert ; Meijerink, Jeroen ; te Velde, Eline A ; Mehta, Akash M ; Verwaal, Vic J LU and de Hingh, Ignace H
- publishing date
- 2015-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adenocarcinoma/secondary, Adult, Aged, Chemotherapy, Cancer, Regional Perfusion/methods, Combined Modality Therapy, Cytoreduction Surgical Procedures/methods, Databases, Factual, Disease-Free Survival, Female, Humans, Hypothermia, Induced, Intestinal Neoplasms/pathology, Intestine, Small/pathology, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Recurrence, Local/mortality, Netherlands, Peritoneal Neoplasms/mortality, Prognosis, Retrospective Studies, Risk Assessment, Survival Analysis, Tertiary Care Centers, Treatment Outcome
- in
- Surgery
- volume
- 157
- issue
- 6
- pages
- 7 - 1023
- publisher
- Elsevier
- external identifiers
-
- pmid:25818658
- scopus:84929284388
- ISSN
- 1532-7361
- DOI
- 10.1016/j.surg.2015.01.021
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2015 Elsevier Inc. All rights reserved.
- id
- d851e247-e240-4084-b459-011aa6f4768c
- date added to LUP
- 2022-04-05 09:40:46
- date last changed
- 2024-04-10 04:24:23
@article{d851e247-e240-4084-b459-011aa6f4768c,
abstract = {{<p>INTRODUCTION: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) is currently considered the standard of care for pseudomyxoma peritonei, mesothelioma and peritoneal metastases (PM) from colorectal cancer. CRS + HIPEC has also been suggested as a potential treatment option in PM of the much rarer small bowel cancer. Therefore, the current study was undertaken to investigate the results of CRS + HIPEC in all HIPEC centers in The Netherlands.</p><p>METHODS: From the 4 tertiary referral centers for peritoneal surface malignancies in The Netherlands, data from all patients with peritoneally metastasized small bowel carcinoma intended to undergo CRS and HIPEC were collected between January 2005 and July 2014. Primary tumor characteristics, operative details, and survival outcomes were collected.</p><p>RESULTS: Sixteen of 19 patients (84.2%) who underwent explorative laparotomy underwent CRS + HIPEC. Of these patients, 81.3% were female, and primary tumors were mainly located in the ileum (50%). A complete macroscopic resection was achieved in 93.8%. Serious adverse events requiring re-intervention occurred in 25%, and no in-hospital mortality was observed. Recurrent disease was observed in 50% of patients and median survival after CRS and HIPEC was 31 months.</p><p>CONCLUSION: In a select group of patients in whom a complete macroscopic resection can be achieved, survival rates comparable with those in colorectal PM are attainable with acceptable morbidity. The role of adjuvant chemotherapy needs further research.</p>}},
author = {{van Oudheusden, Thijs R and Lemmens, Valery E and Braam, Hidde J and van Ramshorst, Bert and Meijerink, Jeroen and te Velde, Eline A and Mehta, Akash M and Verwaal, Vic J and de Hingh, Ignace H}},
issn = {{1532-7361}},
keywords = {{Adenocarcinoma/secondary; Adult; Aged; Chemotherapy, Cancer, Regional Perfusion/methods; Combined Modality Therapy; Cytoreduction Surgical Procedures/methods; Databases, Factual; Disease-Free Survival; Female; Humans; Hypothermia, Induced; Intestinal Neoplasms/pathology; Intestine, Small/pathology; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local/mortality; Netherlands; Peritoneal Neoplasms/mortality; Prognosis; Retrospective Studies; Risk Assessment; Survival Analysis; Tertiary Care Centers; Treatment Outcome}},
language = {{eng}},
number = {{6}},
pages = {{7--1023}},
publisher = {{Elsevier}},
series = {{Surgery}},
title = {{Peritoneal metastases from small bowel cancer : Results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in The Netherlands}},
url = {{http://dx.doi.org/10.1016/j.surg.2015.01.021}},
doi = {{10.1016/j.surg.2015.01.021}},
volume = {{157}},
year = {{2015}},
}