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An online atlas of human plasma metabolite signatures of gut microbiome composition

Dekkers, Koen F. ; Sayols-Baixeras, Sergi ; Baldanzi, Gabriel ; Nowak, Christoph ; Hammar, Ulf ; Nguyen, Diem ; Varotsis, Georgios ; Brunkwall, Louise LU ; Nielsen, Nynne and Eklund, Aron C. , et al. (2022) In Nature Communications 13(1).
Abstract

Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58%... (More)

Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas (https://gutsyatlas.serve.scilifelab.se/). We exemplify the potential of this resource by presenting novel associations between dietary factors and oral medication with the gut microbiome, and microbial species strongly associated with the uremic toxin p-cresol sulfate. This resource can be used as the basis for targeted studies of perturbation of specific metabolites and for identification of candidate plasma biomarkers of gut microbiota composition.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
13
issue
1
article number
5370
publisher
Nature Publishing Group
external identifiers
  • pmid:36151114
  • scopus:85138457667
ISSN
2041-1723
DOI
10.1038/s41467-022-33050-0
language
English
LU publication?
yes
id
d8e42fb0-02a3-4b26-aec7-0753bc48d677
date added to LUP
2023-01-13 13:03:04
date last changed
2024-06-29 03:08:37
@article{d8e42fb0-02a3-4b26-aec7-0753bc48d677,
  abstract     = {{<p>Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas (https://gutsyatlas.serve.scilifelab.se/). We exemplify the potential of this resource by presenting novel associations between dietary factors and oral medication with the gut microbiome, and microbial species strongly associated with the uremic toxin p-cresol sulfate. This resource can be used as the basis for targeted studies of perturbation of specific metabolites and for identification of candidate plasma biomarkers of gut microbiota composition.</p>}},
  author       = {{Dekkers, Koen F. and Sayols-Baixeras, Sergi and Baldanzi, Gabriel and Nowak, Christoph and Hammar, Ulf and Nguyen, Diem and Varotsis, Georgios and Brunkwall, Louise and Nielsen, Nynne and Eklund, Aron C. and Bak Holm, Jacob and Nielsen, H. Bjørn and Ottosson, Filip and Lin, Yi Ting and Ahmad, Shafqat and Lind, Lars and Sundström, Johan and Engström, Gunnar and Smith, J. Gustav and Ärnlöv, Johan and Orho-Melander, Marju and Fall, Tove}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{An online atlas of human plasma metabolite signatures of gut microbiome composition}},
  url          = {{http://dx.doi.org/10.1038/s41467-022-33050-0}},
  doi          = {{10.1038/s41467-022-33050-0}},
  volume       = {{13}},
  year         = {{2022}},
}