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Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents

Ottesen, Lars K. ; Ek, Fredrik LU and Olsson, Roger LU (2006) In Organic Letters 8(9). p.1771-1773
Abstract

A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO2Me) gave excellent yields (89%).

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author
; and
publishing date
type
Contribution to journal
publication status
published
in
Organic Letters
volume
8
issue
9
pages
3 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:16623547
  • scopus:33646450274
ISSN
1523-7060
DOI
10.1021/ol0600234
language
English
LU publication?
no
id
d88b0bfa-c504-4d50-99f0-17ab40e82843
date added to LUP
2019-10-02 09:58:28
date last changed
2020-01-22 07:47:11
@article{d88b0bfa-c504-4d50-99f0-17ab40e82843,
  abstract     = {<p>A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO<sub>2</sub>Me) gave excellent yields (89%).</p>},
  author       = {Ottesen, Lars K. and Ek, Fredrik and Olsson, Roger},
  issn         = {1523-7060},
  language     = {eng},
  month        = {04},
  number       = {9},
  pages        = {1771--1773},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Organic Letters},
  title        = {Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents},
  url          = {http://dx.doi.org/10.1021/ol0600234},
  doi          = {10.1021/ol0600234},
  volume       = {8},
  year         = {2006},
}