Peripheral effects of PTH are not altered after thyroid surgery in euthyroid patients
(2001) In Hormone Research 56(3-4). p.105-109- Abstract
- Background. We have previously found decreased serum levels of both ionized calcium and 1,25(OH)(2)D and an increase in serum phosphate levels at 1 year after hemithyroidectomy. However, basal and stimulated parathyroid hormone (PTH) secretions were not altered. To investigate whether the observed biochemical changes after unilateral thyroid surgery may be due to a relative end-organ resistance to PTH, we studied the peripheral effects of infused hPTH-(1-34) in 6 patients preoperatively and 3 months after hemithyroidectomy. Methods: Serum levels of TSH, FT4 and FT3 were measured pre- and postoperatively. hPTH-(1-34) was infused at 0.9 IU/kg/h during 6 h. Blood samples for analysis of ionized calcium, intact PTH, phosphate, 25(OH)D,... (More)
- Background. We have previously found decreased serum levels of both ionized calcium and 1,25(OH)(2)D and an increase in serum phosphate levels at 1 year after hemithyroidectomy. However, basal and stimulated parathyroid hormone (PTH) secretions were not altered. To investigate whether the observed biochemical changes after unilateral thyroid surgery may be due to a relative end-organ resistance to PTH, we studied the peripheral effects of infused hPTH-(1-34) in 6 patients preoperatively and 3 months after hemithyroidectomy. Methods: Serum levels of TSH, FT4 and FT3 were measured pre- and postoperatively. hPTH-(1-34) was infused at 0.9 IU/kg/h during 6 h. Blood samples for analysis of ionized calcium, intact PTH, phosphate, 25(OH)D, 1,25(OH)(2)D and urinary samples for calcium, phosphate and nephrogenous(n)-cAMP analysis were taken at baseline, when the infusion was discontinued after 6 h and at 24 h. Results: Three months after hemithyroidectomy, serum levels of FT3 were decreased and TSH levels increased. Pre- and postoperative hPTH-(1-34) infusions induced increased serum levels of ionized calcium, 1,25(OH)2D, increased urinary excretion of phosphate and elevated n-cAMP levels. The changes in the studied biochemical variables during the hPTH-(1-34) infusions did not differ between the two study occasions. Conclusion: By using a 6-hour hPTH-(1-34) infusion protocol, we have shown that the peripheral PTH effect is not altered by a slight reduction in thyroid hormone levels at 3 months after hemithyroidectomy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1118470
- author
- Lindblom, Pia LU ; Isaksson, Anders LU ; Westerdahl, Johan LU and Bergenfelz, Anders LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hemithyroidectomy, hPTH-(1-34) infusion, PTH, peripheral, effects, Solitary cold thyroid nodules, Thyroid surgery
- in
- Hormone Research
- volume
- 56
- issue
- 3-4
- pages
- 105 - 109
- publisher
- Karger
- external identifiers
-
- wos:000174181600006
- scopus:0035722527
- ISSN
- 0301-0163
- DOI
- 10.1159/000048100
- language
- English
- LU publication?
- yes
- id
- d8e13c31-b753-4fee-9e0d-a7e3b7da41b7 (old id 1118470)
- date added to LUP
- 2016-04-01 16:45:54
- date last changed
- 2022-01-28 22:01:17
@article{d8e13c31-b753-4fee-9e0d-a7e3b7da41b7,
abstract = {{Background. We have previously found decreased serum levels of both ionized calcium and 1,25(OH)(2)D and an increase in serum phosphate levels at 1 year after hemithyroidectomy. However, basal and stimulated parathyroid hormone (PTH) secretions were not altered. To investigate whether the observed biochemical changes after unilateral thyroid surgery may be due to a relative end-organ resistance to PTH, we studied the peripheral effects of infused hPTH-(1-34) in 6 patients preoperatively and 3 months after hemithyroidectomy. Methods: Serum levels of TSH, FT4 and FT3 were measured pre- and postoperatively. hPTH-(1-34) was infused at 0.9 IU/kg/h during 6 h. Blood samples for analysis of ionized calcium, intact PTH, phosphate, 25(OH)D, 1,25(OH)(2)D and urinary samples for calcium, phosphate and nephrogenous(n)-cAMP analysis were taken at baseline, when the infusion was discontinued after 6 h and at 24 h. Results: Three months after hemithyroidectomy, serum levels of FT3 were decreased and TSH levels increased. Pre- and postoperative hPTH-(1-34) infusions induced increased serum levels of ionized calcium, 1,25(OH)2D, increased urinary excretion of phosphate and elevated n-cAMP levels. The changes in the studied biochemical variables during the hPTH-(1-34) infusions did not differ between the two study occasions. Conclusion: By using a 6-hour hPTH-(1-34) infusion protocol, we have shown that the peripheral PTH effect is not altered by a slight reduction in thyroid hormone levels at 3 months after hemithyroidectomy.}},
author = {{Lindblom, Pia and Isaksson, Anders and Westerdahl, Johan and Bergenfelz, Anders}},
issn = {{0301-0163}},
keywords = {{Hemithyroidectomy; hPTH-(1-34) infusion; PTH; peripheral; effects; Solitary cold thyroid nodules; Thyroid surgery}},
language = {{eng}},
number = {{3-4}},
pages = {{105--109}},
publisher = {{Karger}},
series = {{Hormone Research}},
title = {{Peripheral effects of PTH are not altered after thyroid surgery in euthyroid patients}},
url = {{http://dx.doi.org/10.1159/000048100}},
doi = {{10.1159/000048100}},
volume = {{56}},
year = {{2001}},
}