Early vascular ageing in translation: from laboratory investigations to clinical applications in cardiovascular prevention.
(2013) In Journal of Hypertension 31(8). p.1517-1526- Abstract
- The ageing of the vascular tree is a fundamental reflection of biological ageing in general and a determinant of organ function. In the arterial wall this is characterized by a reduction in the elastin content, as well as by an increased content of collagen and its cross-linkages, leading to increased arterial stiffness and elevated central as well as brachial blood pressure, accompanied by increased SBP variability. In recent years a better understanding of these processes have led to the proposal of a condition named early vascular ageing (EVA) in patients with increased arterial stiffness for their age and sex. This is a condition that could increase cardiovascular risk and is associated with various degrees of cognitive dysfunction, as... (More)
- The ageing of the vascular tree is a fundamental reflection of biological ageing in general and a determinant of organ function. In the arterial wall this is characterized by a reduction in the elastin content, as well as by an increased content of collagen and its cross-linkages, leading to increased arterial stiffness and elevated central as well as brachial blood pressure, accompanied by increased SBP variability. In recent years a better understanding of these processes have led to the proposal of a condition named early vascular ageing (EVA) in patients with increased arterial stiffness for their age and sex. This is a condition that could increase cardiovascular risk and is associated with various degrees of cognitive dysfunction, as well as other features of biological ageing. This brief review aims to give an update on EVA and how the concept can be used in clinical practice. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3913632
- author
- Nilsson, Peter LU ; Boutouyrie, Pierre ; Cunha, Pedro ; Kotsis, Vasilios ; Narkiewicz, Krzysztof ; Parati, Gianfranco ; Rietzschel, Ernst ; Scuteri, Angelo and Laurent, Stephane
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Hypertension
- volume
- 31
- issue
- 8
- pages
- 1517 - 1526
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000326598600003
- pmid:23743805
- scopus:84893457418
- pmid:23743805
- ISSN
- 1473-5598
- DOI
- 10.1097/HJH.0b013e328361e4bd
- language
- English
- LU publication?
- yes
- id
- d8d89672-703b-4eff-aef4-288ac78d7fca (old id 3913632)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23743805?dopt=Abstract
- date added to LUP
- 2016-04-01 11:08:57
- date last changed
- 2022-04-28 07:43:58
@article{d8d89672-703b-4eff-aef4-288ac78d7fca,
abstract = {{The ageing of the vascular tree is a fundamental reflection of biological ageing in general and a determinant of organ function. In the arterial wall this is characterized by a reduction in the elastin content, as well as by an increased content of collagen and its cross-linkages, leading to increased arterial stiffness and elevated central as well as brachial blood pressure, accompanied by increased SBP variability. In recent years a better understanding of these processes have led to the proposal of a condition named early vascular ageing (EVA) in patients with increased arterial stiffness for their age and sex. This is a condition that could increase cardiovascular risk and is associated with various degrees of cognitive dysfunction, as well as other features of biological ageing. This brief review aims to give an update on EVA and how the concept can be used in clinical practice.}},
author = {{Nilsson, Peter and Boutouyrie, Pierre and Cunha, Pedro and Kotsis, Vasilios and Narkiewicz, Krzysztof and Parati, Gianfranco and Rietzschel, Ernst and Scuteri, Angelo and Laurent, Stephane}},
issn = {{1473-5598}},
language = {{eng}},
number = {{8}},
pages = {{1517--1526}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Early vascular ageing in translation: from laboratory investigations to clinical applications in cardiovascular prevention.}},
url = {{http://dx.doi.org/10.1097/HJH.0b013e328361e4bd}},
doi = {{10.1097/HJH.0b013e328361e4bd}},
volume = {{31}},
year = {{2013}},
}