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Plasma protein homeostasis in chronic hemodialysis patients

Lindgren, Stefan LU ; Laurell, Carl Bertil and Sterner, Gunnar LU (1992) In Scandinavian journal of urology and nephrology 26(3). p.279-282
Abstract
The concentrations of 25 plasma proteins were measured in 29 patients with chronic renal insufficiency. All the patients had terminal renal failure and were treated with intermittent hemodialysis, but were otherwise in good general condition at the time of investigation. The plasma levels of 8 proteins with Mr<50 kD were significantly elevated compared to normal subjects. In contrast, only 2/17 proteins of greater size were found in increased concentrations. The degree of increase in concentration differed substantially between individual low molecular weight proteins, suggesting a complex metabolism in addition to delayed renal elimination. Acute phase proteins and immunoglobulins were not affected by renal insufficiency per se,... (More)
The concentrations of 25 plasma proteins were measured in 29 patients with chronic renal insufficiency. All the patients had terminal renal failure and were treated with intermittent hemodialysis, but were otherwise in good general condition at the time of investigation. The plasma levels of 8 proteins with Mr<50 kD were significantly elevated compared to normal subjects. In contrast, only 2/17 proteins of greater size were found in increased concentrations. The degree of increase in concentration differed substantially between individual low molecular weight proteins, suggesting a complex metabolism in addition to delayed renal elimination. Acute phase proteins and immunoglobulins were not affected by renal insufficiency per se, although erythrocyte sedimentation rates were generally high. The synthesis of acute phase proteins increased normally during the course of inflammation. We conclude that although the sedimentation rate is of no value, complicating inflammatory processes can be traced by quantitative analysis of acute phase proteins, including C-reactive protein, even in patients with severe chronic renal insufficiency. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian journal of urology and nephrology
volume
26
issue
3
pages
279 - 282
publisher
Taylor & Francis
ISSN
2168-1813
DOI
10.3109/00365599209180883
language
English
LU publication?
yes
id
d8f258a7-565f-4118-ae6b-8183b3f795ca
date added to LUP
2019-10-26 22:37:43
date last changed
2019-11-11 15:45:12
@article{d8f258a7-565f-4118-ae6b-8183b3f795ca,
  abstract     = {The concentrations of 25 plasma proteins were measured in 29 patients with chronic renal insufficiency. All the patients had terminal renal failure and were treated with intermittent hemodialysis, but were otherwise in good general condition at the time of investigation. The plasma levels of 8 proteins with Mr&lt;50 kD were significantly elevated compared to normal subjects. In contrast, only 2/17 proteins of greater size were found in increased concentrations. The degree of increase in concentration differed substantially between individual low molecular weight proteins, suggesting a complex metabolism in addition to delayed renal elimination. Acute phase proteins and immunoglobulins were not affected by renal insufficiency per se, although erythrocyte sedimentation rates were generally high. The synthesis of acute phase proteins increased normally during the course of inflammation. We conclude that although the sedimentation rate is of no value, complicating inflammatory processes can be traced by quantitative analysis of acute phase proteins, including C-reactive protein, even in patients with severe chronic renal insufficiency.},
  author       = {Lindgren, Stefan and Laurell, Carl Bertil and Sterner, Gunnar},
  issn         = {2168-1813},
  language     = {eng},
  number       = {3},
  pages        = {279--282},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian journal of urology and nephrology},
  title        = {Plasma protein homeostasis in chronic hemodialysis patients},
  url          = {http://dx.doi.org/10.3109/00365599209180883},
  doi          = {10.3109/00365599209180883},
  volume       = {26},
  year         = {1992},
}