Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents
(2006) In Organic Letters 8(9). p.1771-1773- Abstract
A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO2Me) gave excellent yields (89%).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/d88b0bfa-c504-4d50-99f0-17ab40e82843
- author
- Ottesen, Lars K. ; Ek, Fredrik LU and Olsson, Roger LU
- publishing date
- 2006-04-27
- type
- Contribution to journal
- publication status
- published
- in
- Organic Letters
- volume
- 8
- issue
- 9
- pages
- 3 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:16623547
- scopus:33646450274
- ISSN
- 1523-7060
- DOI
- 10.1021/ol0600234
- language
- English
- LU publication?
- no
- id
- d88b0bfa-c504-4d50-99f0-17ab40e82843
- date added to LUP
- 2019-10-02 09:58:28
- date last changed
- 2024-05-29 01:34:08
@article{d88b0bfa-c504-4d50-99f0-17ab40e82843, abstract = {{<p>A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO<sub>2</sub>Me) gave excellent yields (89%).</p>}}, author = {{Ottesen, Lars K. and Ek, Fredrik and Olsson, Roger}}, issn = {{1523-7060}}, language = {{eng}}, month = {{04}}, number = {{9}}, pages = {{1771--1773}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Organic Letters}}, title = {{Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents}}, url = {{http://dx.doi.org/10.1021/ol0600234}}, doi = {{10.1021/ol0600234}}, volume = {{8}}, year = {{2006}}, }