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Computational health engineering applied to model infectious diseases and antimicrobial resistance spread

Gestal, Mónica Cartelle; Dedloff, Margaret R. and Torres-Sangiao, Eva LU (2019) In Applied Sciences (Switzerland) 9(12).
Abstract

Infectious diseases are the primary cause of mortality worldwide. The dangers of infectious disease are compounded with antimicrobial resistance, which remains the greatest concern for human health. Although novel approaches are under investigation, the World Health Organization predicts that by 2050, septicaemia caused by antimicrobial resistant bacteria could result in 10 million deaths per year. One of the main challenges in medical microbiology is to develop novel experimental approaches, which enable a better understanding of bacterial infections and antimicrobial resistance. After the introduction of whole genome sequencing, there was a great improvement in bacterial detection and identification, which also enabled the... (More)

Infectious diseases are the primary cause of mortality worldwide. The dangers of infectious disease are compounded with antimicrobial resistance, which remains the greatest concern for human health. Although novel approaches are under investigation, the World Health Organization predicts that by 2050, septicaemia caused by antimicrobial resistant bacteria could result in 10 million deaths per year. One of the main challenges in medical microbiology is to develop novel experimental approaches, which enable a better understanding of bacterial infections and antimicrobial resistance. After the introduction of whole genome sequencing, there was a great improvement in bacterial detection and identification, which also enabled the characterization of virulence factors and antimicrobial resistance genes. Today, the use of in silico experiments jointly with computational and machine learning offer an in depth understanding of systems biology, allowing us to use this knowledge for the prevention, prediction, and control of infectious disease. Herein, the aim of this review is to discuss the latest advances in human health engineering and their applicability in the control of infectious diseases. An in-depth knowledge of host-pathogen-protein interactions, combined with a better understanding of a host's immune response and bacterial fitness, are key determinants for halting infectious diseases and antimicrobial resistance dissemination.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antimicrobial resistance, Health engineering, Infection disease, Mathematic models
in
Applied Sciences (Switzerland)
volume
9
issue
12
publisher
Multidisciplinary Digital Publishing Institute (MDPI)
external identifiers
  • scopus:85068170723
DOI
10.3390/app9122486
language
English
LU publication?
yes
id
d886d51c-dd1b-4e09-801c-1b4161bd2e6d
date added to LUP
2019-07-09 16:44:02
date last changed
2019-08-06 03:23:59
@article{d886d51c-dd1b-4e09-801c-1b4161bd2e6d,
  abstract     = {<p>Infectious diseases are the primary cause of mortality worldwide. The dangers of infectious disease are compounded with antimicrobial resistance, which remains the greatest concern for human health. Although novel approaches are under investigation, the World Health Organization predicts that by 2050, septicaemia caused by antimicrobial resistant bacteria could result in 10 million deaths per year. One of the main challenges in medical microbiology is to develop novel experimental approaches, which enable a better understanding of bacterial infections and antimicrobial resistance. After the introduction of whole genome sequencing, there was a great improvement in bacterial detection and identification, which also enabled the characterization of virulence factors and antimicrobial resistance genes. Today, the use of in silico experiments jointly with computational and machine learning offer an in depth understanding of systems biology, allowing us to use this knowledge for the prevention, prediction, and control of infectious disease. Herein, the aim of this review is to discuss the latest advances in human health engineering and their applicability in the control of infectious diseases. An in-depth knowledge of host-pathogen-protein interactions, combined with a better understanding of a host's immune response and bacterial fitness, are key determinants for halting infectious diseases and antimicrobial resistance dissemination.</p>},
  articleno    = {2486},
  author       = {Gestal, Mónica Cartelle and Dedloff, Margaret R. and Torres-Sangiao, Eva},
  keyword      = {Antimicrobial resistance,Health engineering,Infection disease,Mathematic models},
  language     = {eng},
  number       = {12},
  publisher    = {Multidisciplinary Digital Publishing Institute (MDPI)},
  series       = {Applied Sciences (Switzerland)},
  title        = {Computational health engineering applied to model infectious diseases and antimicrobial resistance spread},
  url          = {http://dx.doi.org/10.3390/app9122486},
  volume       = {9},
  year         = {2019},
}