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Peripheral effects of PTH are not altered after thyroid surgery in euthyroid patients

Lindblom, Pia LU ; Isaksson, Anders LU ; Westerdahl, Johan LU and Bergenfelz, Anders LU (2001) In Hormone Research 56(3-4). p.105-109
Abstract
Background. We have previously found decreased serum levels of both ionized calcium and 1,25(OH)(2)D and an increase in serum phosphate levels at 1 year after hemithyroidectomy. However, basal and stimulated parathyroid hormone (PTH) secretions were not altered. To investigate whether the observed biochemical changes after unilateral thyroid surgery may be due to a relative end-organ resistance to PTH, we studied the peripheral effects of infused hPTH-(1-34) in 6 patients preoperatively and 3 months after hemithyroidectomy. Methods: Serum levels of TSH, FT4 and FT3 were measured pre- and postoperatively. hPTH-(1-34) was infused at 0.9 IU/kg/h during 6 h. Blood samples for analysis of ionized calcium, intact PTH, phosphate, 25(OH)D,... (More)
Background. We have previously found decreased serum levels of both ionized calcium and 1,25(OH)(2)D and an increase in serum phosphate levels at 1 year after hemithyroidectomy. However, basal and stimulated parathyroid hormone (PTH) secretions were not altered. To investigate whether the observed biochemical changes after unilateral thyroid surgery may be due to a relative end-organ resistance to PTH, we studied the peripheral effects of infused hPTH-(1-34) in 6 patients preoperatively and 3 months after hemithyroidectomy. Methods: Serum levels of TSH, FT4 and FT3 were measured pre- and postoperatively. hPTH-(1-34) was infused at 0.9 IU/kg/h during 6 h. Blood samples for analysis of ionized calcium, intact PTH, phosphate, 25(OH)D, 1,25(OH)(2)D and urinary samples for calcium, phosphate and nephrogenous(n)-cAMP analysis were taken at baseline, when the infusion was discontinued after 6 h and at 24 h. Results: Three months after hemithyroidectomy, serum levels of FT3 were decreased and TSH levels increased. Pre- and postoperative hPTH-(1-34) infusions induced increased serum levels of ionized calcium, 1,25(OH)2D, increased urinary excretion of phosphate and elevated n-cAMP levels. The changes in the studied biochemical variables during the hPTH-(1-34) infusions did not differ between the two study occasions. Conclusion: By using a 6-hour hPTH-(1-34) infusion protocol, we have shown that the peripheral PTH effect is not altered by a slight reduction in thyroid hormone levels at 3 months after hemithyroidectomy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hemithyroidectomy, hPTH-(1-34) infusion, PTH, peripheral, effects, Solitary cold thyroid nodules, Thyroid surgery
in
Hormone Research
volume
56
issue
3-4
pages
105 - 109
publisher
Karger
external identifiers
  • wos:000174181600006
  • scopus:0035722527
ISSN
0301-0163
DOI
10.1159/000048100
language
English
LU publication?
yes
id
d8e13c31-b753-4fee-9e0d-a7e3b7da41b7 (old id 1118470)
date added to LUP
2008-07-03 12:53:11
date last changed
2018-01-07 09:31:22
@article{d8e13c31-b753-4fee-9e0d-a7e3b7da41b7,
  abstract     = {Background. We have previously found decreased serum levels of both ionized calcium and 1,25(OH)(2)D and an increase in serum phosphate levels at 1 year after hemithyroidectomy. However, basal and stimulated parathyroid hormone (PTH) secretions were not altered. To investigate whether the observed biochemical changes after unilateral thyroid surgery may be due to a relative end-organ resistance to PTH, we studied the peripheral effects of infused hPTH-(1-34) in 6 patients preoperatively and 3 months after hemithyroidectomy. Methods: Serum levels of TSH, FT4 and FT3 were measured pre- and postoperatively. hPTH-(1-34) was infused at 0.9 IU/kg/h during 6 h. Blood samples for analysis of ionized calcium, intact PTH, phosphate, 25(OH)D, 1,25(OH)(2)D and urinary samples for calcium, phosphate and nephrogenous(n)-cAMP analysis were taken at baseline, when the infusion was discontinued after 6 h and at 24 h. Results: Three months after hemithyroidectomy, serum levels of FT3 were decreased and TSH levels increased. Pre- and postoperative hPTH-(1-34) infusions induced increased serum levels of ionized calcium, 1,25(OH)2D, increased urinary excretion of phosphate and elevated n-cAMP levels. The changes in the studied biochemical variables during the hPTH-(1-34) infusions did not differ between the two study occasions. Conclusion: By using a 6-hour hPTH-(1-34) infusion protocol, we have shown that the peripheral PTH effect is not altered by a slight reduction in thyroid hormone levels at 3 months after hemithyroidectomy.},
  author       = {Lindblom, Pia and Isaksson, Anders and Westerdahl, Johan and Bergenfelz, Anders},
  issn         = {0301-0163},
  keyword      = {Hemithyroidectomy,hPTH-(1-34) infusion,PTH,peripheral,effects,Solitary cold thyroid nodules,Thyroid surgery},
  language     = {eng},
  number       = {3-4},
  pages        = {105--109},
  publisher    = {Karger},
  series       = {Hormone Research},
  title        = {Peripheral effects of PTH are not altered after thyroid surgery in euthyroid patients},
  url          = {http://dx.doi.org/10.1159/000048100},
  volume       = {56},
  year         = {2001},
}