Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape
(2017) In Immunity 46(4). p.532-548- Abstract
The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease... (More)
The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.
(Less)
- author
- Agace, William W. LU and McCoy, Kathy D
- organization
- publishing date
- 2017-04-18
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunity
- volume
- 46
- issue
- 4
- pages
- 17 pages
- publisher
- Cell Press
- external identifiers
-
- pmid:28423335
- wos:000399451100008
- scopus:85019047809
- ISSN
- 1074-7613
- DOI
- 10.1016/j.immuni.2017.04.004
- language
- English
- LU publication?
- yes
- id
- d899543a-3927-455b-af41-f7d58f7807f6
- date added to LUP
- 2017-06-08 08:48:55
- date last changed
- 2024-09-17 02:10:36
@article{d899543a-3927-455b-af41-f7d58f7807f6,
abstract = {{<p>The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.</p>}},
author = {{Agace, William W. and McCoy, Kathy D}},
issn = {{1074-7613}},
language = {{eng}},
month = {{04}},
number = {{4}},
pages = {{532--548}},
publisher = {{Cell Press}},
series = {{Immunity}},
title = {{Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape}},
url = {{http://dx.doi.org/10.1016/j.immuni.2017.04.004}},
doi = {{10.1016/j.immuni.2017.04.004}},
volume = {{46}},
year = {{2017}},
}