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Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents

Ottesen, Lars K. ; Ek, Fredrik LU orcid and Olsson, Roger LU orcid (2006) In Organic Letters 8(9). p.1771-1773
Abstract

A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO2Me) gave excellent yields (89%).

Please use this url to cite or link to this publication:
author
; and
publishing date
type
Contribution to journal
publication status
published
in
Organic Letters
volume
8
issue
9
pages
3 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:33646450274
  • pmid:16623547
ISSN
1523-7060
DOI
10.1021/ol0600234
language
English
LU publication?
no
id
d88b0bfa-c504-4d50-99f0-17ab40e82843
date added to LUP
2019-10-02 09:58:28
date last changed
2025-10-14 10:48:06
@article{d88b0bfa-c504-4d50-99f0-17ab40e82843,
  abstract     = {{<p>A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO<sub>2</sub>Me) gave excellent yields (89%).</p>}},
  author       = {{Ottesen, Lars K. and Ek, Fredrik and Olsson, Roger}},
  issn         = {{1523-7060}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{9}},
  pages        = {{1771--1773}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Organic Letters}},
  title        = {{Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents}},
  url          = {{http://dx.doi.org/10.1021/ol0600234}},
  doi          = {{10.1021/ol0600234}},
  volume       = {{8}},
  year         = {{2006}},
}