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Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

Agace, William W. LU and McCoy, Kathy D (2017) In Immunity 46(4). p.532-548
Abstract

The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease... (More)

The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunity
volume
46
issue
4
pages
17 pages
publisher
Cell Press
external identifiers
  • scopus:85019047809
  • wos:000399451100008
ISSN
1074-7613
DOI
10.1016/j.immuni.2017.04.004
language
English
LU publication?
yes
id
d899543a-3927-455b-af41-f7d58f7807f6
date added to LUP
2017-06-08 08:48:55
date last changed
2017-09-18 11:39:17
@article{d899543a-3927-455b-af41-f7d58f7807f6,
  abstract     = {<p>The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.</p>},
  author       = {Agace, William W. and McCoy, Kathy D},
  issn         = {1074-7613},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {532--548},
  publisher    = {Cell Press},
  series       = {Immunity},
  title        = {Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape},
  url          = {http://dx.doi.org/10.1016/j.immuni.2017.04.004},
  volume       = {46},
  year         = {2017},
}